Black Cumin Seed and male fertility

Dr. Weeks’ Comment: Infertility in woman is often addressed with real hormone therapy – transdermal progesterone in particular –  but what about in men?  Many factors can cause deterioration of sperm production but – and this is a key concept – whatever the insult, the damage is done by excessive chronic inflammation. That brings us to Seeds of Eden – the anti-inflammatory crushed whole seeds comprised to a great extent by black cumin seed.  Want health kids?  Eat the (organic) seeds!

“…We believe that further preclinical research into the utility of TQ may indicate its usefulness as a potential treatment on the spermatogenesis after testicular injury caused by chronic toluene exposure in rats…”

Toxicol Ind Health. 2011 Mar;27(2):155-66. doi: 10.1177/0748233710382541. Epub 2010 Sep 13.

Thymoquinone reestablishes spermatogenesis after testicular injury caused by chronic toluene exposure in rats.

Abstract

The aim of this study was designed to evaluate the possible protective effects of thymoquinone (TQ) on the spermatogenesis after testicular injury caused by chronic toluene exposure in rats. The rats were randomly allotted into one of three experimental groups: control, toluene-treated and toluene treated with TQ; each group contained 10 animals. Control group received 1 mL serum physiologic and toluene treatment was performed by inhalation of 3000 ppm toluene, in an 8-hour/day and 6-day/week order for 12 weeks. The rats in TQ-treated group was given TQ (50 mg/kg body weight) once a day orally for 12 weeks starting just after toluene exposure. Tissue samples were obtained for histopathological investigation. To date, no histopathological changes of testis in rats after chronic toluene exposure by TQ treatment have been reported. Spermatogenesis and mean seminiferous tubule diameter (MSTD) were significantly decreased in toluene treated groups when compared to the control group. Furthermore, the TQ-treated animals showed an improved histological appearance in toluene-treated group. Our data indicate a significant reduction in the activity of in situ identification of apoptosis using terminal dUTP nick end-labeling (TUNEL), endothelial nitric oxide synthase (eNOS), inducible nitric oxide synthase (iNOS) and there was a rise in the expression of proliferating cell nuclear antigen (PCNA) in testis tissues of the toluene-treated group with TQ therapy. Electron microscopy of the testes of the rats demonstrated that pretreatment with TQ was particularly effective in preventing the mitochondrial degeneration, dilatation of smooth endoplasmic reticulum (SER) and enlarged intercellular spaces in both Sertoli and spermatid cells in the toluene-treated animals. We believe that further preclinical research into the utility of TQ may indicate its usefulness as a potential treatment on the spermatogenesis after testicular injury caused by chronic toluene exposure in rats.

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Dr. Weeks’ Comment: Infertility in woman is often addressed with real hormone therapy – transdermal progesterone in particular –  but what about in men?  Many factors can cause deterioration of sperm production but – and this is a key concept – whatever the insult, the damage is done by excessive chronic inflammation. That brings us…
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