Dr. Weeks; Comment: Finally oncologists are focusing on… “a new therapy that may prevent cancer relapse”… The best option is to eat the seeds – whole crushed organic non-GMO anti-inflammatory seeds in particular
UC San Diego and GSK Collaborate to Eradicate Cancer Stem Cells, Treat Leukemia
First California institution selected to participate in GSK’s bench-to-bedside academia-industry collaboration program
July 08, 2015
Researchers at the University of California, San Diego School of Medicine and Moores Cancer Center are working with GSK on a bench-to-bedside project to treat leukemia and other diseases by eliminating cancer stem cells. The collaboration is part of GSK’s Discovery Partnerships with Academia (DPAc) program, where academic partners become core members of drug-hunting teams….
The UC San Diego-GSK DPAc team will collaborate to discover and develop a new therapeutic compound that inhibits RNA editing, a process cells use to enhance RNA diversity prior to translating genetic information into proteins. Jamieson’s group has shown that uncontrolled RNA editing helps cancer stem cells self-renew, making more malignant cells, in chronic myeloid leukemia and other blood cancers. Cancer stem cells can become dormant and evade chemotherapy and then activate again later, causing relapse of leukemia and other cancers and allowing tumors to resist treatment.
“The problem with leukemia is that in many cases while we can control the symptoms of disease, we can’t completely eradicate it because current therapies don’t block cancer stem cell self-renewal. Enhanced RNA editing is like a cancer stem cell engine, and with this collaboration we want to turn that engine off,” said Jamieson, who is also deputy director of the Sanford Stem Cell Clinical Center and director of stem cell research at UC San Diego Moores Cancer Center. “We’re very fortunate to have this opportunity to work completely in step with a highly adept, dynamic company to take the RNA editing target idea from design to delivery of a new therapy that may prevent cancer relapse.”
“Groundbreaking research on the basic behavior of stem cells ”” during human development and in the pathology of disease ”” has long been one of our strengths at UC San Diego,” said Goldstein, who is also scientific director of the Sanford Consortium for Regenerative Medicine and director of the Sanford Stem Cell Clinical Center. “Now, those fundamental studies are paying off, as we begin to apply that information in the development of new therapies.”