Dr. Weeks Comment: Now that Bobby Kennedy Jr. has been instrumental in getting toxins out of our food and water (specifically fluoride and working on atrazine), let’s focus on what good items should be in the water. One hint is the molecular structure: two hydrogens to one oxygen. Everybody knows that water is good for you. In fact, our lives depend upon drinking good quality water. But what is water? It has two hydrogens for every one oxygen, H2O, and therefore perhaps we should learn more about how beneficial the two hydrogens are. Can you have H30 or maybe H4O? What you certainly can do to enhance your hydrogen consumption is to get a machine that bubbles hydrogen gas into a water bottle which achieves a therapeutic concentration of 2 ppm. This is where it gets tricky. Many machines are not as beneficial as they claim. We remain in a situation where buyer must beware. Let me share, not only a tutorial on hydrogen benefits, but also the specific device which we use in clinic. Lastly, we share a sampling of health challenges which are benefited by hydrogen. Just type in your search engine the term, “molecular hydrogen”and your illness. Below, we talk about the benefits of molecular hydrogen for cancer, heart disease, diabetes, dementia, Alzheimer’s as well as erectile dysfunction and endometrial inflammation.
Consider the myriad benefits of hydrogen inhaled and hydrogen in water:
http://www.molecularhydrogenfoundation.org
Google search “molecular hydrogen and heart disease (or any illness).
and
https://pmc.ncbi.nlm.nih.gov/articles/PMC10239052/
Hydrogen: inhalation versus hydrogenated water.
In a 16 ounce water bottle which is fully saturated with hydrogen, you get 0.8 mg of hydrogen.
If you breathe hydrogen for just 15 minutes of inhalation on the HH600, you get 800 mg of hydrogen, which is a thousandfold more bio-available hydrogen compared to drinking hydrogenated water. Also, hydrogen inhalation offers an immediate therapeutic benefit over days/weeks instead of manifesting after many months with Hydrogen water. Using therapeutic earmuffs, hydrogen gas can be delivered through the tympanic membrane of the ears into the brain and using the therapeutic eye goggles, hydrogen gas can be perfused into the eyes for visual improvement.
At the Weeks’ Clinic, we use Hydroheal 600 with a nasal cannula and also its water hydrogenating wand.
Let us know if you wish for a discounted price from HydroHeal – study here: https://www.hydroheal.com/pages/learn
CANCER
Asian Pac J Cancer Prev. 2023;24(1):37–47. doi: 10.31557/APJCP.2023.24.1.37
A Systematic Review of Molecular Hydrogen Therapy in Cancer Management
Muhammad Nooraiman Zufayri Mohd Noor 1, Adlin Sofea Alauddin 1, Yin How Wong 2, Chung Yeng Looi 3, Eng Hwa Wong 2, Priya Madhavan 2, Chai Hong Yeong 2,*
Abstract
Background:
Cancer remains a challenging target to cure, with present therapeutic methods unable to exhibit restorative outcomes without causing severe negative effects. Molecular hydrogen (H2) has been reported to be a promising adjunctive therapy for cancer treatment, having the capability to induce anti-proliferative, anti-oxidative, pro-apoptotic and anti-tumoural effects. This review summarises the findings from various articles on the mechanism, treatment outcomes, and overall effectiveness of H2 therapy on cancer management.
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MOLECULAR HYDROGEN as a Novel Antitumor Agent: Possible Mechanisms Underlying Gene Expression
Int. J. Mol. Sci. 2021, 22(16), 8724; https://doi.org/10.3390/ijms22168724
Department of Research and Development, MiZ Company Limited, 2-19-15 Ofuna, Kamakura 247-0056, Kanagawa, Japan
ABSTRACT
While many antitumor drugs have yielded unsatisfactory therapeutic results, drugs are one of the most prevalent therapeutic measures for the treatment of cancer. The development of cancer largely results from mutations in nuclear DNA, as well as from those in mitochondrial DNA (mtDNA). Molecular hydrogen (H2), an inert molecule, can scavenge hydroxyl radicals (·OH), which are known to be the strongest oxidizing reactive oxygen species (ROS) in the body that causes these DNA mutations. It has been reported that H2 has no side effects, unlike conventional antitumor drugs, and that it is effective against many diseases caused by oxidative stress and chronic inflammation. Recently, there has been an increasing number of papers on the efficacy of H2 against cancer and its effects in mitigating the side effects of cancer treatment. In this review, we demonstrate the efficacy and safety of H2 as a novel antitumor agent and show that its mechanisms may not only involve the direct scavenging of ·OH, but also other indirect biological defense mechanisms via the regulation of gene expression.
