Monday, 17 December 2018

Triple Negative Breast Cancer – avoid Asparagine

Dr. Weeks’ Comment:  So what are the asparagine rich foods? Dairy Eggs Meat and especially  asparagus from which it was synthesized in 1932.  Asparagine and its partner aspartic acid have calming effects on the neurological system but this new cancer research is intriguing.

Foods low in asparagine are fruits and vegetables.

Remember that asparagine is a nonessential amino acid. That means you make your own asparagine as it is manufactured from other amino acids in the liver. It can come from diet, but it does not have to be. Still avoiding foods rich in asparagine seems prudent.

 

Asparagine bioavailability governs metastasis in a model of breast cancer

  • Nature
  • doi:10.1038/nature25465
Published online:

Abstract

Using a functional model of breast cancer heterogeneity, we previously showed that clonal sub-populations proficient at generating circulating tumour cells were not all equally capable of forming metastases at secondary sites1. A combination of differential expression and focused in vitro and in vivo RNA interference screens revealed candidate drivers of metastasis that discriminated metastatic clones. Among these, asparagine synthetase expression in a patient’s primary tumour was most strongly correlated with later metastatic relapse. Here we show that asparagine bioavailability strongly influences metastatic potential. Limiting asparagine by knockdown of asparagine synthetase, treatment with L-asparaginase, or dietary asparagine restriction reduces metastasis without affecting growth of the primary tumour, whereas increased dietary asparagine or enforced asparagine synthetase expression promotes metastatic progression. Altering asparagine availability in vitro strongly influences invasive potential, which is correlated with an effect on proteins that promote the epithelial-to-mesenchymal transition. This provides at least one potential mechanism for how the bioavailability of a single amino acid could regulate metastatic progression.

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Dr. Weeks’ Comment:  So what are the asparagine rich foods? Dairy Eggs Meat and especially  asparagus from which it was synthesized in 1932.  Asparagine and its partner aspartic acid have calming effects on the neurological system but this new cancer research is intriguing. Foods low in asparagine are fruits and vegetables. Remember that asparagine is…
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