Dr. Weeks’ Comment: When we recall Hippocrates’s urging “Let food be your medicine and medicine be your food.” sometimes, it is hard to imagine that simply food will suffice. Many of my patients taking anti-inflammatory seed drinks worry that we are not doing enough to kill the cancer. We humans tend to have an irrational degree of confidence in synthetic patented drugs. But seeds are the answer. Seeds bioaccumulate nutrients and anti-cancer chemicals and are an essential foundational product to help the body reverse the cancer process. Now we focus on grape seeds and how they fight not just cancer TUMOR cells but the lethal cancer STEM cells. Get your whole, crushed, organic, non-GMO grape seeds here
“… OPCs from grape seed interfere with the ability of cancer stem cells to self-renew…”
Oligomeric proanthocyanidins (OPCs) target cancer stem-like cells and suppress tumor organoidformation in colorectal cancer.
Abstract
Proanthocyanidins are a heterogeneous group of flavan-3-ol or flavan-3,4-diol oligomers present in various fruits and vegetables. In particular, the smaller oligomeric subset of proanthocyanidins, termed the oligomeric proanthocyanidins (OPCs) appear to have potent anti-tumorigenic properties, but the underlying mechanisms for their effectiveness remain unclear. Herein, we utilized a series of in vitro, in vivo and patient-derived organoid approaches to systematically investigate the chemoprotective role of OPCs in colorectal cancer. OPCs exerted anti-tumorigenic effects through inhibition of cellular proliferation, and induced apoptosis and cell cycle arrest. Intriguingly, OPCs suppressed spheroid derived cancer stem-like cell formation and decreased the expression of intestinal cancer stem cell markers including LGR5, CD44 and CD133. Mechanistically, RNA-sequencing results confirmed that OPCs prominently interfered with developmental and self-renewal pathways and identified several self-renewal associated oncogenes targeted by OPCs. Furthermore, OPCs inhibited Hippo pathway through downregulation of its key transcriptional regulators, YAP and TAZ. Finally, we confirmed anti-tumorigenic effects of OPCs using multiple xenograft experiments and recapitulated its protective effects using patient-derived colorectaltumor organoids. Collectively, we have comprehensively assessed anti-tumorigenic properties of OPCs and our data throws light on previously unrecognized chemopreventive mechanisms of OPCs highlighting its therapeutic potential.
Study: French Grape Seed OPCs Suppress Tumor Formation in Cancer
Mar. 21, 2018, 09:01 AM
DALLAS, March 21, 2018 /PRNewswire/ — While the ability of grape seed extract’s oligomeric proanthocyanidins (OPC) to prevent tumors has been previously demonstrated, the underlying mechanisms have not been fully explored. A recent study, published in the journal Scientific Reports, has found several pathways by which a form of French grape seed OPC called VX1 prevents cancer, suppresses tumor formation, and inhibits tumor activity. [Toden S, Ravindranathan P, Gu J, Cardenas J, Yuchang M, Goel A. Oligomeric proanthocyanidins (OPCs) target cancer stem-like cells and suppress tumor organoid formation in colorectal cancer. Sci Rep. 2018 Feb 20;8(1):3335]
One of the most important findings was the way that OPCs from grape seed interfere with the ability of cancer stem cells to self-renew, and to re-emerge months or years after cancer treatment is completed.
“Cancer stem cells are able to hide, and are able to resist chemotherapy and other treatments,” said Ajay Goel, Ph.D., Professor and Director, Center of Gastroenterology, Translational Genomics and Oncology, Baylor Scott & White Research Institute, Baylor University Medical Center, Dallas, TX, the lead author and principal investigator of the study.
“That is why cancer can recur at later dates. The cancer stem cells come out of hiding and start to proliferate. Unfortunately, these new cancer cells are highly resistant to chemotherapy. Finding an effective compound that suppress cancer stem-cell formation in the first place is extremely promising for long-term cancer survival. In this study, we demonstrated that OPCs from French grape seed suppress the creation of cancer stem cells in colorectal cancer, which shows great therapeutic potential. That is in addition to its ability to activate anti-cancer pathways in the body to prevent cancer and to slow tumor growth,” stated Dr. Goel.
“This study was unique in that it not only showed the efficacy of OPCs in cancer cell lines, but also validated these findings in reducing colorectal cancer formation in an animal model. More importantly, the ability of OPCs to suppress cancer stem cell formation was confirmed using a new technique in which cells are harvested from a patient’s colon cancer tumor and developed into a 3D-tumor organoids in a laboratory setting. This is a unique approach that can be used for studying the effect of an anti-cancer compound in the patient’s own specific cancerous tumor. This validation provides a lot more confidence in these data for their validity in a human application,” continued Dr. Goel.
It is important to note that the form of French grape seed extract used in the study, VX1, has unique specifications, including standardization for only low molecular weight, high absorption OPCs and containing no tannins. Therefore, results may not apply to other forms of grape seed extract.
About Dr. Ajay Goel, Ph.D.
Dr. Ajay Goel, Ph.D., is a professor and the director of translational genomics and oncology, as well as the director of the Center for Gastrointestinal Research at the Baylor Scott & White Research Institute, Baylor University Medical Center in Dallas, Texas. One of the top scientists in the world, Dr. Goel investigates botanical interventions and has dedicated over 20 years to cancer research. Dr. Goel is also a leading author or contributor to more than 225 scientific articles published in peer-reviewed international journals and several book chapters, and the primary inventor on more than 15 international patents aimed at developing various biomarkers for the diagnosis, prognosis and prediction of gastrointestinal cancers. Dr. Goel is a member of the American Association for Cancer Research and the American Gastroenterology Association, and works privately with an organization in India to provide food, shelter, education and care for orphaned children.
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