Bee Venom and Prostate Cancer

Dr. Weeks’ Comment: PUB MED is a fabulous resource.   Here we see current work with bee venom and prostate cancer.   The real Sting!

 

Anticancer peptide NK-2 targets cell surface sulphated glycans rather than sialic acids.

Gross S, Andrä J.

Biol Chem. 2012 Aug;393(8):817-27. doi: 10.1515/hsz-2012-0136.

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Bee venom in cancer therapy.

Oršolić N.

Cancer Metastasis Rev. 2012 Jun;31(1-2):173-94. doi: 10.1007/s10555-011-9339-3. Review.

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Anti-cancer effect of bee venom in prostate cancer cells through activation of caspase pathway via inactivation of NF-κB.

Park MH, Choi MS, Kwak DH, Oh KW, Yoon do Y, Han SB, Song HS, Song MJ, Hong JT.

Prostate. 2011 Jun 1;71(8):801-12. doi: 10.1002/pros.21296. Epub 2010 Nov 17.

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Targeting the cancer stroma with a fibroblast activation protein-activated promelittin protoxin.

LeBeau AM, Brennen WN, Aggarwal S, Denmeade SR.

Mol Cancer Ther. 2009 May;8(5):1378-86. doi: 10.1158/1535-7163.MCT-08-1170. Epub 2009 May 5.

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Immune response to lytic peptides conjugated to a betaCG fragment in treated BALB/C mice.

Bogacki M, Enright FM, Todd WJ, Hansel W.

Reprod Biol. 2008 Jul;8(2):135-47.

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Therapeutic application of anti-arthritis, pain-releasing, and anti-cancer effects of bee venom and its constituent compounds.

Son DJ, Lee JW, Lee YH, Song HS, Lee CK, Hong JT.

Pharmacol Ther. 2007 Aug;115(2):246-70. Epub 2007 May 6. Review

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Conjugates of lytic peptides and LHRH or betaCG target and cause necrosis of prostate cancers and metastases.

Hansel W, Leuschner C, Enright F.

Mol Cell Endocrinol. 2007 Apr 15;269(1-2):26-33. Epub 2007 Feb 15. Review.

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Antitumor action and immune activation through cooperation of bee venom secretory phospholipase A2 and phosphatidylinositol-(3,4)-bisphosphate.

Putz T, Ramoner R, Gander H, Rahm A, Bartsch G, Thurnher M.

Cancer Immunol Immunother. 2006 Nov;55(11):1374-83. Epub 2006 Feb 17.

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Targeting breast and prostate cancers through their hormone receptors.

Leuschner C, Hansel W.

Biol Reprod. 2005 Nov;73(5):860-5. Epub 2005 Jul 20. Review.

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Biodistributions of intact monoclonal antibodies and fragments of BLCA-38, a new prostate cancerdirected antibody.

Carter T, Sterling-Levis K, Ow K, Doughty L, Hattarki M, Shapira D, Hewish D, Kortt AA, Russell PJ.

Cancer Immunol Immunother. 2004 Jun;53(6):533-42. Epub 2004 Jan 13.

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Cytotoxic properties of immunoconjugates containing melittin-like peptide 101 against prostate cancer: in vitro and in vivo studies.

Russell PJ, Hewish D, Carter T, Sterling-Levis K, Ow K, Hattarki M, Doughty L, Guthrie R, Shapira D, Molloy PL, Werkmeister JA, Kortt AA.

Cancer Immunol Immunother. 2004 May;53(5):411-21. Epub 2004 Jan 13.

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Targeted destruction of normal and cancer cells through lutropin/choriogonadotropin receptors using Hecate-betaCG conjugate.

Zaleska M, Bodek G, Jana B, Hansel W, Ziecik AJ.

Exp Clin Endocrinol Diabetes. 2003 May;111(3):146-53.

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Conformational and thermodynamic properties of peptide binding to the human S100P protein.

Gribenko AV, Guzmán-Casado M, Lopez MM, Makhatadze GI.

Protein Sci. 2002 Jun;11(6):1367-75.

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