Br J Surg. 1988 Jul;75(7):679-81.
Clinical observations on the wound healing properties of honey.
University Department of Surgery, University Teaching Hospital,
Fifty-nine patients with wounds and ulcers most of which (80 per cent) had failed to heal with conventional treatment were treated with unprocessed honey. Fifty-eight cases showed remarkable improvement following topical application of honey. One case, later diagnosed as Buruli ulcer, failed to respond. Wounds that were sterile at the outset, remained sterile until healed, while infected wounds and ulcer became sterile within 1 week of topical application of honey. Honey debrided wounds rapidly, replacing sloughs with granulation tissue. It also promoted rapid epithelialization, and absorption of oedema from around the ulcer margins.
Br J Surg. 1991 Apr;78(4):497-8.
Topical application of honey in treatment of burns.
Department of Surgery, Dr V.M. Medical College,
A total of 104 cases of superficial burn injury were studied to assess the efficiency of honey as a dressing in comparison with silver sulfadiazine gauze dressing. In the 52 patients treated with honey, 91 per cent of wounds were rendered sterile within 7 days. In the 52 patients treated with silver sulfadiazine, 7 per cent showed control of infection within 7 days. Healthy granulation tissue was observed earlier in patients treated with honey (mean 7.4 versus 13.4 days). Of the wounds treated with honey 87 per cent healed within 15 days as against 10 per cent in the control group. Relief of pain, a lower incidence of hypertrophic scar and postburn contracture, low cost and easy availability make honey an ideal dressing in the treatment of burns.
Burns. 1994 Aug;20(4):331-3.
Honey-impregnated gauze versus amniotic membrane in the treatment of burns.
Department of Surgery, Dr V. M. Medical College, Solapur,
A prospective randomized clinical study to compare honey-impregnated gauze with amniotic membrane dressing in partial thickness burns was carried out. Sixty-four patients were studied. Forty of them were treated with honey-impregnated gauze and 24 were treated with amniotic membrane. The burns treated with honey healed earlier as compared to the amniotic membrane (mean 9.4 vs 17.5 days) (P < 0.001). Residual scars were noted in 8 per cent of patients treated with honey-impregnated gauze and in 16.6 per cent of cases treated with amniotic membrane (P < 0.001).
Burns. 1998 Mar;24(2):157-61.
A prospective randomised clinical and histological study of superficial burn wound healing with honey and silver sulfadiazine.
Department of Surgery, Dr Vaishampayan Memorial Medical College,
Histological and clinical studies of wound healing have been made on comparable fresh partial thickness burns with honey dressing or silver sulfadiazine (SSD) in two groups of 25 randomly allocated patients. Of the wounds treated with honey 84 per cent showed satisfactory epithelialization by the 7th day, and in 100 per cent of the patients by the 21st day. In wounds treated with silver sulfadiazine, epithelialization occurred by the 7th day in 72 per cent of the patients and in 84 per cent of patients by 21 days. Histological evidence of reparative activity was seen in 80 per cent of wounds treated with the honey dressing by the 7th day with minimal inflammation. Fifty two per cent of the silver sulfadiazine treated wounds showed reparative activity with inflammatory changes by the 7th day. Reparative activity reached 100 per cent by 21 days with the honey dressing and 84 per cent with SSD. Thus in honey dressed wounds, early subsidence of acute inflammatory changes, better control of infection and quicker wound healing was observed while in the SSD treated wounds sustained inflammatory reaction was noted even on epithelialization.
Int J Clin Pract. 2007 Oct;61(10):1705-1707.
Honey: nutritional and medicinal value.
LLyes”˜Onnen ysbyty gwynedd, NHS Trust
Honey is not only used as nutrition but also used in wound healing and as an alternative treatment for clinical conditions ranging from gastrointestinal tract (GIT) problems to ophthalmic conditions. We did the literature search and found interesting facts about the nutritional and medicinal value of honey. No wonder, it is a good source of nutrition, the results of the studies prove that it also helps in wound healing. On burns, it has an initial soothing and later rapid healing effects. It has been used as wound barrier against tumour implantation in laparoscopic oncological surgery. No infection has been reported from the application of honey to open wounds. It has a potential therapeutic role in the treatment of gingivitis and periodontal disease. Based on these facts, the use of honey in the surgical wards is highly recommended and patients about to undergo surgery should ask their surgeons if they could apply honey to their wounds postoperation.
Arch Surg. 2000 Dec;135(12):1414-7.
Comment in:
Arch Surg. 2001 May;136(5):600.
