Black Cumin Seed and Cancer – the Science behind the Seed

Dr. Weeks’ Comment:  Black cumin seed is a potent ingredient in SOUL, the 3 seed drink made from seeds of anti-inflammatory plants.   Here is some of the published research articles demonstrating the anti-cancer effects of this ancient yet potent healing plant.

1.

Bioactivity-guided identification to delineate the immunomodulatory effects of methanolic extract ofNigella sativa seed on human peripheral blood mononuclear cells.

Alshatwi AA.

Chin J Integr Med. 2014 Mar 2. [Epub ahead of print]

PMID:

 24584754

[PubMed – as supplied by publisher]

Related citations

2.

Cytotoxicity of nigella sativa seed oil and extract against human lung cancer cell line.

Al-Sheddi ES, Farshori NN, Al-Oqail MM, Musarrat J, Al-Khedhairy AA, Siddiqui MA.

Asian Pac J Cancer Prev. 2014;15(2):983-7.

PMID:

 24568529

[PubMed – in process]

Free Article

Related citations

3.

Thymoquinone in the clinical treatment of cancer: Fact or fiction?

Abukhader MM.

Pharmacogn Rev. 2013 Jul;7(14):117-120. Review.

PMID:

 24347919

[PubMed – as supplied by publisher]

Free PMC Article

Related citations

4.

Baharetha HM, Nassar ZD, Aisha AF, Ahamed MB, Al-Suede FS, Abd Kadir MO, Ismail Z, Majid AM.

J Med Food. 2013 Dec;16(12):1121-30. doi: 10.1089/jmf.2012.2624.

PMID:

 24328702

[PubMed – in process]

Related citations

5.

Thymoquinone causes multiple effects, including cell death, on dividing plant cells.

Hassanien SE, Ramadan AM, Azeiz AZ, Mohammed RA, Hassan SM, Shokry AM, Atef A, Kamal KB, Rabah S, Sabir JS, Abuzinadah OA, El-Domyati FM, Martin GB, Bahieldin A.

C R Biol. 2013 Nov-Dec;336(11-12):546-56. doi: 10.1016/j.crvi.2013.10.007. Epub 2013 Nov 19.

PMID:

 24296078

[PubMed – in process]

Related citations

 

 

6.

Molecular targeting of Akt by thymoquinone promotes G(1) arrest through translation inhibition of cyclin D1 and induces apoptosis in breast cancer cells.

Rajput S, Kumar BN, Dey KK, Pal I, Parekh A, Mandal M.

Life Sci. 2013 Nov 13;93(21):783-90. doi: 10.1016/j.lfs.2013.09.009. Epub 2013 Sep 15.

PMID:

 24044882

[PubMed – indexed for MEDLINE]

Related citations

7.

Racoma IO, Meisen WH, Wang QE, Kaur B, Wani AA.

PLoS One. 2013 Sep 9;8(9):e72882. doi: 10.1371/journal.pone.0072882. eCollection 2013.

PMID:

 24039814

[PubMed – in process]

Free PMC Article

Related citations

 

8.

Thymoquinone induces mitochondria-mediated apoptosis in acute lymphoblastic leukaemia in vitro.

Salim LZ, Mohan S, Othman R, Abdelwahab SI, Kamalidehghan B, Sheikh BY, Ibrahim MY.

Molecules. 2013 Sep 12;18(9):11219-40. doi: 10.3390/molecules180911219.

PMID:

 24036512

[PubMed – indexed for MEDLINE]

Free Article

Related citations

9.

Cellular responses with thymoquinone treatment in human breast cancer cell line MCF-7.

Motaghed M, Al-Hassan FM, Hamid SS.

Pharmacognosy Res. 2013 Jul;5(3):200-6. doi: 10.4103/0974-8490.112428.

PMID:

 23900121

[PubMed]

Free PMC Article

Related citations

10.

Induction of apoptosis in melanoma A375 cells by a chloroform fraction of Centratherum anthelminticum (L.) seeds involves NF-kappaB, p53 and Bcl-2-controlled mitochondrial signaling pathways.

Looi CY, Moharram B, Paydar M, Wong YL, Leong KH, Mohamad K, Arya A, Wong WF, Mustafa MR.

