Dr. Weeks’ Comment: Just to be clear – the first line of this abstract tells the truth :
“Cancer stem cells (CSCs) are responsible for drug resistance, metastasis and recurrence of cancers.”
Yet your oncologist is not talking with you about cancer STEM cells. Why? Because the money is in targeting cancer TUMOR cells.
What is the difference? Cancer TUMOR cells are the symptom of the cancer PROCESS and cancer STEM cells are the instrument which creates and spreads cancer. Eat whole organic non-GMO seeds and supporting anti-inflammatory agents to remedy your cancer STEM cells.
Metallo-supramolecular complexes enantioselectively eradicate cancer stem cells in vivo
Cancer stem cells (CSCs) are responsible for drug resistance, metastasis and recurrence of cancers. However, there is still no clinically approved drug that can effectively eradicate CSCs. Thus, it is crucial and important to develop specific CSC-targeting agents. Chiral molecular recognition of DNA plays an important role in rational drug design. Among them, poly-morphic telomeric G-quadruplex DNA has received much attention due to its significant roles in telomerase activity and chromosome stability.
Herein, we find that one enantiomer of zinc-finger-like chiral metallohelices, [Ni2L3]4+-P, a telomeric G-quadruplex-targeting ligand, can preferentially reduce cell growth in breast CSCs compared to the bulk cancer cells. In contrast, its enantiomer, [Ni2L3]4+-M, has little effect on both populations. Further studies indicate that [Ni2L3]4+-P can repress CSC properties and induce apoptosis in breast CSCs. This is different to the bulk cancer cells. The inhibition of breast CSC traits is involved in the nuclear translocation of hTERT. The apoptosis is associated with the induction of telomere uncapping, telomere DNA damage and the degradation of 3′-overhang. Moreover, [Ni2L3]4+-P, but not [Ni2L3]4+-M, has the ability to reduce tumourigenesis of breast CSCs in vivo. To our knowledge, this is the first report that chiral complexes show significant enantio-selectivity on eradicating CSCs.