Multiple Sclerosis and Black Cumin Seed

Dr. Weeks’ Comment: Clinically speaking, we see great improvement in MS symptoms when people drink SOUL, a three seed drink made from the three most powerful anti-inflammatory seeds:  black cumin, raspberry and Chardonnay Grape seeds.   Also the myelin sheath, where the MS lesions short-circuit neurological transmission, is made of primarily omega-6 and not omega-3 fatty acids so … STOP all fish and krill oil and use omega-6 seed oil (not the hydrogenated rancid toxic vegetable oils which are responsible for the misconception that omega 6 oils are inflammatory – not seed oils, only the canola-like inflammatory vegetable oils) to repair your myelin sheath.

Health Principle: Good oil in kicks bad oils out.  Every 4000 miles or so you CHANGE your OIL.  Not a teaspoon at a time but all bad oil out and it is replaced by good oil so your car engine runs well and serves you. How about your body?  is it serving you well enough? If not then it is time to CHANGE your OIL and give your myelin sheath the fatty acids it needs to repair itself.

MS is a disease of the nervous system and the nervous system is a fatty acid (oil) system where omega-6 receptors outnumber omega-3 receptors 100:1.   It is time to Eat the Seeds – flood your body with anti-inflammatory omega-6 seed oilsand your neurological system will run more smoothly.

HERE is the science demonstrating the benefit of black cumin seed with MS and with the experimental animal model of MS which is autoimmune encephalitis. 

Phytother Res.2016 Aug;30(8):1219-29. doi: 10.1002/ptr.5634. Epub 2016 May 11.

A review of Neuropharmacology Effects of Nigella sativa and Its Main Component, Thymoquinone.

Javidi S1, Razavi BM2, Hosseinzadeh H3.

Abstract

Neuropharmacology is the scientific study of drug effect on nervous system. In the last few years, different natural plants and their active constituents have been used in neurological therapy. The availability, lower price, and less toxic effects of herbal medicines compared with synthetic agents make them as simple and excellent choice in the treatment of nervous diseases. Nigella sativa, which belongs to the botanical family of Ranunculaceae, is a widely used medicinal plant all over the world. In traditional and modern medicines several beneficial properties have been attributed to N. sativa and its main component, thymoquinone (TQ). In this review, various studies in scientific databases regarding the neuropharmacological aspects of N. sativa and TQ have been introduced. Results of these studies showed that N. sativa and TQ have several properties including anticonvulsant, antidepressant, anxiolytic, anti-ischemic, analgesic, antipsychotic, and memory enhancer. Furthermore, its protective effects against neurodegenerative diseases such as Alzheimer, Parkinson and multiple sclerosis have been discussed. Although there are many studies indicating the beneficial actions of this plant in nervous system, the number of research projects relating to the human reports is rare.

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Int J Clin Exp Pathol.2015 Jun 1;8(6):6269-86. eCollection 2015.

Nigella sativa amliorates inflammation and demyelination in the experimental autoimmune encephalomyelitis-induced Wistar rats.

Noor NA1, Fahmy HM2, Mohammed FF3, Elsayed AA2, Radwan NM1.

Abstract

Multiple sclerosis (MS) is the major, immune-mediated, demyelinating neurodegenerative disease of the central nervous system (CNS). Experimental autoimmune encephalomyelitis (EAE) is a well-established animal model of MS. The aim of the present study was to investigate the protective and ameliorative effects of N. sativa seeds (2.8 g/kg body weight) in EAE-induced Wistar rats. EAE-induced rats were divided into: 1- EAE-induced rats (“EAE” group). 2- “N. sativa + EAE” group received daily oral administration of N. sativa 2 weeks prior EAE induction until the end of the experiment. 3- “EAE + N. sativa” group received daily oral administration of N. sativa after the appearance of first clinical signs until the end of the experiment. All animals were decapitated at the 28th day post EAE-induction. EAE was investigated using histopathological, immunohistochemical and ultrastructural examinations in addition to determination of some oxidative stress parameters in the cerebellum and medulla. N. sativa suppressed inflammation observed in EAE-induced rats. In addition, N. sativa enhanced remyelination in the cerebellum. Moreover, N. sativa reduced the expression of transforming growth factor beta 1 (TGF β1). N. sativa seeds could provide a promising agent effective in both the protection and treatment of EAE.

