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    Do you or a loved one take SSRI drugs? Were you informed of the risks and benefits?

    Dr. Weeks’ Comment:  Informed consent is the foundation stone of a civilized relationship among consenting adults.  In medical practice, informed consent is the start of all treatment protocols without which no protocol should be offered.  The doctor is obligated to share, to the best of his or her ability, the pros and cons, benefits and risks of the proposed treatment as well as other competing treatments in order that the patient can be informed and freely choose the treatment which he or she prefers.   It is an art as well as a science to offer full information allowing a free consent because communication between patient and doctor is compromised on account of many stressors including time constraints, stress  (felt by both patient and doctor – for different reasons) careless use of incomprehensible medical jargon, i.e. Latin terms for illnesses “lateral epicondylitis” = pain on side of elbow so why not say it!).  But when you or your loved one was started on an  SSRI drug (probably by a family practitioner ?), did the Doc tell you that SSRI drugs can interfere with your ability to drive?  Read on!

    hypnotized driver

    Are selective serotonin reuptake inhibitors safe for drivers? What is the evidence?

     

    Clin Ther. 2012 May;34(5):1070-83. doi: 10.1016/j.clinthera.2012.04.002. Epub 2012 May 2.

     

    Ravera S, Ramaekers JG, de Jong-van den Berg LT, de Gier JJ.

    Abstract

    BACKGROUND:

    Selective serotonin reuptake inhibitors (SSRIs) are widely used medications to treat several psychiatric diseases and, above all, depression. They seem to be as effective as older antidepressants but have a different adverse effect profile. Despite their favorable safety profile, little is known about their influence on traffic safety.

    OBJECTIVE:

    To conduct a literature review to summarize the current evidence on the role of SSRIs in traffic safety, particularly concerning undesirable effects that could potentially impair fitness to drive, experimental and pharmacoepidemiologic studies on driving impairment, 2 existing categorization systems for driving-impairing medications, and the European legislative procedures for assessing fitness to drive before issuing a driver’s license and driving under the influence of medicines.

    METHODS:

    The article search was performed in the following electronic databases: MEDLINE, PsycINFO, ScienceDirect, and SafetyLit. The English-language scientific literature was searched using key words such as SSRIs and psychomotor performance, car crash or traffic accident, and adverse effects. For inclusion in this review, papers had to be full-text articles, refer to possible driving-related adverse effects, and be experimental or pharmacoepidemiologic studies on SSRIs and traffic accident risks. No restrictions concerning publication year were applied.

    RESULTS:

    Ten articles were selected as background information on driving-related adverse effects, and 15 articles were selected regarding experimental and pharmacoepidemiologic work. Regarding SSRI adverse effects, the most reported undesirable effects referring to driving impairment were anxiety, agitation, sleep disturbances, headache, increased risk of suicidal behavior, and deliberate self-harm. Regarding the remaining issues addressed in this article, inconsistencies were found between the outcomes of the selected experimental and epidemiologic studies and between the 2 existing categorization systems under evaluation. Some pitfalls of the current legislative scenario were identified as well.

    CONCLUSIONS:

    Based on the current evidence, it was concluded that more experimental and epidemiologic research is needed to elucidate the relationship between SSRI use and traffic safety. Furthermore, a revision of the existing categorization systems and harmonized European legislation in the field of medication use and driving were highly recommended.

     

    OK  so  here is the NEW research (published 4 years earlier!):

     

     

    Antidepressants May Impair Driving Ability, New Research Finds

     

    Presentation: “The Effects of Antidepressants on Cognitive and Driving Performance,” Holly J. Dannewitz, PhD, and Thomas Petros, PhD, University of North Dakota; Poster Session 4110,  Aug. 17, Boston Convention and Exhibition Center.

     

    Aug. 18, 2008 — People taking prescription antidepressants appear to drive worse than people who aren’t taking such drugs, and depressed people on antidepressants have even more trouble concentrating and reacting behind the wheel.

     

    These were the conclusions of a study recently released at the Annual Convention of the American Psychological Association. University of North Dakota psychologists Holly Dannewitz. PhD, and Tom Petros, PhD, recruited 60 people to participate in a driving simulation in which participants had to make a series of common driving decisions, such as reacting to brake lights, stop signs or traffic signals while being distracted by speed limit signs, pylons, animals, other cars, helicopters or bicyclists.

     

    The simulation tested steering, concentration and scanning. Thirty-one of the participants were taking at least one type of antidepressant while 29 control group members were taking no medications with the exception of oral contraceptives in some cases.

     

    The group taking antidepressants was further divided into those who scored higher and lower on a test of depression. The group taking antidepressants who reported a high number of symptoms of depression performed significantly worse than the control group on several of the driving performance tasks. But participants who were taking antidepressants and scored in the normal range on a test to measure depression performed no differently than the non-medicated individuals.