BMC Complement Altern Med. 2013 Jul 10;13:166. doi: 10.1186/1472-6882-13-166.

PMID:

 23837445

[PubMed – indexed for MEDLINE]

Free PMC Article

Related citations

11.

Radioprotection by Macerated Extract of Nigella sativa in Normal Tissues of Fibrosarcoma Bearing Mice.

Velho-Pereira R, Kumar A, Pandey BN, Mishra KP, Jagtap AG.

Indian J Pharm Sci. 2012 Sep;74(5):403-14. doi: 10.4103/0250-474X.108415.

PMID:

 23716868

[PubMed]

Free PMC Article

Related citations

12.

Thymoquinone attenuates tumor growth in ApcMin mice by interference with Wnt-signaling.

Lang M, Borgmann M, Oberhuber G, Evstatiev R, Jimenez K, Dammann KW, Jambrich M, Khare V, Campregher C, Ristl R, Gasche C.

Mol Cancer. 2013 May 13;12(1):41. doi: 10.1186/1476-4598-12-41.

PMID:

 23668310

[PubMed – indexed for MEDLINE]

Free PMC Article

Related citations

13.

Thymoquinone suppresses metastasis of melanoma cells by inhibition of NLRP3 inflammasome.

Ahmad I, Muneer KM, Tamimi IA, Chang ME, Ata MO, Yusuf N.

Toxicol Appl Pharmacol. 2013 Jul 1;270(1):70-6. doi: 10.1016/j.taap.2013.03.027. Epub 2013 Apr 10.

PMID:

 23583630

[PubMed – indexed for MEDLINE]

Related citations

14.

Synthesis, characterization and anti-tumor activity of novel thymoquinone analogs against pancreaticcancer.

Yusufi M, Banerjee S, Mohammad M, Khatal S, Venkateswara Swamy K, Khan EM, Aboukameel A, Sarkar FH, Padhye S.

Bioorg Med Chem Lett. 2013 May 15;23(10):3101-4. doi: 10.1016/j.bmcl.2013.03.003. Epub 2013 Mar 14.

PMID:

 23562242

[PubMed – indexed for MEDLINE]

Related citations

15.

Methanolic extract of Nigella sativa seed inhibits SiHa human cervical cancer cell proliferation through apoptosis.

Hasan TN, Shafi G, Syed NA, Alfawaz MA, Alsaif MA, Munshi A, Lei KY, Alshatwi AA.

Nat Prod Commun. 2013 Feb;8(2):213-6.

PMID:

 23513732

[PubMed – indexed for MEDLINE]

Related citations

16.

Hormetic/cytotoxic effects of Nigella sativa seed alcoholic and aqueous extracts on MCF-7 breastcancer cells alone or in combination with doxorubicin.

Mahmoud SS, Torchilin VP.

Cell Biochem Biophys. 2013 Jul;66(3):451-60. doi: 10.1007/s12013-012-9493-4.

PMID:

 23242945

[PubMed – indexed for MEDLINE]

Related citations

17.

NADPH quinone oxidoreductase 1 mediates breast cancer cell resistance to thymoquinone-induced apoptosis.

Sutton KM, Doucette CD, Hoskin DW.

Biochem Biophys Res Commun. 2012 Sep 28;426(3):421-6. doi: 10.1016/j.bbrc.2012.08.111. Epub 2012 Aug 30.

PMID:

 22960073

[PubMed – indexed for MEDLINE]

Related citations

18.

Use of complementary and alternative medicine by patients with cancer in Saudi Arabia.

Jazieh AR, Al Sudairy R, Abulkhair O, Alaskar A, Al Safi F, Sheblaq N, Young S, Issa M, Tamim H.

J Altern Complement Med. 2012 Nov;18(11):1045-9. doi: 10.1089/acm.2011.0266. Epub 2012 Aug 20.

PMID:

 22906212

[PubMed – indexed for MEDLINE]

Related citations

19.

Can methanolic extract of Nigella sativa seed affect glyco-regulatory enzymes in experimental hepatocellular carcinoma?

Abdel-Hamid NM, Abdel-Ghany MI, Nazmy MH, Amgad SW.