Free PMC Article

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Biomed Sci Instrum.2009;45:274-9.

Amelioration of chronic relapsing experimental autoimmune encephalomyelitis (cr-eae) using thymoquinone – biomed 2009.

Mohamed A1, Waris HMRamadan HQuereshi MKalra J.

Abstract

Axonal damage, demylination and inflammation of the central nervous system are the major pathological features of the human multiple sclerosis (MS). MS is thought to be due to abnormal T cell mediated immune response. Oxidative stress plays an important role in the advancement of MS. The management of oxidative stress by outlining central role of reduced glutathione. In our experiment we used Experimental autoimmune encephalomyelitis (EAE) animal model that mimic human MS and tested the effect of Thymoquinone (TQ), an oil constituent of Nigella Sativa also known as black seed. Thirty female mice of strain C57BL/6J and aged between 6 to 12 weeks were placed into 3 groups of 10 and were given Myelin Oligodendrocyte Glycoprotein (MOG) subcutaneously (SC) to induce EAE. Group A was the control group. Group B received MOG (SC) and TQ intraperiotoneally (IP) from day 1 till day 50. Group C received MOG (SC) and TQ (IP) on the appearance of first sign and symptoms of chronic relapsing EAE (CR-EAE). All Mice were examined daily for behavioral deficits and all euthanized and sacrificed on day 50. Preliminary result showed that TQ due to its antioxidant effect is almost 90% preventive and 50% curative in CR-EAE. This result could assist further studies on the mechanism of action of TQ in CR-EAE and explore the possibility of treating the human chronic relapsing multiple sclerosis phase.

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Cell Mol Biol (Noisy-le-grand).2005 Sep 5;51(3):337-42.

The effect of Nigella sativa oil against experimental allergic encephalomyelitis via nitric oxide and other oxidative stress parameters.

Ozugurlu F1, Sahin SIdiz NAkyol OIlhan AYigitoglu RIsik B.

Abstract

Reactive oxygen species (ROS) including nitric oxide (NO) are thought to be involved in inflammatory processes, exacerbating inflammation and tissue damage in multiple sclerosis (MS). The oil extracts of Nigella sativa (N. sativa) has been known as an antioxidant and antiinflammatory agent. The aim of the present study was to investigate the hypothesis that N. sativa components provide protection against oxidative stress induced by experimental autoimmune encephalomyelitis (EAE) in rats. For this purpose, EAE was induced in rats by using guinea pig myelin basic protein (MBP) in Freud’s adjuvant with addition of heat-killed M. Tuberculosis H37Ra to test this hypothesis. In study groups, N. sativa was given by oral gavage to the rats. Treatment of the rats with N. sativa inhibited ROS production induced by EAE showing diminished levels of MDA of both brain and medulla spinalis tissues. Although there was a significant decrease in brain NO level, there was an increase in medulla spinalis NO level after EAE induction in rats. N. sativa regulated tissue NO levels in some extend when applied together with EAE. When N. sativa was given alone to the rats, no changes were shown in brain, medulla spinalis, and serum oxidant/antioxidant parameters. In conclusion, N sativa may protect brain and medulla spinalis tissues against oxidative stress induced by EAE. In addition, N. sativa display its antioxidant and regulatory effects via inflammatory cells rather than the host tissue (brain and medulla spinalis) for EAE in rats.

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Adv Pharm Bull.2018 Nov;8(4):575-590. doi: 10.15171/apb.2018.066. Epub 2018 Nov 29.

A Review of Herbal Therapy in Multiple Sclerosis.

Mojaverrostami S1, Bojnordi MN2,3, Ghasemi-Kasman M4, Ebrahimzadeh MA5, Hamidabadi HG2,6.

