google antalya escort
0

Curcumin for Cancer – the research grows stronger.

Dr. Weeks’ Comment:  Curcumin (tumeric) remains a potent anti-inflammatory agent with a strong track record for cancer.  Here is the latest:

“Extensive studies documented that curcumin attenuates cancer cell proliferation and promotes apoptosis in vivo and in vitro.”

“Curcumin as a natural phytochemicals could communicate with these novel targets and show synergism to chemotherapy.”


 

Curcumin: Updated Molecular Mechanisms and Intervention Targets in Human Lung Cancer

Int. J. Mol. Sci. 201213(3), 3959-3978; doi:10.3390/ijms13033959

Ming-Xiang Ye 1,† , Yan Li 2,† , Hong Yin 3,*  and Jian Zhang 1,*

 

1 Department of Pulmonary Medicine, Detection Center of Tumor Biomarker, Xijing Hospital, Fourth Military Medical University, 710032 Xi’an, China

2 Department of Pulmonary Medicine, First People’s Hospital of Xi’an, 710032 Xi’an, China

3 Department of Radiology, Medical Imaging Center, Xijing Hospital, Fourth Military Medical University, 710032 Xi’an, China

These authors contributed equally to this work.

Received: 6 February 2012; in revised form: 5 March 2012 / Accepted: 15 March 2012 / Published: 22 March 2012

 

 Download PDF Full-Text [385 KB, uploaded 22 March 2012 14:17 CET]

 

Abstract: Curcumin, a yellow pigment derived from Curcuma longa Linn, has attracted great interest in the research of cancer during the past decades. Extensive studies documented that curcumin attenuates cancer cell proliferation and promotes apoptosis in vivo and in vitro. Curcumin has been demonstrated to interact with multiple molecules and signal pathways, which makes it a potential adjuvant anti-cancer agent to chemotherapy. Previous investigations focus on the mechanisms of action for curcumin, which is shown to manipulate transcription factors and induce apoptosis in various kinds of human cancer. Apart from transcription factors and apoptosis, emerging studies shed light on latent targets of curcumin against epidermal growth factor receptor (EGFR), microRNAs (miRNA), autophagy and cancer stem cell. The present review predominantly discusses significance of EGFR, miRNA, autophagy and cancer stem cell in lung cancer therapy. Curcumin as a natural phytochemicals could communicate with these novel targets and show synergism to chemotherapy. Additionally, curcumin is well tolerated in humans. Therefore, EGFR-, miRNA-, autophagy- and cancer stem cell-based therapy in the presence of curcumin might be promising mechanisms and targets in the therapeutic strategy of lung cancer.

 

MDPI and ACS Style

Ye, M.-X.; Li, Y.; Yin, H.; Zhang, J. Curcumin: Updated Molecular Mechanisms and Intervention Targets in Human Lung Cancer. Int. J. Mol. Sci. 2012, 13, 3959-3978.

AMA Style

Ye M.-X., Li Y., Yin H., Zhang J. Curcumin: Updated Molecular Mechanisms and Intervention Targets in Human Lung Cancer. International Journal of Molecular Sciences. 2012; 13(3):3959-3978.

Chicago/Turabian Style

Ye, Ming-Xiang; Li, Yan; Yin, Hong; Zhang, Jian. 2012. “Curcumin: Updated Molecular Mechanisms and Intervention Targets in Human Lung Cancer.” Int. J. Mol. Sci. 13, no. 3: 3959-3978.

Print Friendly
Filed in: Ask Your Doctor About, Cancer

Recent Posts

© 0442 WeeksMD. All rights reserved.

WELCOME!

The information contained on these web pages is derived from Dr. Weeks’ years of clinical experience and his review of scientific literature. However, these ideas and information are for your education and entertainment only. They are positively not intended to be a substitute for careful medical evaluation and treatment by a competent, licensed personal health care professional. Dr. Weeks and his associates do not recommend changing any current medications or adding any new therapies without personally consulting a fully qualified physician. Dr. Weeks and his staff specifically disclaim any liability arising directly or indirectly from information contained on these Web pages.

Varying and even conflicting views are held by other segments of the medical profession. The information presented on these Web pages is intended to be educational and entertaining in nature and is not intended as a basis for diagnosis or treatment. This information is current at the time of posting on the World Wide Web, and is published and distributed as a courtesy to the public.