Dr. Weeks’ Comment: Wiser words, as regarding health, may never have been spoken than; ‘Let food be thy medicine and let medicine be thy food” shared 2500 years ago by the ancient healer, Hippocrates. Yes, prescription medicines have an immediate and often powerful ability to change your symptomatology, but they’re working in the context of whatever other nutrients you put into your body in the first place. The Chinese have a saying that if the diet is bad the medicine is worthless and if the diet is good, the medicine is worthless. Increasingly were reverse engineering a lot of treatment protocols by discovering powerful therapeutic components of foods, like sulfurophane in broccoli, or luteolin in artichokes.

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Review

Heliyon. 2024 Feb 20;10(5):e26701.

doi: 10.1016/j.heliyon.2024.e26701. eCollection 2024 Mar 15.

Revisiting luteolin: An updated review on its anticancer potential

Abdur Rauf ¹, Polrat Wilairatana ², Payal B Joshi ³, Zubair Ahmad ¹, Ahmed Olatunde ⁴, Nabia Hafeez ⁵, Hassan A

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Luteolin, a Bioflavonoid Inhibits Colorectal Cancer through Modulation of Multiple Signaling Pathways: A Review

https://journal.waocp.org/article_29450.html

Abstract

Luteolin, 3’, 4’, 5,7-tetrahydroxyflavone, belongs to a group of naturally occurring compounds called flavonoids that are found widely in the plant kingdom. It possesses many beneficial properties including antioxidant, anti-inflammatory, anti-bacterial, anti-diabetic and anti-proliferative actions. Colorectal cancer (CRC) is a leading cause of cancer related deaths worldwide. Many signaling pathways are deregulated during the progression of colon cancer. In this review we aimed to analyze the protection offered by luteolin on colon cancer. During colon cancer genesis, luteolin known to reduce oxidative stress thereby protects the cell to undergo damage in vivo. Wnt/β-catenin signaling, deregulated during neoplastic development, is modified by luteolin. Hence, luteolin can be considered as a potential drug to treat CRC.

 

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The Inhibition of RXRα and RXRβ Receptors Provides Valuable Insights for Potential Prostate Cancer Treatment, in silico Molecular Docking and Molecular Dynamics Studies

Authors. Soykan Agar   ¹

Abstract

Introduction: Prostate cancer has emerged as a widespread health concern, with systemic inflammation believed to substantially contribute to its development and progression. The presence of systemic inflammatory responses has been established as an independent predictor of unfavorable long-term outcomes in prostate cancer patients. The goal of this study is to inhibit RXRα and RXRβ receptors, which are involved in prostate cancer, with Luteolin, Formononetin, and Kaempferol, with varying success. Methods: Retinoid X receptors (RXRs) hold crucial roles within the nuclear receptor (NR) superfamily, and compelling evidence from preclinical studies underscores the therapeutic potential of targeting RXRs for treating neurodegenerative and inflammatory conditions. Consequently, the ability to regulate and modulate RXRs using phytoestrogen ligands, Formononetin, Kaempferol, and Luteolin, assume paramount importance in treatment strategies. Results: The comprehensive in silico findings of this study vividly demonstrate the remarkable efficacy of Luteolin in inhibiting and modulating RXRα and RXRβ, while Formononetin emerges as a notably potent suppressor of RXRβ. Kaempferol, as the third compound, also exhibits commendable inhibitory attributes, although its impact is slightly less pronounced compared to the other two. Discussion: These findings highlight the notable binding and inhibition capabilities to RXRα and RXRβ, offering valuable insights for potential prostate cancer treatment avenues warranting further exploration through in vitro and in vivo analyses.

 

 

Foods rich in luteolin

Based on the search results, here are the foods that are rich in luteolin:

1. Parsley: A herb commonly used in cooking, parsley is a good source of luteolin, along with apigenin.
2. Artichoke: Artichokes contain luteolin and apigenin, which have been shown to protect cells against cancer and inhibit DNA oxidative damage.
3. Basil: Another popular herb, basil is a rich source of luteolin and apigenin.
4. Celery: Celery is particularly high in luteolin, making it an excellent addition to salads and other dishes.
5. Dandelion: The leaves of the dandelion plant are a good source of luteolin.
6. Onion: Onion leaves are also a good source of luteolin.
7. Olive leaves: Olive leaves contain luteolin, which may contribute to their potential health benefits.
8. Citrus fruits: While not as high as some of the above vegetables, citrus fruits like oranges and lemons do contain luteolin.
9. Cruciferous vegetables: Broccoli, in particular, is mentioned as a good source of luteolin, although the exact concentration may vary.
10. Green beans: Green beans are another vegetable that contains luteolin, making them a nutritious addition to meals.

Note: The exact concentration of luteolin in these foods may vary depending on factors like ripeness, preparation, and cooking methods. Additionally, some foods may have higher concentrations than others, but the overall amounts may still be relatively low compared to supplements or concentrated extracts.

See also

https://www.intake.health/post/37-luteolin-rich-foods-ranked-by-luteolin-density

See also

Luteolin : The Major Potential Benefits And Side Effects