Disulfram and Cancer – ask your oncologist to consider.

Dr. Weeks’ Comment:  In the perpetual effort to minimize side-effects from chemotherapy while enhancing its potency, we seek potentiating agents.  Insulin is one such potentiating agent remarkable in that it pushes cancer cells into their S phase (synthesis) where they are vulnerable to chemotherapy and also in that it makes the cancer cell membrane selectively more permeable to chemotherapy than are regular healthy cell membranes – hence targeted chemotherapy.  Now, we find other strategies to enhance the benefits while reducing the toxicities of chemo therapy:  fasting is cheap and effective.  And there are some medications, all cheap and off -patent which are rising stars:  the benefits of Metformin (Glucophage) are well known yet sadly, little used, by oncologists  and now Difulfram (Antabuse) a drug which is used to deter alcoholics from drinking is worth asking your oncologist to add to your protocol.   Here is a brief list of some promising research about Disulfram from peer-reveiwed literature. 

 

 

Disulfiram‐mediated inhibition of NF‐κB activity enhances cytotoxicity of 5‐fluorouracil in human colorectal cancer cell lines

W Wang, HL McLeod, J Cassidy – … journal of cancer, 2003 – Wiley Online Library
Wang, W., McLeod, HL and Cassidy, J.(2003), Disulfiram-mediated inhibition of NF-κB
activity enhances cytotoxicity of 5-fluorouracil in human colorectal cancer cell lines.
International Journal of Cancer, 104: 504–511. doi: 10.1002/ijc. 10972

Disulfiram, a clinically used anti-alcoholism drug and copper-binding agent, induces apoptotic cell death in breast cancer cultures and xenografts via inhibition of the …

D Chen, QC Cui, H Yang, QP Dou – Cancer research, 2006 – AACR
Abstract Disulfiram (DSF), a member of the dithiocarbamate family capable of binding
copper and an inhibitor of aldehyde dehydrogenase, is currently being used clinically for the
treatment of alcoholism. Recent studies have suggested that DSF may have antitumor and 

Investigations into the metabolism and mode of action of the colon carcinogens 1, 2‐dimethylhydrazine and azoxymethane

ES Fiala – Cancer, 1977 – Wiley Online Library
 Colon cancer can be induced reliably in rodents with 1,2-dimethylhydrazine and azoxymethane
(AOM).  A partial summary of our previous work on the metabolism of 1,2-dimethylhydrazine and
its inhibition by disulfiram, carbon disulfide and other thiono-sulfur compounds is 

Synergistic and antagonistic combinations of drugs in human prostate cancer cell lines in vitro

DR Budman, A Calabro, W Kreis – Anti-cancer drugs, 2002 – journals.lww.com
 In contrast, in the androgen-independent PC 3 and DU 145 lines, doxorubicin, epirubicin,
cyclosporin A, disulfiram and vinorelbine, but not vinblastine, demonstrated consistent synergy.
Figure 1 illustrates the entire drug interaction in DU 145 prostate cancer cells for the 

The value of proteasome inhibition in cancer: Can the old drug, disulfiram, have a bright new future as a novel proteasome inhibitor?

B Cvek, Z Dvorak – Drug discovery today, 2008 – Elsevier
The major approach to the development of anticancer drugs involves searching for new
compounds, efficient against malignancies, which are not, as yet, used clinically. This
strategy is time-consuming and expensive. Recent studies have disclosed a surprising, 

One Response to "Disulfram and Cancer – ask your oncologist to consider."

  1. Actually, disulfiram does not exist in the body after consumption. It is quickly metabolized to ditiocarb. And we have already phase II clinical trial of ditiocarb as ajduvant in breast cancer patients. Very hopefull (consider very low dosage in the trial: Dufour et al. Biotherapy 1993). More information: Cvek B. Current Cancer Drug Targets 2011. I will send pdf of both papers (Dufour and Cvek), please contact me: cvekb@seznam.cz

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