    “Individuals taking antidepressants should be aware of the possible cognitive effects as [they] may affect performance in social, academic and work settings, as well as driving abilities,” the researchers wrote. “However, it appears that mood is correlated with cognitive performance, more so than medication use.”

     

    This research is important in light of the rapid increase in the number of Americans taking antidepressants. Americans’ use of antidepressant drugs such as Prozac, Paxil or Zoloft, nearly tripled in a decade, according to the 2004 Health United States report, issued by the National Center for Health Statistics. Among women, one in 10 takes an antidepressant drug, according to the government.

     

     

    REGARDING MY PRACTICE:

    Since completing my residency in psychiatry at Dartmouth (Mary Hitchcock Medical Center), I have long been reluctant to prescribe SSRI (selective serotonin reuptake inhibitor) drugs to patients because of two reasons:  1) the side-effects typically exceed the benefits and 2) there are safer and effective and cheaper corrective options available. As a medical doctor, this is in accordance with the fundamental rule of the practice of medicine  “First Do No Harm”  (“Primum Non Nocere”).

     

    Also, my friend Ann Black Tracy PhD has compiled two highly informative websites which serve as a warning regarding the problems with this class of medication.

    I recommend that you and your loved ones carefully consider the content of her websites:

    1) www.drugawareness.org

    2) www.ssristories.com

     

     

    Also I received the following note from John Veneruso

    360-608-8363

     

    “On behalf of a friend who had been put on SSRI’s, I researched the question about whether they are effective and what harms they do.  I found numerous peer-reviewed scientific articles that I’ve organized simply below with links for easy reading.  Many of these sources are fairly recent as the field of Neuroscience has shed new light on the brain and independent research at universities and elsewhere begins to answer some of the major longer-term questions.  I’ll let the articles speak for themselves.” 

     

     

     

    Full Summary of Articles on SSRI’s that John Veneruso found so far, organized by topic.

     

     

    Hippocratic Oath:  First do no harm…

    http://en.wikipedia.org/wiki/Hippocratic_Oath

     

    Ethical issues in psychopharmacology: National Institutes of Health

    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2564489/

     

    SSRI’s no better than a Placebo

     

    Newsweek Article:  The Depressing news about Antidepressants

    http://www.thedailybeast.com/newsweek/2010/01/28/the-depressing-news-about-antidepressants.html

     

    Post-Prozac Nation: NY Times article

    http://www.nytimes.com/2012/04/22/magazine/the-science-and-history-of-treating-depression.html?pagewanted=all&_r=0&pagewanted=print

     

    SEROTONIN AND DEPRESSION: A DISCONNECT BETWEEN THE ADVERTISEMENTS AND THE SCIENTIFIC LITERATURE: PLOS MEDICINE JOURNAL

    http://www.plosmedicine.org/article/info%3Adoi%2F10.1371%2Fjournal.pmed.0020392

     

    Antidepressant Drug Effects and Depression Severity:  A Patient-Level Meta-analysis

    http://jama.jamanetwork.com/article.aspx?articleid=185157

     

    Uncovering a Flaw in Drug Testing for Chronic Anxiety Disorder

    http://www.sciencedaily.com/releases/2012/12/121213132557.htm

     

    Relapse During SSRI Treatment for Depression

    http://www.medscape.com/viewarticle/431524_4

     

    Suicidal Behavior:  Black Box Warning

    Note:  Increase risk in suicidal behavior seen to increase by 2 to 5 times normal level regardless of reason for prescribing an SSRI.

     

    With all the recent concern about SSRIs and suicidality, what advice should be given to the practising clinician regarding the management of a depressed young person?

    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC518869/

     

    Drop in SSRI Prescribing in the United Kingdom Did Not Lead to Youth Suicide Spike

    http://www.medscape.com/viewarticle/570494

     

    FDA Sources

    Safety and Efficacy NOT established in pediatric patients less than 12 years of age with Major Depressive Disorder or in pediatric patients (less than 18 years of age) with

    General Anxiety Disorder.

    http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/PediatricAdvisoryCommittee/UCM255406.pdf

     

    Apathy Syndrome, Indifference Syndrome, Emotional Blunting, Loss of Motivation

    The following articles and text snippets cover the Apathy Syndrome that is a common side-effect of SSRI’s.

