Dr. Weeks’ Comment: Black cumin seed is a potent ingredient in SOUL, the 3 seed drink made from seeds of anti-inflammatory plants. Here is some of the published research articles demonstrating the anti-cancer effects of this ancient yet potent healing plant.
Alshatwi AA.
Chin J Integr Med. 2014 Mar 2. [Epub ahead of print]
- PMID:
24584754
[PubMed – as supplied by publisher]
Cytotoxicity of nigella sativa seed oil and extract against human lung cancer cell line.
Al-Sheddi ES, Farshori NN, Al-Oqail MM, Musarrat J, Al-Khedhairy AA, Siddiqui MA.
Asian Pac J Cancer Prev. 2014;15(2):983-7.
Thymoquinone in the clinical treatment of cancer: Fact or fiction?
Abukhader MM.
Pharmacogn Rev. 2013 Jul;7(14):117-120. Review.
Baharetha HM, Nassar ZD, Aisha AF, Ahamed MB, Al-Suede FS, Abd Kadir MO, Ismail Z, Majid AM.
J Med Food. 2013 Dec;16(12):1121-30. doi: 10.1089/jmf.2012.2624.
- PMID:
24328702
[PubMed – in process]
Thymoquinone causes multiple effects, including cell death, on dividing plant cells.
Hassanien SE, Ramadan AM, Azeiz AZ, Mohammed RA, Hassan SM, Shokry AM, Atef A, Kamal KB, Rabah S, Sabir JS, Abuzinadah OA, El-Domyati FM, Martin GB, Bahieldin A.
C R Biol. 2013 Nov-Dec;336(11-12):546-56. doi: 10.1016/j.crvi.2013.10.007. Epub 2013 Nov 19.
Rajput S, Kumar BN, Dey KK, Pal I, Parekh A, Mandal M.
Life Sci. 2013 Nov 13;93(21):783-90. doi: 10.1016/j.lfs.2013.09.009. Epub 2013 Sep 15.
- PMID:
24044882
[PubMed – indexed for MEDLINE]
Racoma IO, Meisen WH, Wang QE, Kaur B, Wani AA.
PLoS One. 2013 Sep 9;8(9):e72882. doi: 10.1371/journal.pone.0072882. eCollection 2013.
Thymoquinone induces mitochondria-mediated apoptosis in acute lymphoblastic leukaemia in vitro.
Salim LZ, Mohan S, Othman R, Abdelwahab SI, Kamalidehghan B, Sheikh BY, Ibrahim MY.
Molecules. 2013 Sep 12;18(9):11219-40. doi: 10.3390/molecules180911219.
Cellular responses with thymoquinone treatment in human breast cancer cell line MCF-7.
Motaghed M, Al-Hassan FM, Hamid SS.
Pharmacognosy Res. 2013 Jul;5(3):200-6. doi: 10.4103/0974-8490.112428.
Looi CY, Moharram B, Paydar M, Wong YL, Leong KH, Mohamad K, Arya A, Wong WF, Mustafa MR.
BMC Complement Altern Med. 2013 Jul 10;13:166. doi: 10.1186/1472-6882-13-166.
Velho-Pereira R, Kumar A, Pandey BN, Mishra KP, Jagtap AG.
Indian J Pharm Sci. 2012 Sep;74(5):403-14. doi: 10.4103/0250-474X.108415.
Thymoquinone attenuates tumor growth in ApcMin mice by interference with Wnt-signaling.
Lang M, Borgmann M, Oberhuber G, Evstatiev R, Jimenez K, Dammann KW, Jambrich M, Khare V, Campregher C, Ristl R, Gasche C.
Mol Cancer. 2013 May 13;12(1):41. doi: 10.1186/1476-4598-12-41.
Thymoquinone suppresses metastasis of melanoma cells by inhibition of NLRP3 inflammasome.
Ahmad I, Muneer KM, Tamimi IA, Chang ME, Ata MO, Yusuf N.
Toxicol Appl Pharmacol. 2013 Jul 1;270(1):70-6. doi: 10.1016/j.taap.2013.03.027. Epub 2013 Apr 10.
