The effect of thioctic acid on the activity of the antioxidant glutathione-dependent system under conditions of toxic hepatitis in rats
A. V. Makeeva1, T. N. Popova1 and L. V. Matasova1
School of Biology and Soil Science, Voronezh State University, Universitetskaya square, 1, Voronezh, 394693, Russia
Received: 26 December 2005
Abstract The effect of thioctic acid on functioning of the antioxidant glutathione-dependent system and activity of enzymes, supplying this system with NADPH, were studied under conditions of toxic hepatitis in rats. A decrease in the glutathione reductase and glutathione peroxidase activities towards normal levels was observed in animals with toxic hepatitis after administration of thioctic acid. Administration of thioctic acid under conditions of toxic hepatitis caused a decrease in the NADPH-dependent isocitrate dehydrogenase and glucose-6-phosphate dehydrogenase activities; this evidently reflects lowered requirements in the NADPH supply for operation of the glutathione-dependent system. Thus, these studies have shown that thioctic acid may serve as a factor regulating the extent of the oxidative stress development and the state of the glutathione antioxidant system.
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