Dr. Weeks Comment: The old saying is that the research is not done until the paper is published. We can amend that wisdom and follows: “The research isn’t done until the paper is published and read!”
Here we have some scientists “discovering” the benefits of antabuse 6 years after I lectured on the topic of antabuse and other agents which remedy cancer STEM cells. Read the articles here
Upon this age that never speaks its mind,
This furtive age, this age endowed with power
To wake the moon with footsteps, fit an oar
Into the rowlocks of the wind, and find
What swims before his prow, what swirls behind—
Upon this gifted age in its dark hour,
Rains from the sky a meteoric shower
Of facts . . . they lie unquestioned, uncombined.
Wisdom enough to leech us of our ill
Is daily spun; but there exists no loom
To weave it into fabric. . .
Let’s all communicate better!
PS the other thing which reverses chemotherapy resistance is pre-dosing with insulin before giving chemotherapy….
Scientists have had positive results from a laboratory-based study using a well-known alcohol aversion drug to try to combat chemotherapy resistance in the most common type of lung cancer, non-small cell lung cancer (NSCLC). The findings from the scientists at Trinity College Dublin and St James’s Hospital, Dublin, Ireland, have been published in the leading international journal Oncotarget.
Chemotherapy forms the backbone of many treatment plans for lung cancer patients, however, treatment resistance has become a significant clinical challenge. While chemotherapy kills the majority of tumour cells within a tumour, some types of cancer cells, called cancer stem cells, continue to grow and divide and contribute to the development of drug resistance. This results in tumour recurrence or secondary tumours which often prove fatal.
The scientists from the Trinity Translational Medicine Institute at St James’s Hospital Dublin, in collaboration with the Cancer Stem Cell Group, Coombe Hospital, Dublin, found that lung cancer cells that have high levels of ALDH activity, a recently identified marker of cancer stem cells became resistant to chemotherapy. This induces the growth and expansion of a drug-resistant population of lung cancer cells, allowing the cancer cells to survive the effects of treatment. These findings may help explain why a large number of lung cancer patients receiving this type of chemotherapy eventually relapse resulting in progression of their disease.
The FDA-approved alcohol aversion drug Disulfiram (Antabuse), which has been used to treat alcohol addiction for over sixty years, works against ALDH by restricting its activity. Upon alcohol consumption, it prevents the body from metabolising alcohol and makes the person feel sick. When it comes to cancer cells, the drug was found to be effective in inhibiting the activity of ALDH, which resulted in decreased tumour cell growth and increased killing of lung cancer stem cells. The research team at Trinity and St James’s found that the alcohol aversion drug Disulfiram in combination with chemotherapy, was significantly more effective in killing drug resistant lung cancer stem cells compared to treatment with the chemotherapy alone.
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