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BioMed Research International Volume 2022, Issue 1 8024452
Molecular Hydrogen Inhibits Colorectal Cancer Growth via the AKT/SCD1 Signaling Pathway
Xiangyan Zhang, Geru Tao, Ya’nan Zhao, Sijie Xing, Jie Jiang, Boyan Liu, Shucun Qin
First published: 26 April 2022
https://doi.org/10.1155/2022/8024452Digital Object Identifier (DOI)
Abstract
Molecular hydrogen (H2) has been considered a potential therapeutic target in many cancers. Therefore, we sought to assess the potential effect of H2 on colorectal cancer (CRC) in this study. Methods. The effect of H2 on the proliferation and apoptosis of RKO, SW480, and HCT116 CRC cell lines was assayed by CCK-8, colony formation, and flow cytometry assays. The effect of H2 on tumor growth was observed in xenograft implantation models (inhalation of 67% hydrogen two hours per day). Western blot and immunohistochemistry analyses were performed to examine the expression of p-PI3K, PI3K, AKT, pAKT, and SCD1 in CRC cell lines and xenograft mouse models. The expression of SCD1 in 491 formalin-fixed, paraffin-embedded CRC specimens was investigated with immunochemistry. The relationship between SCD1 status and clinicopathological characteristics and outcomes was determined. Results. Hydrogen treatment suppressed the proliferation of CRC cell lines independent of apoptosis, and the cell lines showed different responses to different doses of H2. Hydrogen also elicited a potent antitumor effect to reduce CRC tumor volume and weight in vivo. Western blot and IHC staining demonstrated that H2 inhibits CRC cell proliferation by decreasing pAKT/SCD1 levels, and the inhibition of cell proliferation induced by H2 was reversed by the AKT activator SC79. IHC showed that SCD1 expression was significantly higher in CRC tissues than in normal epithelial tissues (70.3% vs. 29.7%, p = 0.02) and was correlated with a more advanced TNM stage (III vs. I + II; 75.9% vs. 66.3%, p = 0.02), lymph node metastasis (with vs. without; 75.9% vs. 66.3%, p = 0.02), and patients without a family history of CRC (78.7% vs. 62.1%, p = 0.047). Conclusion. This study demonstrates that high concentrations of H2 exert an inhibitory effect on CRC by inhibiting the pAKT/SCD1 pathway. Further studies are warranted for clinical evaluation of H2 as SCD1 inhibitor to target CRC.
HEART HEALTH
Cell Mol Life Sci. 2023 Jun 3;80(6):174. doi: 10.1007/s00018-023-04818-4
Hydrogen therapy as a potential therapeutic intervention in heart disease: from the past evidence to future application
Kwannapas Saengsin 1, Rekwan Sittiwangkul 1, Siriporn C Chattipakorn 2,3,4,5, Nipon Chattipakorn 2,3,5,✉
Abstract
Cardiovascular disease is the leading cause of mortality worldwide. Excessive oxidative stress and inflammation play an important role in the development and progression of cardiovascular disease. Molecular hydrogen, a small colorless and odorless molecule, is considered harmless in daily life when its concentration is below 4% at room temperature. Owing to the small size of the hydrogen molecule, it can easily penetrate the cell membrane and can be metabolized without residue. Molecular hydrogen can be administered through inhalation, the drinking of hydrogen-rich water, injection with hydrogen-rich-saline, and bathing of an organ in a preservative solution. The utilization of molecular hydrogen has shown many benefits and can be effective for a wide range of purposes, from prevention to the treatment of diseases. It has been demonstrated that molecular hydrogen exerts antioxidant, anti-inflammatory, and antiapoptotic effects, leading to cardioprotective benefits. Nevertheless, the exact intracellular mechanisms of its action are still unclear. In this review, evidence of the potential benefits of hydrogen molecules obtained from in vitro, in vivo, and clinical investigations are comprehensively summarized and discussed with a focus on the cardiovascular aspects. The potential mechanisms involved in the protective effects of molecular hydrogen are also presented. These findings suggest that molecular hydrogen could be used as a novel treatment in various cardiovascular pathologies, including ischemic–reperfusion injury, cardiac injury from radiation, atherosclerosis, chemotherapy-induced cardiotoxicity, and cardiac hypertrophy.