Young Researchers and Elite Club, Behshahr Branch, Islamic Azad University, Behshahr, Iran. et al

Abstract

Multiple sclerosis is a complex autoimmune disorder which characterized by demyelination and axonal loss in the central nervous system (CNS). Several evidences indicate that some new drugs and stem cell therapy have opened a new horizon for multiple sclerosis treatment, but current therapies are partially effective or not safe in the long term. Recently, herbal therapies represent a promising therapeutic approach for multiple sclerosis disease. Here, we consider the potential benefits of some herbal compounds on different aspects of multiple sclerosis disease. The medicinal plants and their derivatives; Ginkgo biloba, Zingiber officinale, Curcuma longa, Hypericum perforatum, Valeriana officinalis, Vaccinium macrocarpon, Nigella sativa,Piper methysticum, Crocus sativus, Panax ginseng, Boswellia papyrifera, Vitis vinifera, Gastrodia elata, Camellia sinensis, Oenothera biennis, MS14 and Cannabis sativa have been informed to have several therapeutic effects in MS patients.

Free PMC Article

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… NOW THEY TRY AND PATENT IT AND MAKE IT A DRUG…

Pharmacognosy Res.2017 Jan-Mar;9(1):12-20. doi: 10.4103/0974-8490.199774.

The Influence of Pluronic F68 and F127 Nanocarrier on Physicochemical Properties, In vitroRelease, and Antiproliferative Activity of Thymoquinone Drug.

Shaarani S1, Hamid SS2, Mohd Kaus NH1.

Abstract

BACKGROUND:

This study reports on hydrophobic drug thymoquinone (TQ), an active compound found in the volatile oil of Nigella sativathat exhibits anticancer activities. Nanoformulation of this drug could potentially increase its bioavailability to specific target cells.

CONCLUSION:

This study suggests higher molecular weight Pluronic polymer micelles (F127) with hydrophilic-hydrophobic segments which could be used as a suitable candidate for sustainable delivery of TQ. However, comprehensive studies should be carried out to establish the suitability of Pluronic F127 as a carrier for other drugs with similar challenges as TQ.

SUMMARY:

There is a rising interest in integrating nanotechnology with medicine, creating a nanomedicine aiming for high efficiency and efficacy of disease diagnosis and treatment. In drug delivery, the term nanomedicine describes the nanometer-sized range (1-1000 nm) of a multi-component drug for disease treatments. As such, liposome-based nanoparticulate delivery vehicles have been approved by the Food and Drug Administration (FDA) for clinical applications. The main purpose of introducing nanoscale drug delivery is to improve the pharmacological and pharmacokinetic profiles of therapeutic molecules. Drug or therapeutic molecules can be either released through the cleavage of a covalent linkage between drug molecules and polymers (conjugation) or through the diffusion from a drug and polymer blended matrix (physical encapsulation). Polymers play an important role in the design of nanocarriers for therapeutic deliveries. In Asia, Nigella sativa seed oil has been used traditionally for its various medicinal benefits. One of its most potent compound which is thymoquinone has been intensively investigated for its anti-cancer effects in colorectal carcinoma, breast adenocarcinoma, osteosarcoma, ovarian carcinoma, myeloblastic leukemia, and pancreatic carcinoma. In addition, it is reported to show anti-inflammatory potential, antidiabetic, antihistaminic effects, as well as the ability to alleviate respiratory diseases, rheumatoid arthritis, multiple sclerosis, and Parkinson’s disease. This study aims to formulate and characterize different pluronic-based thymoquinone nanocarrier and investigate its effect against breast cancer cells 

Free PMC Article

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Dr. Weeks’ Comment: Clinically speaking, we see great improvement in MS symptoms when people drink SOUL, a three seed drink made from the three most powerful anti-inflammatory seeds:  black cumin, raspberry and Chardonnay Grape seeds.   Also the myelin sheath, where the MS lesions short-circuit neurological transmission, is made of primarily omega-6 and not omega-3 fatty acids so…
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