Environ Health Prev Med. 2013 Jan;18(1):49-56. doi: 10.1007/s12199-012-0292-8. Epub 2012 Jul 6.

PMID:

 22767221

[PubMed – indexed for MEDLINE]

Free PMC Article

Related citations

20.

Characterization of thymoquinone binding to human α₁-acid glycoprotein.

Lupidi G, Camaioni E, Khalifé H, Avenali L, Damiani E, Tanfani F, Scirè A.

J Pharm Sci. 2012 Jul;101(7):2564-73. doi: 10.1002/jps.23138. Epub 2012 Mar 29.

PMID:

 22467430

[PubMed – indexed for MEDLINE]

Related citations

21.

Modulation of apoptosis in human hepatocellular carcinoma (HepG2 cells) by a standardized herbal decoction of Nigella sativa seeds, Hemidesmus indicus roots and Smilax glabra rhizomes with anti- hepatocarcinogenic effects.

Samarakoon SR, Thabrew I, Galhena PB, Tennekoon KH.

BMC Complement Altern Med. 2012 Mar 29;12:25. doi: 10.1186/1472-6882-12-25.

PMID:

 22458551

[PubMed – indexed for MEDLINE]

Free PMC Article

Related citations

22.

Thymoquinone inhibits growth and augments 5-fluorouracil-induced apoptosis in gastric cancer cells both in vitro and in vivo.

Lei X, Lv X, Liu M, Yang Z, Ji M, Guo X, Dong W.

Biochem Biophys Res Commun. 2012 Jan 13;417(2):864-8. doi: 10.1016/j.bbrc.2011.12.063. Epub 2011 Dec 20.

PMID:

 22206670

[PubMed – indexed for MEDLINE]

Related citations

23.

Anticancer activity of Nigella sativa (black seed) – a review.

Randhawa MA, Alghamdi MS.

Am J Chin Med. 2011;39(6):1075-91. Review.

PMID:

 22083982

[PubMed – indexed for MEDLINE]

Related citations

24.

Thymoquinone, the active ingredient of Nigella sativa seeds, enhances survival and activity of antigen-specific CD8-positive T cells in vitro.

Salem ML, Alenzi FQ, Attia WY.

Br J Biomed Sci. 2011;68(3):131-7.

PMID:

 21950205

[PubMed – indexed for MEDLINE]

Related citations

25.

Anti-neoplastic agent thymoquinone induces degradation of α and β tubulin proteins in humancancer cells without affecting their level in normal human fibroblasts.

Alhosin M, Ibrahim A, Boukhari A, Sharif T, Gies JP, Auger C, Schini-Kerth VB.

Invest New Drugs. 2012 Oct;30(5):1813-9. doi: 10.1007/s10637-011-9734-1. Epub 2011 Sep 1.

PMID:

 21881916

[PubMed – indexed for MEDLINE]

Related citations

26.

Antioxidant oils and Salmonella enterica Typhimurium reduce tumor in an experimental model of hepatic metastasis.

Sorenson BS, Banton KL, Augustin LB, Leonard AS, Saltzman DA.

Onco Targets Ther. 2011;4:59-69. doi: 10.2147/OTT.S17081. Epub 2011 May 30.

PMID:

 21691578

[PubMed]

Free PMC Article

Related citations

27.

Radiosensitization in human breast carcinoma cells by thymoquinone: role of cell cycle and apoptosis.

Velho-Pereira R, Kumar A, Pandey BN, Jagtap AG, Mishra KP.

Cell Biol Int. 2011 Oct;35(10):1025-9. doi: 10.1042/CBI20100701.

PMID:

 21557727

[PubMed – indexed for MEDLINE]

Related citations

28.

Anticancer activities of Nigella sativa (black cumin).

Khan MA, Chen HC, Tania M, Zhang DZ.

Afr J Tradit Complement Altern Med. 2011;8(5 Suppl):226-32. doi: 10.4314/ajtcam.v8i5S.10. Epub 2011 Jul 3. Review.

PMID:

 22754079

[PubMed – indexed for MEDLINE]

Free PMC Article

Related citations

29.

