Foods that kill cancer STEM cells

Dr. Weeks’ Comment: Cancer STEM cells are your target – NOT the cancer TUMOR cells which chemotherapy and radiation therapy target.

 

 2015 Nov;35(11):5773-88.

Natural Products That Target Cancer Stem Cells.

Abstract

The cancer stem cell model suggests that tumor initiation is governed by a small subset of distinct cells with stem-like character termed cancer stem cells (CSCs). CSCs possess properties of self-renewal and intrinsic survival mechanisms that contribute to resistance of tumors to most chemotherapeutic drugs. The failure to eradicate CSCs during the course of therapy is postulated to be the driving force for tumor recurrence and metastasis. Recent studies have focused on understanding the unique phenotypic properties of CSCs from various tumor types, as well as the signaling pathways that underlie self-renewal and drug resistance. Natural products (NPs) such as those derived from botanicals and food sources may modulate vital signaling pathways involved in the maintenance of CSC phenotype. The Wingless/Integrated (WNT), Hedgehog, Notch and PI3K/AKT/mTOR pathways have all been associated with quiescence and self-renewal of CSCs, as well as execution of CSC function including differentiation, multidrug resistance and metastasis. Recent studies evaluating NPs against CSC support the epidemiological evidence linking plant-based diets with reduced malignancy rates. This review covers the key aspects of NPs as modulators of CSC fate.

Here listed below are the list of the cancer STEM cell killing agents with some of their commonly recognizable dietary sources:

  1. Epigallocatechin-3-gallate (EGCG) – Green Tea

  2. 6-Gingerol – Ginger

  3. β-Carotene – Carrot, Leafy Greens

  4. Baicalein – Chinese Skullcap

  5. Curcumin – Turmeric

  6. Cyclopamine – Corn Lilly [we do not suggest consuming this plant; this simply illustrates natural components exist that kill cancer stem cells]

  7. Delphinidin – Blueberry, raspberrry

  8. Flavonoids (Genistein) – Soy, red clover, coffee

  9. Gossypol – Cottonseed [we do not suggest consuming this plant; this simply illustrates natural components exist that kill cancer stem cells]

  10. Guggulsterone – Commiphora (myrrh tree)

  11. Isothiocyanates – Cruciferous vegetables

  12. Linalool – Mint

  13. Lycopene – Grapefruit, tomato

  14. Parthenolide – Feverfew

  15. Perylill alcohol – Mint, cherry, lavender

  16. Piperine – Black pepper

  17. Placycodon saponin – Playycodon grandifloruim

  18. Psoralidin – Psoralea corylilyfolia

  19. Quercetin – Capers, onion

  20. Resveratrol – Grapes, plums, berries

  21. Salinomycin – Streptomyces albus

  22. Silibinin – Milk Thistle

  23. Ursolic acid – Thyme, basil, oregano

  24. Vitamin D3 – Fish, egg yolk, beef, cod liver oil

  25. Withaferin A – Withania somnifera (ashwaganda)

Share This Post

Dr. Weeks’ Comment: Cancer STEM cells are your target – NOT the cancer TUMOR cells which chemotherapy and radiation therapy target.   Anticancer Res. 2015 Nov;35(11):5773-88. Natural Products That Target Cancer Stem Cells. Moselhy J1, Srinivasan S1, Ankem MK1, Damodaran C2. Abstract The cancer stem cell model suggests that tumor initiation is governed by a small subset of distinct…
&source=WeeksMD">