- PMID:
23583630
[PubMed – indexed for MEDLINE]
Yusufi M, Banerjee S, Mohammad M, Khatal S, Venkateswara Swamy K, Khan EM, Aboukameel A, Sarkar FH, Padhye S.
Bioorg Med Chem Lett. 2013 May 15;23(10):3101-4. doi: 10.1016/j.bmcl.2013.03.003. Epub 2013 Mar 14.
- PMID:
23562242
[PubMed – indexed for MEDLINE]
Hasan TN, Shafi G, Syed NA, Alfawaz MA, Alsaif MA, Munshi A, Lei KY, Alshatwi AA.
Nat Prod Commun. 2013 Feb;8(2):213-6.
- PMID:
23513732
[PubMed – indexed for MEDLINE]
Mahmoud SS, Torchilin VP.
Cell Biochem Biophys. 2013 Jul;66(3):451-60. doi: 10.1007/s12013-012-9493-4.
- PMID:
23242945
[PubMed – indexed for MEDLINE]
Sutton KM, Doucette CD, Hoskin DW.
Biochem Biophys Res Commun. 2012 Sep 28;426(3):421-6. doi: 10.1016/j.bbrc.2012.08.111. Epub 2012 Aug 30.
- PMID:
22960073
[PubMed – indexed for MEDLINE]
Use of complementary and alternative medicine by patients with cancer in Saudi Arabia.
Jazieh AR, Al Sudairy R, Abulkhair O, Alaskar A, Al Safi F, Sheblaq N, Young S, Issa M, Tamim H.
J Altern Complement Med. 2012 Nov;18(11):1045-9. doi: 10.1089/acm.2011.0266. Epub 2012 Aug 20.
- PMID:
22906212
[PubMed – indexed for MEDLINE]
Abdel-Hamid NM, Abdel-Ghany MI, Nazmy MH, Amgad SW.
Environ Health Prev Med. 2013 Jan;18(1):49-56. doi: 10.1007/s12199-012-0292-8. Epub 2012 Jul 6.
Characterization of thymoquinone binding to human αâ‚-acid glycoprotein.
Lupidi G, Camaioni E, Khalifé H, Avenali L, Damiani E, Tanfani F, Scirè A.
J Pharm Sci. 2012 Jul;101(7):2564-73. doi: 10.1002/jps.23138. Epub 2012 Mar 29.
- PMID:
22467430
[PubMed – indexed for MEDLINE]
Samarakoon SR, Thabrew I, Galhena PB, Tennekoon KH.
BMC Complement Altern Med. 2012 Mar 29;12:25. doi: 10.1186/1472-6882-12-25.
Lei X, Lv X, Liu M, Yang Z, Ji M, Guo X, Dong W.
Biochem Biophys Res Commun. 2012 Jan 13;417(2):864-8. doi: 10.1016/j.bbrc.2011.12.063. Epub 2011 Dec 20.
- PMID:
22206670
[PubMed – indexed for MEDLINE]
Anticancer activity of Nigella sativa (black seed) – a review.
Randhawa MA, Alghamdi MS.
Am J Chin Med. 2011;39(6):1075-91. Review.
- PMID:
22083982
[PubMed – indexed for MEDLINE]
Salem ML, Alenzi FQ, Attia WY.
Br J Biomed Sci. 2011;68(3):131-7.
- PMID:
21950205
[PubMed – indexed for MEDLINE]
Alhosin M, Ibrahim A, Boukhari A, Sharif T, Gies JP, Auger C, Schini-Kerth VB.
Invest New Drugs. 2012 Oct;30(5):1813-9. doi: 10.1007/s10637-011-9734-1. Epub 2011 Sep 1.
- PMID:
21881916
[PubMed – indexed for MEDLINE]
Sorenson BS, Banton KL, Augustin LB, Leonard AS, Saltzman DA.
Onco Targets Ther. 2011;4:59-69. doi: 10.2147/OTT.S17081. Epub 2011 May 30.