The protective effect of thymoquinone against sepsis syndrome morbidity and mortality in mice.

Alkharfy KM, Al-Daghri NM, Al-Attas OS, Alokail MS.

Int Immunopharmacol. 2011 Feb;11(2):250-4. doi: 10.1016/j.intimp.2010.11.032. Epub 2010 Dec 9.

PMID:

 21145996

[PubMed – indexed for MEDLINE]

Related citations

30.

Thymoquinone up-regulates PTEN expression and induces apoptosis in doxorubicin-resistant human breast cancer cells.

Arafa el-SA, Zhu Q, Shah ZI, Wani G, Barakat BM, Racoma I, El-Mahdy MA, Wani AA.

Mutat Res. 2011 Jan 10;706(1-2):28-35. doi: 10.1016/j.mrfmmm.2010.10.007. Epub 2010 Oct 30.

PMID:

 21040738

[PubMed – indexed for MEDLINE]

Free PMC Article

Related citations

31.

Review on molecular and therapeutic potential of thymoquinone in cancer.

Banerjee S, Padhye S, Azmi A, Wang Z, Philip PA, Kucuk O, Sarkar FH, Mohammad RM.

Nutr Cancer. 2010;62(7):938-46. doi: 10.1080/01635581.2010.509832. Review.

PMID:

 20924969

[PubMed – indexed for MEDLINE]

Related citations

32.

Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis.

Abusnina A, Alhosin M, Keravis T, Muller CD, Fuhrmann G, Bronner C, Lugnier C.

Cell Signal. 2011 Jan;23(1):152-60. doi: 10.1016/j.cellsig.2010.08.015. Epub 2010 Aug 31.

PMID:

 20807569

[PubMed – indexed for MEDLINE]

Related citations

34.

Nigella sativa: reduces the risk of various maladies.

Butt MS, Sultan MT.

Crit Rev Food Sci Nutr. 2010 Aug;50(7):654-65. doi: 10.1080/10408390902768797. Review.

PMID:

 20694927

[PubMed – indexed for MEDLINE]

Related citations

35.

Quantitative analysis and toxicity determination of artifacts originated in a Thai traditional medicine Prasaplai.

Tangyuenyongwatana P, Gritsanapan W.

Pharm Biol. 2010 May;48(5):584-8. doi: 10.3109/13880200903214223.

PMID:

 20645803

[PubMed – indexed for MEDLINE]

Related citations

36.

Comparative study of Nigella Sativa and triple therapy in eradication of Helicobacter Pylori in patients with non-ulcer dyspepsia.

Salem EM, Yar T, Bamosa AO, Al-Quorain A, Yasawy MI, Alsulaiman RM, Randhawa MA.

Saudi J Gastroenterol. 2010 Jul-Sep;16(3):207-14. doi: 10.4103/1319-3767.65201.

PMID:

 20616418

[PubMed – indexed for MEDLINE]

Free PMC Article

Related citations

37.

Nigella sativa modulates splenocyte proliferation, Th1/Th2 cytokine profile, macrophage function and NK anti-tumor activity.

Majdalawieh AF, Hmaidan R, Carr RI.

J Ethnopharmacol. 2010 Sep 15;131(2):268-75. doi: 10.1016/j.jep.2010.06.030. Epub 2010 Jun 30.

PMID:

 20600757

[PubMed – indexed for MEDLINE]

Related citations

38.

Thymoquinone and cisplatin as a therapeutic combination in lung cancer: In vitro and in vivo.

Jafri SH, Glass J, Shi R, Zhang S, Prince M, Kleiner-Hancock H.

J Exp Clin Cancer Res. 2010 Jul 1;29:87. doi: 10.1186/1756-9966-29-87.

PMID:

 20594324

[PubMed – indexed for MEDLINE]

Free PMC Article

Related citations

39.

Studies on molecular mechanisms of growth inhibitory effects of thymoquinone against prostatecancer cells: role of reactive oxygen species.

Koka PS, Mondal D, Schultz M, Abdel-Mageed AB, Agrawal KC.

Exp Biol Med (Maywood). 2010 Jun;235(6):751-60. doi: 10.1258/ebm.2010.009369.