     

    Emotional side-effects of selective serotonin reuptake inhibitors: qualitative study

    http://bjp.rcpsych.org/content/195/3/211.full

     

    Emotional blunting associated with SSRI-induced sexual dysfunction. Do SSRIs inhibit emotional responses?

    http://toxicpsychiatry.squarespace.com/storage/Antidep%20SSRI%20emotional%20Blunting%202002%20Opbroek.pdf

    Excerpt:  “How could SSRIs be inducing emotional blunting ? One speculative thought is that SSRIs may be reducing the function of specific brain areas involved in emotional processing. An example of such an area is the anterior cingulate. A recent study suggests that regional brain metabolism, as measured by positron emission tomography, is reduced in the anterior cingulate of depressed subjects when compared to non-depressed subjects (Kennedy et al., 1997). This cortical region is associated with emotional expression, regulation of affect, and is modulated by dopaminergic, noradrenergic, and cholinergic systems. Increases and decreases in cingulate activity have been reported during depression and following treatment (Kennedy et al., 2001). Rather than restore normal function to this area, SSRI administration has been shown to further decrease activity in the anterior cingulate cortex (Ebert and Ebmeier, 1996). Finally, another study found that noradrenergic challenge increased anterior cingulate activity (Dubini et al., 1997).”

    “In summary, emotional blunting associated with SSRI treatment may be more common than previously thought. Further study is required to determine the frequency of this phenomenon, whether it is associated primarily with SSRI antidepressants, whether usually associated with the presence of sexual dysfunction, and what the functional implications of these symptoms are. We speculate that in some patients, rather than representing a side-effect, blunting of emotions may be the central therapeutic effect of SSRIs.”

     

    Effects of paroxetine on emotional functioning and treatment awareness: a 4-week randomized placebo-controlled study in healthy clinicians.

    http://www.ncbi.nlm.nih.gov/pubmed/19826792

    4-week randomized placebo-controlled study in healthy clinicians:  Conclusion:  “This is the first study assessing the impact of a 4-week paroxetine treatment on emotional functioning in healthy psychiatrists and psychologists. The DBPX group was distinguishable from both SBPX and DBPO groups by a decrease in internal emotional experience, suggesting that two factors could be involved in the clinical response to paroxetine: a decrease in emotional feeling and treatment awareness.”

     

    Physicians Are Talking About: Selective Serotonin Reuptake Inhibitors and the Choice to Numb Out

    http://www.medscape.com/viewarticle/716929

     

    SSRI-Induced Indifference

    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989833/

     

    SSRI’s increase risk of Chronic Depression

     

    Psychiatric drug-induced Chronic Brain Impairment (CBI): Implications for long-term treatment with psychiatric medication

    http://breggin.com/index.php?option=com_docman&task=doc_download&gid=232&Itemid=37

     

    Now Antidepressant-Induced Chronic Depression Has a Name: Tardive Dysphoria

    http://www.psychologytoday.com/print/68229

     

    New Research: Antidepressants Can Cause Long-Term Depression

    http://www.huffingtonpost.com/dr-peter-breggin/antidepressants-long-term-depression_b_1077185.html

     

    SSRI’s increase risk of Diabetes

     

    Obesity, dyslipidemia, and diabetes with selective serotonin reuptake inhibitors: the Hordaland Health Study.

    http://www.ncbi.nlm.nih.gov/pubmed/17194277

     

    SSRI’s increase rate of Cancer

     

    Breast-Cancer Link to Paxil Drug Category Found in Antidepressant Research

    http://www.bloomberg.com/news/2011-04-06/breast-cancer-link-to-paxil-drug-category-found-in-antidepressant-research.html

     

    SSRI’s cause 50-60% infertility that may not reverse upon discontinuation

     

    NewYork-Presbyterian/Weill Cornell Study Shows Abnormal Sperm DNA Fragmentation in Half of Men Taking an SSRI

    http://weill.cornell.edu/news/releases/wcmc/wcmc_2009/06_11_09.shtml

     

    The Possible Impact of SSRIs on Male Sexual Function and Fertility

    http://www.psychologytoday.com/blog/you-it/200811/the-possible-impact-ssris-male-sexual-function-and-fertility

     

    SSRI’s Increase Risk of Bleeding

     

    Serotonin reuptake inhibitor antidepressants and abnormal bleeding: a review for clinicians and a reconsideration of mechanisms.

    http://www.ncbi.nlm.nih.gov/pubmed/21190637

     

    SSRI Antidepressants and Abnormal Bleeding: A Review:  Brown University

    http://www.childadolescentpsychopharm.com/sample-articles/ssri-antidepressants-abnormal-bleeding.aspx

     

    Beware bleeding with SSRIs and antiplatelets

    http://www.theheart.org/article/1286155.do

     

    SSRI’s effect on personal relationships and romance

     

    Lust, Romance, Attachment: Do the Side effects of Serotonin-Enhancing Antidepressants Jeopardize Romantic Love, Marriage, and Fertility?

