Patented IL-8 blockers and cancer metastasis – a new spin on an old idea

Dr. Weeks’ Comment: A new (and patented) spin on the old story that anti-inflammatory agents are the secret to stoping the spread of cancer is on trial and bears watching. Meanwhile, review what I have lectured about for the past 8 years regarding the need to use “centisble” anti-inflammatory agents as adjunctive care. in brief – all human tissue (healthy and cancerous) once injured seek to repair themselves by secreting an inflammatory cytokine – IL-8 – which recruits healthy, undifferentiated stem cells to migrate to the site of injury and become the tissue which is injured. This is only one example of how we are indeed “fearfully and wonderfully made”.  This is wonderful when the injured tissue is something you want more of: a broken bone to heal, a gastric ulcer to mend…  but when the source of the IL-8 is cancerous tissue, the recruited stem cells become….. cancer STEM cells! (The most lethal cancer cell of all and the single cell responsible for metastatic and recurrence, years later, of cancer. THIS is the cancer cell your oncologist should be targeting and not the relatively benign cancer TUMOR cells!)  So eat the seed because selected seeds are the safest, most effective and most cost-effective (hence the term “centsible”) anti-inflammatory option available.

 “…Based on amounting research pointing to IL-8 being an important driver of malignant tumors, HuMax-IL8 was taken into development by Cormorant. HuMax-IL8, is a fully human monoclonal antibody formerly developed at Genmab…”

Targeting  HuMax-IL8 in Patients With Advanced

Solid Tumors Ongoing at the NCIHuMax-IL8:

A First in Class Immuno-Oncology Drug With the Potential to Inhibit Tumor Immunosuppression as Well as Cancer Stem Cells and Metastasis.

Cormorant Pharmaceuticals in collaboration with the National Cancer Institute (NCI), Bethesda, MD has started enrollment of patients into a phase Ib clinical trial of HuMax-IL8. HuMax-IL8 is a monoclonal antibody therapy targeting interleukin-8 (IL-8). IL-8 has been shown to be upregulated in many different solid tumors and is involved in the tumor immunosuppression. Inhibiting IL-8 can potentially inhibit the tumor’s ability to suppress the patient’s own immune system from attacking the tumor. IL-8 has also been shown to be involved in aggressive aspects of tumor development, such as metastasis and cancer stem cell renewal.

The objectives of the trial are to establish safety and the optimal dose of HuMax-IL8 in cancer patients. Moreover, the potential effects of HuMax-IL8 on tumor immunosuppression, metastasis and cancer stem cell renewal will be documented through extensive biomarker measurements.

As of today, the patients in the first dose cohort have been enrolled and treated for at least 4 weeks at the NCI, and the decision was made to start enrollment in the second dose cohort. Patients with metastatic or locally advanced solid tumors are eligible.

Also today, Maarten de Château, MD PhD, the CEO of Cormorant said: “Plans are to advance the project into multiple combination trials pending completion of the dose escalation part of the ongoing phase I trial. HuMax-IL8 will then potentially be combined with a PD-1/PD-L1 inhibitor, cancer vaccine and with chemotherapy in breast, lung and other cancers.”

Cormorant Pharmaceuticals is a biopharmaceutical company, based at the Karolinska Institute Science Park in Stockholm, Sweden. Based on amounting research pointing to IL-8 being an important driver of malignant tumors, HuMax-IL8 was taken into development by Cormorant. HuMax-IL8, is a fully human monoclonal antibody formerly developed at Genmab. A clinical trial in palmoplantar pustulosis (PPP) patients was successfully conducted by Genmab and the drug has potential application in autoimmune diseases, besides oncology.

For more information on Cormorant and HuMax-IL8 visit our website: http://www.cormorantpharma.com.

Trial information can be found at: https://clinicaltrials.gov/ct2/show/NCT02536469.

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Dr. Weeks’ Comment: A new (and patented) spin on the old story that anti-inflammatory agents are the secret to stoping the spread of cancer is on trial and bears watching. Meanwhile, review what I have lectured about for the past 8 years regarding the need to use “centisble” anti-inflammatory agents as adjunctive care. in brief…
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