PMID:

 20511679

[PubMed – indexed for MEDLINE]

Related citations

40.

Effects of thymoquinone in the expression of mucin 4 in pancreatic cancer cells: implications for the development of novel cancer therapies.

Torres MP, Ponnusamy MP, Chakraborty S, Smith LM, Das S, Arafat HA, Batra SK.

Mol Cancer Ther. 2010 May;9(5):1419-31. doi: 10.1158/1535-7163.MCT-10-0075. Epub 2010 Apr 27.

PMID:

 20423995

[PubMed – indexed for MEDLINE]

Free PMC Article

Related citations

41.

Structure-activity studies on therapeutic potential of Thymoquinone analogs in pancreatic cancer.

Banerjee S, Azmi AS, Padhye S, Singh MW, Baruah JB, Philip PA, Sarkar FH, Mohammad RM.

Pharm Res. 2010 Jun;27(6):1146-58. doi: 10.1007/s11095-010-0145-3. Epub 2010 Apr 27.

PMID:

 20422266

[PubMed – indexed for MEDLINE]

Free PMC Article

Related citations

42.

Terpene conjugates of the Nigella sativa seed-oil constituent thymoquinone with enhanced efficacy in cancer cells.

Effenberger K, Breyer S, Schobert R.

Chem Biodivers. 2010 Jan;7(1):129-39. doi: 10.1002/cbdv.200900328.

PMID:

 20087986

[PubMed – indexed for MEDLINE]

Related citations

43.

Induction of apoptosis in HeLa cells by chloroform fraction of seed extracts of Nigella sativa.

Shafi G, Munshi A, Hasan TN, Alshatwi AA, Jyothy A, Lei DK.

Cancer Cell Int. 2009 Nov 27;9:29. doi: 10.1186/1475-2867-9-29.

PMID:

 19943925

[PubMed]

Free PMC Article

Related citations

44.

Anti-inflammatory effects of the Nigella sativa seed extract, thymoquinone, in pancreatic cancercells.

Chehl N, Chipitsyna G, Gong Q, Yeo CJ, Arafat HA.

HPB (Oxford). 2009 Aug;11(5):373-81. doi: 10.1111/j.1477-2574.2009.00059.x.

PMID:

 19768141

[PubMed]

Free PMC Article

Related citations

45.

Oral and intraperitoneal LD50 of thymoquinone, an active principle of Nigella sativa, in mice and rats.

Al-Ali A, Alkhawajah AA, Randhawa MA, Shaikh NA.

J Ayub Med Coll Abbottabad. 2008 Apr-Jun;20(2):25-7.

PMID:

 19385451

[PubMed – indexed for MEDLINE]

Related citations

46.

Effects of thymoquinone-fatty acid conjugates on cancer cells.

Breyer S, Effenberger K, Schobert R.

ChemMedChem. 2009 May;4(5):761-8. doi: 10.1002/cmdc.200800430.

PMID:

 19322799

[PubMed – indexed for MEDLINE]

Related citations

47.

Effects of thymoquinone and selenium on the proliferation of mg 63 cells in tissue culture.

Barron J, Benghuzzi H, Tucci M.

Biomed Sci Instrum. 2008;44:434-40.

PMID:

 19141954

[PubMed – in process]

Related citations

48.

From here to eternity – the secret of Pharaohs: Therapeutic potential of black cumin seeds and beyond.

Padhye S, Banerjee S, Ahmad A, Mohammad R, Sarkar FH.

Cancer Ther. 2008;6(b):495-510.

PMID:

 19018291

[PubMed]

Free PMC Article

Related citations

49.

Plant crude extracts could be the solution: extracts showing in vivo antitumorigenic activity.

Amara AA, El-Masry MH, Bogdady HH.

Pak J Pharm Sci. 2008 Apr;21(2):159-71.

PMID:

 18390447

[PubMed – indexed for MEDLINE]

Related citations

50.

Anti-tumor properties of blackseed (Nigella sativa L.) extracts.

Ait Mbarek L, Ait Mouse H, Elabbadi N, Bensalah M, Gamouh A, Aboufatima R, Benharref A, Chait A, Kamal M, Dalal A, Zyad A.