    http://www.helenfisher.com/downloads/articles/18ecn.pdf

     

    SSRI’s promote bone-loss and increase hip fractures

     

    SSRI’s: Bad to the Bone

    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442753/

     

    SSRI’s Change your Brain for the Worse

     

    Depression Drugs — SSRIs — May Reorganize Brain Plasticity, New Research Suggests:  Increases anxiety and hypo and hyper activity

    http://www.sciencedaily.com/releases/2011/03/110316084425.htm

     

    The consequences of long term antidepressant treatment

    http://www.cnsforum.com/imagebank/item/desens_ssri_dpn/default.aspx

     

    SSRI’s Cause Birth Defects

    SSRI antidepressants and birth defects.

    http://www.ncbi.nlm.nih.gov/pubmed/17167929

     

    Side-effects: Pharma Industry Reported

    National Institutes of Health: Major Side Effects and Warnings

    http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=58335

     

    Side-effects: Anecdotal – Personal accounts

    Note:  Some of these anecdotal accounts are supported by research and others are only seen on web forums.  Many research studies need to be performed to investigate these effects.

    •    Caffeine-like buzz equivalent to 15 to 55 cups of coffee/day

    •    Reduced empathy

    •    Reduced social-connectedness

    •    Reduced creative drive

    •    Reduced motivation

    •    Reduced academic performance

    •    Increased introversion

    •    Increased homicidal and aggressive behavior

    •    Increased risky behaviors (dopamine circuitry / risk-reward  appears to malfunction)

    •    Pit in the stomach

    •    Dramatic increase in blood pressure (upwards of 200/100)

     

    Placebos are WONDERFUL

     

    Why Placebos Work Wonders

    http://online.wsj.com/article/SB10001424052970204720204577128873886471982.html

     

    Pharma Company-Sponsored Studies Biased

     

    Pharma Company-Sponsored Studies Biased: Meta-analysis

    www.medscape.com/viewarticle/776058

     

    SSRI Discontinuation Syndrome – SSRI’s are Addictive

    Note:  Literature suggests 14-20% become addicted.  Addiction time appears to be partially dependent on dosage and time on that dose prior to discontinuation.  Maximal addiction appears to occur after 8 weeks of usage.

     

    Selective serotonin reuptake inhibitor discontinuation syndrome:  National Institutes of Health

    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1407715/pdf/jpn00086-0041.pdf

     

    “Intoxication Anosognosia: The Spellbinding Effect of Psychiatric Drugs”, Ethical Human Psychology and Psychiatry, 8, 201-215, 2006.

    http://breggin.com/index.php?option=com_docman&task=doc_download&gid=196&Itemid=37

     

    Historical Accounts of How such a bad class of medication became so popular and financially fruitful

     

    The Prozac Backlash: Trouble in Prozac Nation

    http://www.woodymatters.com/06_updates/fortune.pdf

     

    Exposing the Dangers of Antidepressants and Other Psychotropic Drugs— Despite FDA/Psychiatric- Pharmaceutical Cover-Ups Vested Interests Inventing “Chemical Imbalance” Theory to Sell Drugs

    http://www.cchr.org/sites/default/files/Exposing_the_Dangers_of_Antidepressants_Despite_Cover-Ups.pdf

     

    Are Psychiatric Medications Making Us Sicker?

    http://blogs.scientificamerican.com/cross-check/2012/03/05/are-psychiatric-medications-making-us-sicker/

     

    A Comprehensive History of SSRI’s: Research, Science, Marketing, and Advertising

    http://www.healyprozac.com/book/introduction.pdf

     

    Document Details Plan to Promote Costly Drug: NY Times

    http://www.nytimes.com/2009/09/02/business/02drug.html?_r=0

     

    The 1997 Eli Lilly Prozac Campaign: Depression Hurts but Can Prozac Help?

    “Synthesis: An Undergraduate Journal of the History of Science: 2010” Harvard University Medical School

    http://www.fas.harvard.edu/~hsdept/docs/Synth_Iss2.pdf

     

    The Marketization of Depression: The Prescribing of SSRI Antidepressants to Women

    http://www.whp-apsf.ca/pdf/SSRIs.pdf

     

    Social Anxiety Disorder

     

    Issues and Controversies Surrounding the Diagnosis and Treatment of Social Anxiety Disorder

    http://www.medscape.org/viewarticle/771012

     

    General Articles

     

    Five Reasons not to take SSRIs

    http://www.psychologytoday.com/blog/obsessively-yours/201001/five-reasons-not-take-ssris

     

    Happy Pills or Useful Skills?

    http://www.psychologytoday.com/blog/codes-joy/201205/happy-pills-or-useful-skills

     

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