Protective covering of surgical wounds with honey impedes tumor implantation.
Hamzaoglu I, Saribeyoglu K, Durak H, Karahasanoglu T, Bayrak I, Altug T, Sirin F, Sariyar M.
Department of Surgery,
HYPOTHESIS: Tumor implantation (TI) development at the surgical wound following cancer surgery is still an unresolved concern. Trocar site recurrence, which is likely a form of TI, has become one of the most controversial topics and, with the widespread acceptance of laparoscopic surgery, has caused renewed interest in questions about TI. Honey has positive effects on wound healing. Physiological and chemical properties of honey might prevent TI when applied locally. DESIGN, INTERVENTIONS, AND MAIN OUTCOME MEASURES: Sixty BALB/c strain mice, divided into 2 groups, were wounded in the posterior neck area. Group 1 mice formed the control group, and group 2 mice had wounds coated with honey before and after tumor inoculation. All wounds were inoculated with transplantable Ehrlich ascites tumor. The presence of TI was confirmed in the wounded area by histopathological examination on the 10th day. RESULTS: Tumor implantation was achieved in all group 1 animals and verified by palpable mass and histopathological examination. In group 2 mice, although TI could not be detected macroscopically, it was revealed by pathological examination in 8 cases. Tumor implantation was less likely in group 2 mice (8 of 30 vs 30 of 30; P<.001). CONCLUSIONS: Tumor implantation was markedly decreased by the application of honey pre- and postoperatively. It is possible that the physiological and chemical properties of honey protected wounds against TI. Honey could be used as a wound barrier against TI during pneumoperitoneum in laparoscopic oncological surgery and in other fields of oncological surgery.
Zentralbl Veterinarmed A. 1998 Apr;45(3):181-8.
Effects of topical application of honey on cutaneous wound healing in rabbits.
Pathology Department,
Although it has been known for many centuries that honey can accelerate wound healing, there have only been isolated reports of its use in the healing of burns, ulcers, infected wounds and open wounds. None of these reports developed a model to assess the changes in morphological and biochemical properties due to topical application of honey on cutaneous wounds. In the present investigation, efficacy of honey in the healing of cutaneous wounds of rabbits was studied on the basis of histopathological and biochemical changes. For this reason 40 healthy White New Zealand rabbits were randomly assigned to four equal groups. Using aseptic surgical technique, a 3 cm incision was made on the skin of the left thigh of each rabbit and the wounds of five rabbits in each group were twice daily treated with topical application of 5 ml pure unheated honey. The other half remained as untreated controls. Rabbits in groups A, B, C and D were biopsied on days 2, 7, 14 and 21 postoperatively respectively, and biopsies from the lesions of all groups were collected for histopathological studies and from groups C and D for biomechanical evaluations as well. Treated lesions showed less oedema, fewer polymorphonuclear and mononuclear cell infiltration, less necrosis, better wound contraction, improved epithelialization and lower glycosaminoglycan and proteoglycan concentration on days 2 and 7 postoperatively and better tissue organization and consequently an improved tissue ultimate strength and yield strength on days 14 and 21 postoperation. These findings suggest that honey applied topically on cutaneous wounds accelerates the healing processes and appears to have an important property that makes it ideal as a dressing for cutaneous wounds.