Braz J Med Biol Res. 2007 Jun;40(6):839-47.

PMID:

 17581684

[PubMed – indexed for MEDLINE]

Free Article

Related citations

51.

A comparison of 5-fluorouracil and natural chemotherapeutic agents, EGCG and thymoquinone, delivered by sustained drug delivery on colon cancer cells.

Norwood AA, Tucci M, Benghuzzi H.

Biomed Sci Instrum. 2007;43:272-7.

PMID:

 17487093

[PubMed – indexed for MEDLINE]

Related citations

52.

Effect of spices on lipid metabolism in 1,2-dimethylhydrazine-induced rat colon carcinogenesis.

Nalini N, Manju V, Menon VP.

J Med Food. 2006 Summer;9(2):237-45.

PMID:

 16822210

[PubMed – indexed for MEDLINE]

Related citations

53.

Assessment of cellular responses to oxidative stress using MCF-7 breast cancer cells, black seed(N. Sativa L.) extracts and H2O2.

Farah IO.

Int J Environ Res Public Health. 2005 Dec;2(3-4):411-9.

PMID:

 16819096

[PubMed – indexed for MEDLINE]

Free Article

Related citations

54.

Comparison of potential chemotherapeutic agents, 5-fluoruracil, green tea, and thymoquinone on colon cancer cells.

Norwood AA, Tan M, May M, Tucci M, Benghuzzi H.

Biomed Sci Instrum. 2006;42:350-6.

PMID:

 16817633

[PubMed – indexed for MEDLINE]

Related citations

55.

A long-term investigation of the anti-hepatocarcinogenic potential of an indigenous medicine comprised of Nigella sativa, Hemidesmus indicus and Smilax glabra.

Iddamaldeniya SS, Thabrew MI, Wickramasinghe SM, Ratnatunge N, Thammitiyagodage MG.

J Carcinog. 2006 May 9;5:11.

PMID:

 16684351

[PubMed]

Free PMC Article

Related citations

56.

Herbal melanin modulates tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6) and vascular endothelial growth factor (VEGF) production.

El-Obeid A, Al-Harbi S, Al-Jomah N, Hassib A.

Phytomedicine. 2006 May;13(5):324-33. Epub 2005 Sep 19.

PMID:

 16635740

[PubMed – indexed for MEDLINE]

Related citations

57.

Cytotoxic effects of a decoction of Nigella sativa, Hemidesmus indicus and Smilax glabra on human hepatoma HepG2 cells.

Thabrew MI, Mitry RR, Morsy MA, Hughes RD.

Life Sci. 2005 Aug 5;77(12):1319-30.

PMID:

 15916774

[PubMed – indexed for MEDLINE]

Related citations

58.

The effects of isolated antioxidants from black seed on the cellular metabolism of A549 cells.

Farah N, Benghuzzi H, Tucci M, Cason Z.

Biomed Sci Instrum. 2005;41:211-6.

PMID:

 15850107

[PubMed – indexed for MEDLINE]

Related citations

59.

Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancercells via a p53-dependent mechanism.

Gali-Muhtasib H, Diab-Assaf M, Boltze C, Al-Hmaira J, Hartig R, Roessner A, Schneider-Stock R.

Int J Oncol. 2004 Oct;25(4):857-66.

PMID:

 15375533

[PubMed – indexed for MEDLINE]

Related citations

60.

Immunosuppressive and cytotoxic properties of Nigella sativa.

Islam SN, Begum P, Ahsan T, Huque S, Ahsan M.

Phytother Res. 2004 May;18(5):395-8.

PMID:

 15174000

[PubMed – indexed for MEDLINE]

Related citations

61.

Protection against diethylnitrosoamine-induced hepatocarcinogenesis by an indigenous medicine comprised of Nigella sativa, Hemidesmus indicus and Smilax glabra: a preliminary study.

Iddamaldeniya SS, Wickramasinghe N, Thabrew I, Ratnatunge N, Thammitiyagodage MG.

J Carcinog. 2003 Oct 18;2(1):6.

PMID:

 14613573

[PubMed – as supplied by publisher]

Free PMC Article

Related citations

62.

