Beets for Alzheimer (try and remember that!)

Beets for Alzheimer  (try and remember that!)

Dr. Weeks’ Comment:   last week I reread  Tom Robbin’s  fabulous novel   “Jitterbug Perfume” which features beets.  Here is an article demonstrating a cognitive benefit from eating beets.

I like my beets in the ecstatic culinary fete which is  Laura’s borscht!  but beet juice (organic is best) alone suffices.

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Acute effect of a high nitrate diet on brain perfusion in older adultsE-mail The Corresponding Author and Gary D. Millerb, g, Corresponding Author Contact Information, 1, E-mail The Corresponding Author

a Department of Physics, Wake Forest University, Winston-Salem, NC 27109, USA

Received 20 July 2010;
revised 7 October 2010.
Available online 15 October 2010.

Abstract

Aims

Poor blood flow and hypoxia/ischemia contribute to many disease states and may also be a factor in the decline of physical and cognitive function in aging. Nitrite has been discovered to be a vasodilator that is preferentially harnessed in hypoxia. Thus, both infused and inhaled nitrite are being studied as therapeutic agents for a variety of diseases. In addition, nitrite derived from nitrate in the diet has been shown to decrease blood pressure and improve exercise performance. Thus, dietary nitrate may also be important when increased blood flow in hypoxic or ischemic areas is indicated. These conditions could include age-associated dementia and cognitive decline. The goal of this study was to determine if dietary nitrate would increase cerebral blood flow in older adults.

Methods and results

In this investigation we administered a high vs. low nitrate diet to older adults (74.7 ± 6.9 years) and measured cerebral perfusion using arterial spin labeling magnetic resonance imaging. We found that the high nitrate diet did not alter global cerebral perfusion, but did lead to increased regional cerebral perfusion in frontal lobe white matter, especially between the dorsolateral prefrontal cortex and anterior cingulate cortex.

Conclusion

These results suggest that dietary nitrate may be useful in improving regional brain perfusion in older adults in critical brain areas known to be involved in executive functioning.

From Science Daily:

Researchers for the first time have shown that drinking beet juice can increase blood flow to the brain in older adults — a finding that could hold great potential for combating the progression of dementia.The research findings are available online in Nitric Oxide: Biology and Chemistry, the peer-reviewed journal of the Nitric Oxide Society and will be available in print soon.

“There have been several very high-profile studies showing that drinking beet juice can lower blood pressure, but we wanted to show that drinking beet juice also increases perfusion, or blood flow, to the brain,” said Daniel Kim-Shapiro, director of Wake Forest University’s Translational Science Center; Fostering Independence in Aging. “There are areas in the brain that become poorly perfused as you age, and that’s believed to be associated with dementia and poor cognition.”

High concentrations of nitrates are found in beets, as well as in celery, cabbage and other leafy green vegetables like spinach and some lettuce. When you eat high-nitrate foods, good bacteria in the mouth turn nitrate into nitrite. Research has found that nitrites can help open up the blood vessels in the body, increasing blood flow and oxygen specifically to places that are lacking oxygen.

In this study, the first to find a link between consumption of nitrate-rich beet juice and increased blood flow to the brain, Translational Science Center researchers looked at how dietary nitrates affected 14 adults age 70 and older over a period of four days.

On the first day, the study subjects reported to the lab after a 10-hour fast, completed a health status report, and consumed either a high- or low-nitrate breakfast. The high-nitrate breakfast included 16 ounces of beet juice. They were sent home with lunch, dinner and snacks conforming to their assigned diets.

The next day, following another 10-hour fast, the subjects returned to the lab, where they ate their assigned breakfasts. One hour after breakfast, an MRI recorded the blood flow in each subject’s brain. Blood tests before and after breakfast confirmed nitrite levels in the body.

For the third and fourth days of the study, the researchers switched the diets and repeated the process for each subject.

The MRIs showed that after eating a high-nitrate diet, the older adults had increased blood flow to the white matter of the frontal lobes — the areas of the brain commonly associated with degeneration that leads to dementia and other cognitive conditions.

“I think these results are consistent and encouraging — that good diet consisting of a lot of fruits and vegetables can contribute to overall good health,” said Gary Miller, associate professor in the Department of Health and Exercise Science and one of the senior investigators on the project.

To make the sometimes-bitter beet juice tastier — so a greater number of people will drink it and reap its health benefits — the university has worked with a company to create a new beet juice-based beverage. The university is currently looking into ways of marketing the beverage.

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