Velho-Pereira R, Kumar A, Pandey BN, Jagtap AG, Mishra KP.
Cell Biol Int. 2011 Oct;35(10):1025-9. doi: 10.1042/CBI20100701.
- PMID:
21557727
[PubMed – indexed for MEDLINE]
Anticancer activities of Nigella sativa (black cumin).
Khan MA, Chen HC, Tania M, Zhang DZ.
Afr J Tradit Complement Altern Med. 2011;8(5 Suppl):226-32. doi: 10.4314/ajtcam.v8i5S.10. Epub 2011 Jul 3. Review.
The protective effect of thymoquinone against sepsis syndrome morbidity and mortality in mice.
Alkharfy KM, Al-Daghri NM, Al-Attas OS, Alokail MS.
Int Immunopharmacol. 2011 Feb;11(2):250-4. doi: 10.1016/j.intimp.2010.11.032. Epub 2010 Dec 9.
- PMID:
21145996
[PubMed – indexed for MEDLINE]
Arafa el-SA, Zhu Q, Shah ZI, Wani G, Barakat BM, Racoma I, El-Mahdy MA, Wani AA.
Mutat Res. 2011 Jan 10;706(1-2):28-35. doi: 10.1016/j.mrfmmm.2010.10.007. Epub 2010 Oct 30.
Review on molecular and therapeutic potential of thymoquinone in cancer.
Banerjee S, Padhye S, Azmi A, Wang Z, Philip PA, Kucuk O, Sarkar FH, Mohammad RM.
Nutr Cancer. 2010;62(7):938-46. doi: 10.1080/01635581.2010.509832. Review.
- PMID:
20924969
[PubMed – indexed for MEDLINE]
Abusnina A, Alhosin M, Keravis T, Muller CD, Fuhrmann G, Bronner C, Lugnier C.
Cell Signal. 2011 Jan;23(1):152-60. doi: 10.1016/j.cellsig.2010.08.015. Epub 2010 Aug 31.
- PMID:
20807569
[PubMed – indexed for MEDLINE]
Salim EI.
Oncol Lett. 2010 Sep;1(5):913-924. Epub 2010 Sep 1.
Nigella sativa: reduces the risk of various maladies.
Butt MS, Sultan MT.
Crit Rev Food Sci Nutr. 2010 Aug;50(7):654-65. doi: 10.1080/10408390902768797. Review.
- PMID:
20694927
[PubMed – indexed for MEDLINE]
Tangyuenyongwatana P, Gritsanapan W.
Pharm Biol. 2010 May;48(5):584-8. doi: 10.3109/13880200903214223.
- PMID:
20645803
[PubMed – indexed for MEDLINE]
Salem EM, Yar T, Bamosa AO, Al-Quorain A, Yasawy MI, Alsulaiman RM, Randhawa MA.
Saudi J Gastroenterol. 2010 Jul-Sep;16(3):207-14. doi: 10.4103/1319-3767.65201.
Majdalawieh AF, Hmaidan R, Carr RI.
J Ethnopharmacol. 2010 Sep 15;131(2):268-75. doi: 10.1016/j.jep.2010.06.030. Epub 2010 Jun 30.
- PMID:
20600757
[PubMed – indexed for MEDLINE]
Thymoquinone and cisplatin as a therapeutic combination in lung cancer: In vitro and in vivo.
Jafri SH, Glass J, Shi R, Zhang S, Prince M, Kleiner-Hancock H.
J Exp Clin Cancer Res. 2010 Jul 1;29:87. doi: 10.1186/1756-9966-29-87.
Koka PS, Mondal D, Schultz M, Abdel-Mageed AB, Agrawal KC.
Exp Biol Med (Maywood). 2010 Jun;235(6):751-60. doi: 10.1258/ebm.2010.009369.
- PMID:
20511679
[PubMed – indexed for MEDLINE]
Torres MP, Ponnusamy MP, Chakraborty S, Smith LM, Das S, Arafat HA, Batra SK.
Mol Cancer Ther. 2010 May;9(5):1419-31. doi: 10.1158/1535-7163.MCT-10-0075. Epub 2010 Apr 27.