Chemopreventive potential of volatile oil from black cumin (Nigella sativa L.) seeds against rat colon carcinogenesis.

Salim EI, Fukushima S.

Nutr Cancer. 2003;45(2):195-202.

PMID:

 12881014

[PubMed – indexed for MEDLINE]

Related citations

63.

The role of black seed in the proliferation and biochemical marker levels of Hep-2 cells.

Hansen JT, Benghuzzi H, Tucci M, Cason Z.

Biomed Sci Instrum. 2003;39:371-6.

PMID:

 12724922

[PubMed – indexed for MEDLINE]

Related citations

64.

Delayed apoptosis upon the treatment of Hep-2 cells with black seed.

Corder C, Benghuzzi H, Tucci M, Cason Z.

Biomed Sci Instrum. 2003;39:365-70.

PMID:

 12724921

[PubMed – indexed for MEDLINE]

Related citations

65.

Effect of Nigella sativa (N. sativa L.) and oxidative stress on the survival pattern of MCF-7 breastcancer cells.

Farah IO, Begum RA.

Biomed Sci Instrum. 2003;39:359-64.

PMID:

 12724920

[PubMed – indexed for MEDLINE]

Related citations

66.

Intracellular glutathione depletion and reactive oxygen species generation are important in alpha-hederin-induced apoptosis of P388 cells.

Swamy SM, Huat BT.

Mol Cell Biochem. 2003 Mar;245(1-2):127-39.

PMID:

 12708752

[PubMed – indexed for MEDLINE]

Related citations

67.

Inhibitory effects of thymoquinone against 20-methylcholanthrene-induced fibrosarcoma tumorigenesis.

Badary OA, Gamal El-Din AM.

Cancer Detect Prev. 2001;25(4):362-8.

PMID:

 11531013

[PubMed – indexed for MEDLINE]

Related citations

68.

Cytotoxic and immunopotentiating effects of ethanolic extract of Nigella sativa L. seeds.

Swamy SM, Tan BK.

J Ethnopharmacol. 2000 Apr;70(1):1-7.

PMID:

 10720783

[PubMed – indexed for MEDLINE]

Related citations

69.

Inhibition of benzo(a)pyrene-induced forestomach carcinogenesis in mice by thymoquinone.

Badary OA, Al-Shabanah OA, Nagi MN, Al-Rikabi AC, Elmazar MM.

Eur J Cancer Prev. 1999 Oct;8(5):435-40.

PMID:

 10548399

[PubMed – indexed for MEDLINE]

Related citations

70.

The in vitro anti-tumor activity of some crude and purified components of blackseed, Nigella sativaL.

Worthen DR, Ghosheh OA, Crooks PA.

Anticancer Res. 1998 May-Jun;18(3A):1527-32.

PMID:

 9673365

[PubMed – indexed for MEDLINE]

Related citations

71.

Antitumour principles from Nigella sativa seeds.

Salomi NJ, Nair SC, Jayawardhanan KK, Varghese CD, Panikkar KR.

Cancer Lett. 1992 Mar 31;63(1):41-6.

PMID:

 1555206

[PubMed – indexed for MEDLINE]

Related citations

72.

Modulatory effects of Crocus sativus and Nigella sativa extracts on cisplatin-induced toxicity in mice.

Nair SC, Salomi MJ, Panikkar B, Panikkar KR.

J Ethnopharmacol. 1991 Jan;31(1):75-83.

PMID:

 2030595

[PubMed – indexed for MEDLINE]

Related citations

73.

Inhibitory effects of Nigella sativa and saffron (Crocus sativus) on chemical carcinogenesis in mice.

Salomi MJ, Nair SC, Panikkar KR.

Nutr Cancer. 1991;16(1):67-72.

PMID:

 1923908

[PubMed – indexed for MEDLINE]

Related citations

Share This Post

Dr. Weeks’ Comment:  Black cumin seed is a potent ingredient in SOUL, the 3 seed drink made from seeds of anti-inflammatory plants.   Here is some of the published research articles demonstrating the anti-cancer effects of this ancient yet potent healing plant. 1. Bioactivity-guided identification to delineate the immunomodulatory effects of methanolic extract ofNigella sativa seed on…
&source=WeeksMD">