BRAIN HEALTH
Curr Neuropharmacol. 2017 Feb;15(2):324–331. doi: 10.2174/1570159X14666160607205417
Molecular Hydrogen as a Neuroprotective Agent
Masumi Iketani 1, Ikuroh Ohsawa 1,*
Abstract
Oxidative stress and neuroinflammation cause many neurological disorders. Recently, it has been reported that molecular hydrogen (H2) functions as an antioxidant and anti-inflammatory agent. The routes of H2 administration in animal model and human clinical studies are roughly classified into three types, inhalation of H2 gas, drinking H2-dissolved water, and injection of H2-dissolved saline. This review discusses some of the remarkable progress that has been made in the research of H2 use for neurological disorders, such as cerebrovascular diseases, neurodegenerative disorders, and neonatal brain disorders. Although most neurological disorders are currently incurable, these studies suggest the clinical potential of H2 administration for their prevention, treatment, and mitigation. Several of the potential effectors of H2 will also be discussed, including cell signaling molecules and hormones that are responsible for preventing oxidative stress and inflammation. Nevertheless, further investigation will be required to determine the direct target molecule of H2.
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Molecular Hydrogen: an Emerging Therapeutic Medical Gas for Brain Disorders
- Published: 26 December 2022
Abstract
Oxidative stress and neuroinflammation are the main physiopathological changes involved in the initiation and progression of various neurodegenerative disorders or brain injuries. Since the landmark finding reported in 2007 found that hydrogen reduced the levels of peroxynitrite anions and hydroxyl free radicals in ischemic stroke, molecular hydrogen’s antioxidative and anti-inflammatory effects have aroused widespread interest. Due to its excellent antioxidant and anti-inflammatory properties, hydrogen therapy via different routes of administration exhibits great therapeutic potential for a wide range of brain disorders, including Alzheimer’s disease, neonatal hypoxic-ischemic encephalopathy, depression, anxiety, traumatic brain injury, ischemic stroke, Parkinson’s disease, and multiple sclerosis. This paper reviews the routes for hydrogen administration, the effects of hydrogen on the previously mentioned brain disorders, and the primary mechanism underlying hydrogen’s neuroprotection. Finally, we discuss hydrogen therapy’s remaining issues and challenges in brain disorders. We conclude that understanding the exact molecular target, finding novel routes, and determining the optimal dosage for hydrogen administration is critical for future studies and applications.
BLOOD SUGAR HEALTH
Exp Ther Med. 2020 Apr 30;20(1):359–366. doi: 10.3892/etm.2020.8708
Molecular hydrogen improves type 2 diabetes through inhibiting oxidative stress
Yi Ming 1, Qi-Hang Ma 1, Xin-Li Han 2, Hong-Yan Li 1,✉
Abstract
The aim of the present study was to investigate the potential therapeutic effects of molecular hydrogen on type 2 diabetes mellitus (T2DM) in rats. Following maintenance on a high-fat diet for 4 weeks, a T2DM model was established using an injection of 30 mg/kg streptozotocin via the caudal vein into Sprague-Dawley rats. On day 0 and Day 80, the blood samples were obtained from each rat for the measurement of biochemical indicators including blood lipids, fasting blood glucose, hepatic glycogen, fasting serum insulin, insulin sensitivity index, insulin resistance index, serum superoxide dismutase (SOD) and serum malondialdehyde (MDA) using an automatic biochemical analyzer. The kidneys and pancreas tissues were harvested for HE staining and Western blot assay of toll-like receptor 4 (TLR4), myeloid differentiation primary response 88 (MyD88), phosphorylated (p)-p65, p65, p-IκB and IκB. The results showed that in rats with T2DM, molecular hydrogen treatment decreased fasting blood glucose levels, increased hepatic glycogen synthesis and improved insulin sensitivity. Treatment with molecular hydrogen also increased the production of SOD whilst decreasing the production of MDA. In addition, molecular hydrogen alleviated the pathological changes exhibited by pancreatic islets and kidney during T2DM. Mechanistically, molecular hydrogen decreased TLR4 and MyD88 expression levels whilst also decreasing p65 and NF-κB inhibitor phosphorylation. In conclusion, molecular hydrogen exerted therapeutic effects against T2DM by improving hyperglycemia and inhibiting oxidative stress through mechanisms that are associated with the TLR4/MyD88/NF-κB signaling pathway.
