Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes.
It is recognized that a chronic low-grade inflammation and an activation of the immune system are involved in the pathogenesis of obesity-related insulin resistance and type 2 diabetes. Systemic inflammatory markers are risk factors for the development of type 2 diabetes and its macrovascular complications. Adipose tissue, liver, muscle and pancreas are themselves sites of inflammation in presence of obesity. An infiltration of macrophages and other immune cells is observed in these tissues associated with a cell population shift from an anti-inflammatory to a pro-inflammatory profile. These cells are crucial for the production of pro-inflammatory cytokines, which act in an autocrine and paracrine manner to interfere with insulin signaling in peripheral tissues or induce β-cell dysfunction and subsequent insulin deficiency. Particularly, the pro-inflammatory interleukin-1β is implicated in the pathogenesis of type 2 diabetes through the activation of the NLRP3 inflammasome. The objectives of this review are to expose recent data supporting the role of the immune system in the pathogenesis of insulin resistance and type 2 diabetes and to examine various mechanisms underlying this relationship. If type 2 diabetes is an inflammatory disease, anti-inflammatory therapies could have a place in prevention and treatment of type 2 diabetes.
- Recent advances in the relationship between obesity, inflammation, and insulin resistance.
Bastard JP, et al. Eur Cytokine Netw. 2006.
- [Low-grade systemic inflammation and the development of metabolic diseases: from the molecular evidence to the clinical practice].
León-Pedroza JI, et al. Cir Cir. 2015.
- The role of inflammation and macrophage accumulation in the development of obesity-induced type 2 diabetes mellitus and the possible therapeutic effects of long-chain n-3 PUFA.
Oliver E, et al. Proc Nutr Soc. 2010.
- Obesity, inflammation, and insulin resistance–a mini-review.
Zeyda M, et al. Gerontology. 2009.
- Relationship between inflammation, insulin resistance and type 2 diabetes: ’cause or effect’?
Greenfield JR, et al. Curr Diabetes Rev. 2006.