Structure-activity studies on therapeutic potential of Thymoquinone analogs in pancreatic cancer.
Banerjee S, Azmi AS, Padhye S, Singh MW, Baruah JB, Philip PA, Sarkar FH, Mohammad RM.
Pharm Res. 2010 Jun;27(6):1146-58. doi: 10.1007/s11095-010-0145-3. Epub 2010 Apr 27.
Effenberger K, Breyer S, Schobert R.
Chem Biodivers. 2010 Jan;7(1):129-39. doi: 10.1002/cbdv.200900328.
- PMID:
20087986
[PubMed – indexed for MEDLINE]
Induction of apoptosis in HeLa cells by chloroform fraction of seed extracts of Nigella sativa.
Shafi G, Munshi A, Hasan TN, Alshatwi AA, Jyothy A, Lei DK.
Cancer Cell Int. 2009 Nov 27;9:29. doi: 10.1186/1475-2867-9-29.
Chehl N, Chipitsyna G, Gong Q, Yeo CJ, Arafat HA.
HPB (Oxford). 2009 Aug;11(5):373-81. doi: 10.1111/j.1477-2574.2009.00059.x.
Al-Ali A, Alkhawajah AA, Randhawa MA, Shaikh NA.
J Ayub Med Coll Abbottabad. 2008 Apr-Jun;20(2):25-7.
- PMID:
19385451
[PubMed – indexed for MEDLINE]
Effects of thymoquinone-fatty acid conjugates on cancer cells.
Breyer S, Effenberger K, Schobert R.
ChemMedChem. 2009 May;4(5):761-8. doi: 10.1002/cmdc.200800430.
- PMID:
19322799
[PubMed – indexed for MEDLINE]
Effects of thymoquinone and selenium on the proliferation of mg 63 cells in tissue culture.
Barron J, Benghuzzi H, Tucci M.
Biomed Sci Instrum. 2008;44:434-40.
- PMID:
19141954
[PubMed – in process]
Padhye S, Banerjee S, Ahmad A, Mohammad R, Sarkar FH.
Cancer Ther. 2008;6(b):495-510.
Plant crude extracts could be the solution: extracts showing in vivo antitumorigenic activity.
Amara AA, El-Masry MH, Bogdady HH.
Pak J Pharm Sci. 2008 Apr;21(2):159-71.
- PMID:
18390447
[PubMed – indexed for MEDLINE]
Anti-tumor properties of blackseed (Nigella sativa L.) extracts.
Ait Mbarek L, Ait Mouse H, Elabbadi N, Bensalah M, Gamouh A, Aboufatima R, Benharref A, Chait A, Kamal M, Dalal A, Zyad A.
Braz J Med Biol Res. 2007 Jun;40(6):839-47.
Norwood AA, Tucci M, Benghuzzi H.
Biomed Sci Instrum. 2007;43:272-7.
- PMID:
17487093
[PubMed – indexed for MEDLINE]
Effect of spices on lipid metabolism in 1,2-dimethylhydrazine-induced rat colon carcinogenesis.
Nalini N, Manju V, Menon VP.
J Med Food. 2006 Summer;9(2):237-45.
- PMID:
16822210
[PubMed – indexed for MEDLINE]
Farah IO.
Int J Environ Res Public Health. 2005 Dec;2(3-4):411-9.
Norwood AA, Tan M, May M, Tucci M, Benghuzzi H.
Biomed Sci Instrum. 2006;42:350-6.
- PMID:
16817633
[PubMed – indexed for MEDLINE]
Iddamaldeniya SS, Thabrew MI, Wickramasinghe SM, Ratnatunge N, Thammitiyagodage MG.
J Carcinog. 2006 May 9;5:11.
El-Obeid A, Al-Harbi S, Al-Jomah N, Hassib A.
Phytomedicine. 2006 May;13(5):324-33. Epub 2005 Sep 19.
- PMID:
16635740
[PubMed – indexed for MEDLINE]
Thabrew MI, Mitry RR, Morsy MA, Hughes RD.