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Therapeutic Potential of Molecular Hydrogen in Metabolic Diseases from Bench to Bedside
https://www.mdpi.com/1424-8247/16/4/541 by Fei Xie Yifei Song
Abstract
Oxidative stress and chronic inflammation have been implicated in the pathophysiology of metabolic diseases, including diabetes mellitus (DM), metabolic syndrome (MS), fatty liver (FL), atherosclerosis (AS), and obesity. Molecular hydrogen (H2) has long been considered a physiologically inert gas. In the last two decades, accumulating evidence from pre-clinical and clinical studies has indicated that H2 may act as an antioxidant to exert therapeutic and preventive effects on various disorders, including metabolic diseases. However, the mechanisms underlying the action of H2 remain unclear. The purpose of this review was to (1) provide an overview of the current research on the potential effects of H2 on metabolic diseases; (2) discuss the possible mechanisms underlying these effects, including the canonical anti-oxidative, anti-inflammatory, and anti-apoptotic effects, as well as suppression of ER stress, activation of autophagy, improvement of mitochondrial function, regulation of gut microbiota, and other possible mechanisms. The potential target molecules of H2 will also be discussed. With more high-quality clinical trials and in-depth mechanism research, it is believed that H2 will eventually be applied to clinical practice in the future, to benefit more patients with metabolic disease.
ERECTILE DYSFUNCTION/ UTERINE INFLAMMATION
Oxid Med Cell Longev. 2021 Jan 16;2021:8844346. doi: 10.1155/2021/8844346
Hydrogen Gas: A Novel Type of Antioxidant in Modulating Sexual Organs Homeostasis
Yaxing Zhang 1, Haimei Liu 1, Jinwen Xu 1, Shuhui Zheng 2, Lequan Zhou 1,✉
Abstract
Sex is a science of cutting edge but bathed in mystery. Coitus or sexual intercourse, which is at the core of sexual activities, requires healthy and functioning vessels to supply the pelvic region, thus contributing to clitoris erection and vaginal lubrication in female and penile erection in male. It is well known that nitric oxide (NO) is the main gas mediator of penile and clitoris erection. In addition, the lightest and diffusible gas molecule hydrogen (H2) has been shown to improve erectile dysfunction (ED), testis injuries, sperm motility in male, preserve ovarian function, protect against uterine inflammation, preeclampsia, and breast cancer in female. Mechanistically, H2 has strong abilities to attenuate excessive oxidative stress by selectively reducing cytotoxic oxygen radicals, modulate immunity and inflammation, and inhibit injuries-induced cell death. Therefore, H2 is a novel bioactive gas molecule involved in modulating sexual organs homeostasis.
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Journal of Urology Investigative Urology 1 Jul 2013
Min Fan https://doi.org/10.1016/j.juro.2012.12.001
Results:
Oxidative stress is involved in the pathophysiological mechanism of erectile dysfunction. Maximum intracavernous pressure in diabetic rats decreased significantly compared to controls and increased significantly compared to untreated diabetic rats after hydrogen-rich saline treatment. Decreased nitric oxide synthase activity, nitrite and nitrate, and eNOS expression as well as increased 8-hydroxydeoxyguanosine and malondialdehyde were found in the diabetic group compared to controls. Hydrogen-rich saline improved nitric oxide synthase activity, and malondialdehyde, nitrite and nitrate, and 8-hydroxydeoxyguanosine levels in the diabetic rat corpus cavernosum. Decreased eNOS in diabetic rats was ameliorated by hydrogen-rich saline. Also, apoptosis in the diabetic rat corpus cavernosum was significantly enhanced compared with controls. Hydrogen-rich saline therapy may decrease apoptosis in cavernous tissues and it ameliorated erectile dysfunction in diabetic rats by inhibiting oxidative stress and apoptosis.
Conclusions:
Hydrogen-rich saline effectively improved erectile function in a streptozotocin induced diabetic rat model of erectile dysfunction.