Progesterone receptors and cancer

Dr. Weeks’ Comment:  When the pathologist determines your estrogen receptors are positive in cancer, then by all means stop taking estrogen agents and increase BioDim and other agents to lower your estrogen since estrogen is well- understood to be carcinogenic.   But when your progesterone receptors (PR) are determined to be positive, what then? What does the science instruct us to do?  Well, since progesterone is ANTI-CANCER the logical conclusion is that when the progesterone receptors are positive (receptive and functional and ready to serve) then give progesterone and allow progesterone to do what it does best: counter-balance the cancer causing effect of estrogen.   Progestins are another story – being as they are synthetic near-miss progesterone mimickers. So by all means avoid progestins (an ingredient in the lethal drug PremPro which was recalled). Progestins cause cancer.  Does your oncologist understand that progestins are NOT actually synthetic progesterone but rather synthetic near-miss knock-offs of progesterone?  If not, either share the following research with him or her or simply find a more informed doctor!

 

John Lee MD  (who published what he learned from Ray Peat ND)  is quite persuasive.

Read this     and      also read this.

 

Ray Peat offers these insights:

 

  • Progesterone Summaries – Progesterone  – Ray Peat

    raypeat.com/articles/articles/progesterone-summaries.shtml

     Progesterone Information | Progesterone Supplementation … increased susceptibility to cancer, and progesterone has been used to treat some types of cancer.
  • Preventing and treating cancer with progesterone. – Ray Peat

    raypeat.com/articles/articles/cancerprogesterone.shtml

     RayPeat.com … Preventing and treating cancer with progesterone. …… significantly increased at 1458.4+/-2119.7 attomoles/mg RNA (mean +/- SD) as compared …
  • RU486, cancer, estrogen, and progesterone. – Ray Peat

    raypeat.com/articles/articles/ru486.shtml

    To speak of progesterone as contributing to the development of cancer in that ….. Groshong SD, Owen GI, Grimison B, Schauer IE, Todd MC, Langan TA, …

     

     

    And HERE is the recent scientific articles to share with your doctor…. if he or she is interested!

Progesterone inhibits growth and induces apoptosis in breast cancer cells: inverse effects on Bcl-2 and p53

B Formby, TS Wiley – Annals of Clinical & Laboratory Science, 1998 – Assoc Clin Scientists
Abstract Progesterone inhibits the proliferation of normal breast epithelial cells in vivo, as
well as breast cancer cells in vitro. But the biologic mechanism of this inhibition remains to
be determined. We explored the possibility that an antiproliferative activity of progesterone 

[HTML] Progesterone induces apoptosis and up”regulation of p53 expression in human ovarian carcinoma cell lines

SZ Bu, DL Yin, XH Ren, LZ Jiang, ZJ Wu, QR Gao… – Cancer, 1997 – Wiley Online Library
BACKGROUND Progesterone (PROG) has been shown to reduce the risk of developing
ovarian carcinoma in postmenopausal women who have undergone estrogen and
progestogen replacement therapy, and it has been clinically used to treat some types of 

… and variant CD44 v7-v10 are downregulated and p53 is upregulated in breast cancer cells byprogesterone: inhibition of cell growth and induction of apoptosis

B Formby, TS Wiley – Molecular and cellular biochemistry, 1999 – Springer
Abstract Progesterone inhibits the proliferation of normal breast epithelial cells in vivo, as
well as breast cancer cells in vitro. But the biologic mechanism of this inhibition remains to
be determined. We explored the possibility that an antiproliferative activity of progesterone 

Progesterone-induced apoptosis in immortalized normal and malignant human ovarian surface epithelial cells involves enhanced expression of FasL

V Syed, SM Ho – Oncogene, 2003 – nature.com
Abstract Progesterone (P4) has been implicated as a protective factor for epithelial ovarian
cancers, yet little is known about its mechanism of action. We previously reported that
pregnancy-equivalent doses of P4 inhibited the growth of normal and malignant human 

NK cells expressing a progesterone receptor are susceptible to progesterone-induced apoptosis

L Arruvito, S Giulianelli, AC Flores… – The Journal of …, 2008 – Am Assoc Immnol
Abstract It has been proposed that progesterone (P4) induces the suppression of immune
responses, particularly during pregnancy. However, knowledge about the mechanisms
involved has remained largely elusive. We demonstrate herein that peripheral blood NK ( …

Progesterone induces Apoptosis in TRAIL”resistant ovarian cancer cells by circumventing c”FLIPL overexpression

V Syed, K Mukherjee… – Journal of cellular …, 2007 – Wiley Online Library
Abstract Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) holds great
potential as an anticancer drug, since it induces selective cell death in cancer cells but not in
normal ones. However, cancer cells often acquire resistance to TRAIL, which hinders its 

Progesterone induces apoptosis in malignant mesothelioma cells.

K Horita, N Inase, S Miyake, B Formby… – Anticancer …, 2000 – europepmc.org
Progesterone has been used in the treatment of patients with recurrent or metastatic
progesterone receptor-positive endometrial carcinoma and breast cancer. In vitro study
using a breast cancer cell line, T47D, demonstrated an increase in p53 gene expression 

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Dr. Weeks’ Comment:  When the pathologist determines your estrogen receptors are positive in cancer, then by all means stop taking estrogen agents and increase BioDim and other agents to lower your estrogen since estrogen is well- understood to be carcinogenic.   But when your progesterone receptors (PR) are determined to be positive, what then? What…
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