Life Sci. 2005 Aug 5;77(12):1319-30.
- PMID:
15916774
[PubMed – indexed for MEDLINE]
The effects of isolated antioxidants from black seed on the cellular metabolism of A549 cells.
Farah N, Benghuzzi H, Tucci M, Cason Z.
Biomed Sci Instrum. 2005;41:211-6.
- PMID:
15850107
[PubMed – indexed for MEDLINE]
Gali-Muhtasib H, Diab-Assaf M, Boltze C, Al-Hmaira J, Hartig R, Roessner A, Schneider-Stock R.
Int J Oncol. 2004 Oct;25(4):857-66.
- PMID:
15375533
[PubMed – indexed for MEDLINE]
Immunosuppressive and cytotoxic properties of Nigella sativa.
Islam SN, Begum P, Ahsan T, Huque S, Ahsan M.
Phytother Res. 2004 May;18(5):395-8.
- PMID:
15174000
[PubMed – indexed for MEDLINE]
Iddamaldeniya SS, Wickramasinghe N, Thabrew I, Ratnatunge N, Thammitiyagodage MG.
J Carcinog. 2003 Oct 18;2(1):6.
Salim EI, Fukushima S.
Nutr Cancer. 2003;45(2):195-202.
- PMID:
12881014
[PubMed – indexed for MEDLINE]
The role of black seed in the proliferation and biochemical marker levels of Hep-2 cells.
Hansen JT, Benghuzzi H, Tucci M, Cason Z.
Biomed Sci Instrum. 2003;39:371-6.
- PMID:
12724922
[PubMed – indexed for MEDLINE]
Delayed apoptosis upon the treatment of Hep-2 cells with black seed.
Corder C, Benghuzzi H, Tucci M, Cason Z.
Biomed Sci Instrum. 2003;39:365-70.
- PMID:
12724921
[PubMed – indexed for MEDLINE]
Farah IO, Begum RA.
Biomed Sci Instrum. 2003;39:359-64.
- PMID:
12724920
[PubMed – indexed for MEDLINE]
Swamy SM, Huat BT.
Mol Cell Biochem. 2003 Mar;245(1-2):127-39.
- PMID:
12708752
[PubMed – indexed for MEDLINE]
Inhibitory effects of thymoquinone against 20-methylcholanthrene-induced fibrosarcoma tumorigenesis.
Badary OA, Gamal El-Din AM.
Cancer Detect Prev. 2001;25(4):362-8.
- PMID:
11531013
[PubMed – indexed for MEDLINE]
Cytotoxic and immunopotentiating effects of ethanolic extract of Nigella sativa L. seeds.
Swamy SM, Tan BK.
J Ethnopharmacol. 2000 Apr;70(1):1-7.
- PMID:
10720783
[PubMed – indexed for MEDLINE]
Inhibition of benzo(a)pyrene-induced forestomach carcinogenesis in mice by thymoquinone.
Badary OA, Al-Shabanah OA, Nagi MN, Al-Rikabi AC, Elmazar MM.
Eur J Cancer Prev. 1999 Oct;8(5):435-40.
- PMID:
10548399
[PubMed – indexed for MEDLINE]
Worthen DR, Ghosheh OA, Crooks PA.
Anticancer Res. 1998 May-Jun;18(3A):1527-32.
- PMID:
9673365
[PubMed – indexed for MEDLINE]
Antitumour principles from Nigella sativa seeds.
Salomi NJ, Nair SC, Jayawardhanan KK, Varghese CD, Panikkar KR.
Cancer Lett. 1992 Mar 31;63(1):41-6.
- PMID:
1555206
[PubMed – indexed for MEDLINE]
Nair SC, Salomi MJ, Panikkar B, Panikkar KR.
J Ethnopharmacol. 1991 Jan;31(1):75-83.
- PMID:
2030595
[PubMed – indexed for MEDLINE]
Salomi MJ, Nair SC, Panikkar KR.
Nutr Cancer. 1991;16(1):67-72.
- PMID:
1923908
[PubMed – indexed for MEDLINE]