Fungal compound galiellalactone may combat prostate cancer STEM cells

Dr. Weeks’ Comment:  Here we have a natural product, galiellalactone  (from fungus)  which interrupts the dangerous IL-6  (this is the  “SOS”  signal which Professor Max Wicha  (oncologist) claims increases cancer recruitment)  and thereby accomplishes the goal to stopping cancer STEM cells.    Haelan  951,  the fermented whole organic soy does this also…  I wonder which tastes better!

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Treating Resistant Prostate Cancer By Attacking Stem Cell-Like Cells

Scientists from Sweden are working on a treatment which attacks stem cell-like cells in prostate cancer. The technology could be useful for prostate cancer patients who do not respond to chemotherapy or radiation therapy, the scientists informed in the journal PLoS ONE.

The researchers, from Lund University and Skåne University Hospital in Malmö, both in Sweden, have been developing a therapy that works by targeting a protein in prostate cancer stem cells. The STAT3 protein is vital for the growth and regeneration of the stem cells.

Galiellalactone, a natural compound, inhibits the activity of STAT3, i.e. it undermines the growth of prostate cancer.

The discovery, which is still in its early stages, is a number of years away from entering clinical practice, the authors stress. However, they believe their findings will help in the creation of new medications which could improve prostate cancer treatment considerably.

By using galiellalactone, the authors say that new specific STAT3-inhibitors may be developed which attack the stem cell-like cancer cells in prostate cancer, effectively preventing the tumor from growing and spreading.

Professor Anders Bjartell, from the Faculty of Medicine’s division for Urological Cancer Research, SkÃ¥ne University Hospital in Malmö, said:
“Prostatic tumours are thought to consist only of about 0.1 per cent cancer stem cells, but if you are not successful in eradicating that tumour cell population, there is a risk of subsequent uncontrolled growth of the tumour. The cancer stem cells are often unresponsive to both hormonal treatment and to chemotherapy, so it is essential to develop a direct treatment towards all types of cancer cells.”
The authors concluded:

“These findings emphasize that targeting the STAT3 pathway in prostate cancer cells, including prostate cancer stem cell-like cells, is a promising therapeutic approach and that galiellalactone is an interesting compound for the development of future prostate cancer drugs.”

 

 

aliellalactone is a novel therapeutic candidate against hormone …

Prostate. 2008 Feb 15;68(3):269-80. Galiellalactone is a novel therapeutic candidate against hormone-refractory prostate cancer expressing activated Stat3.

http://www.ncbi.nlm.nih.gov/pubmed/18163422

Inhibition of interleukin-6 signaling by galiellalactone.

FEBS Lett. 2000 Oct 27;484(1):1-6. Inhibition of interleukin-6 signaling by

http://www.ncbi.nlm.nih.gov/pubmed/11056211

Galiellalactone CAS (133613-71-5) sc-202165

Buy Galiellalactone (CAS 133613-71-5), inhibits IL-6 induced SEAP expression, from Santa Cruz. Purity: >95%, Molecular Formula: C11H14O3 MW: 194.2.

http://www.scbt.com/datasheet-202165-galiellalactone.html

Synthesis of (+)-Galiellalactone. Absolute Configuration of …

4 Aug 2001 (+)-Galiellalactone was synthesized starting from (R)-(+)-pulegone. Natural and synthetic galiellalactone have opposite optical rotations,

http://pubs.acs.org/doi/abs/10.1021/ol016286%2B

PLoS ONE: Galiellalactone Inhibits Stem Cell-Like ALDH-Positive …

Galiellalactone is a potent and specific inhibitor of STAT3 signaling which has been shown to possess growth inhibitory effects on prostate cancer cells

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0022118

Galiellalactone and the inhibition of prostate cancer stem cells …

5 days ago A new paper just published in PLoS ONE describes a development-stage drug known as galiellalactone and how it acts to inhibit the growth of

http://prostatecancerinfolink.net/2011/08/12/galiellalactone-and-the-inhibition-of-prostate-cancer-stem-cells/

Fungal compound galiellalactone may combat prostate cancer

3 Apr 2007 Can a substance from a fungus that grows on decaying trees provide a cure for aggressive prostate cancer? This is the hope of researchers at

http://www.news-medical.net/news/2007/04/03/22998.aspx

Biosynthetic and synthetic studies of the fungal metabolite …

4 Jun 2005 Abstract: Galiellalactone is a fungal metabolite found in the basidiomycetes Galiella rufa and the unidentified strain A111-95.

http://www.organic.lu.se/Publications/Ph.%20D.%20theses/M_Johansson.html

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Dr. Weeks’ Comment:  Here we have a natural product, galiellalactone  (from fungus)  which interrupts the dangerous IL-6  (this is the  “SOS”  signal which Professor Max Wicha  (oncologist) claims increases cancer recruitment)  and thereby accomplishes the goal to stopping cancer STEM cells.    Haelan  951,  the fermented whole organic soy does this also…  I wonder which tastes…
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