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Honey: nutritional and medicinal value. |
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Healing honey. |
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The therapeutic use of honey. |
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Effects of honey and sugar dressings on wound healing. |
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A 5.8-kDa component of manuka honey stimulates immune cells via TLR4. |
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Honey–the wonder of ‘liquid gold’. |
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Wound healing with honey–a randomized controlled trial. |
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Effect of topical honey application along with intralesional injection of glucantime in the treatment of cutaneous leishmaniasis. |
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Effectiveness of a honey dressing for healing pressure ulcers. |
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[Honey for wound healing?] |
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Combined use of honey, bee propolis and myrrh in healing a deep, infected wound in a patient with diabetes mellitus. |
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Intraurethral honey application for urethral injury: an experimental study. |
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Wound healing with honey–a randomised controlled trial. |
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Free radical production and quenching in honeys with wound healing potential. |
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Topical antimicrobials in the control of wound bioburden. |
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The effect of honey compared to conventional treatment on healing of radiotherapy-induced skin toxicity in breast cancer patients. |
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Treatments for damaged skin. |
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A comparison of wound healing following treatment with Lavandula x allardii honey or essential oil. |
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Honey dressings: the need for specification. |
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Honey dressings in wound care. |
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Case series of use of Manuka honey in leg ulceration. |
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Honey dressing versus paraffin tulle gras following toenail surgery. |
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Commentary on “the evidence supporting the use of honey as a wound dressing” by P. C. Molan. |
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The evidence supporting the use of honey as a wound dressing. |
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Healing with animals in the |
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Communal use of integumental wounds in honey bee (Apis mellifera) pupae multiply infested by the ectoparasitic mite Varroa destructor. |
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The benefits of honey in wound management. |
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28: |
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Using honey to heal a chronic wound in a patient with epidermolysis bullosa. |
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29: |
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Using honey to heal a chronic wound in a patient with epidermolysis bullosa. |
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It’s all the buzz. |
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Turmeric (Curcuma longa) rhizome paste and honey show similar wound healing potential: a preclinical study in rabbits. |
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Honey for refractory diabetic foot ulcers. |
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Wound care with antibacterial honey (Medihoney) in pediatric hematology-oncology. |
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[Effect of honey and autologous serum on corneal epithelial healing in rabbits.] |
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The use of honey as a topical dressing to treat a large, devitalized wound in a stumptail macaque (Macaca arctoides). |
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Comparison of healing of incised abscess wounds with honey and EUSOL dressing. |
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Treatment of a venous leg ulcer with a honey alginate dressing. |
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38: |
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Topical honey for diabetic foot ulcers. |
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39: |
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The use of honey-derived dressings to promote effective wound management. |
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Topical treatments in equine wound management. |
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[Propolis. The bee glue as presented by the Graeco-Roman literature] |
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Use of medical honey in patients with chronic venous leg ulcers after split-skin grafting. |
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Phenoloxidase activity in Apis mellifera honey bee pupae, and ecdysteroid-dependent expression of the prophenoloxidase mRNA. |
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Clinical usage of honey as a wound dressing: an update. |
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45: |
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Efficacy of natural honey in the healing of leg ulcers in sickle cell anaemia. |
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Enhanced wound contraction in fresh wounds dressed with honey in Wistar rats (Rattus Novergicus). |
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Topical honey application vs. acyclovir for the treatment of recurrent herpes simplex lesions. |
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Evaluation of a honey-impregnated tulle dressing in primary care. |
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Acceptability to patients of a honey dressing for non-healing venous leg ulcers. |
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50: |
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A critical review of natural therapies in wound management. |
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The effects of manuka honey on plaque and gingivitis: a pilot study. |
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A comparative study of the wound healing properties of honey and Ageratum conyzoides. |
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Identification of nitric oxide metabolites in various honeys: effects of intravenous honey on plasma and urinary nitric oxide metabolites concentrations. |
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54: |
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The use of honey for the treatment of two patients with pressure ulcers. |
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55: |
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[Honey’s virtues in theriacs] |
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56: |
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Honey stimulates inflammatory cytokine production from monocytes. |
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57: |
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The effect of dilution on the rate of hydrogen peroxide production in honey and its implications for wound healing. |
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58: |
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Predisposing factors and treatment outcome in Fournier’s gangrene. Analysis of 28 cases. |
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59: |
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Traditional healing with animals (zootherapy): medieval to present-day Levantine practice. |
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60: |
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Honey-medicated dressing: transformation of an ancient remedy into modern therapy. |
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Use of honey as an adjunct in the healing of split-thickness skin graft donor site. |
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Bacteria can’t resist honey. |
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63: |
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Honey cream. |
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Wound pathophysiology, infection and therapeutic options. |
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65: |
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The biochemistry and medical significance of the flavonoids. |
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66: |
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Honey: a potent agent for wound healing? |
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67: |
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Commentary–” Honey: a potent agent for wound healing? “. |
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Re-introducing honey in the management of wounds and ulcers – theory and practice. |
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Honey as a dressing for chronic wounds in adults. |
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The role of intra-peritoneal honey administration in preventing post-operative peritoneal adhesions. |
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Healing of an MRSA-colonized, hydroxyurea-induced leg ulcer with honey. |
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72: |
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Bi-lateral eosinophilic ulcers in an infant treated with propolis. |
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73: |
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Treatment of an infected venous leg ulcer with honey dressings. |
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74: |
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The potential of honey to promote oral wellness. |
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75: |
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Honey and sugar as a dressing for wounds and ulcers. |
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76: |
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The use of honey in wound management. |
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77: |
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Treatment of a wound infection in a patient with mantle cell lymphoma. |
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Why do some cavity wounds treated with honey or sugar paste heal without scarring? |
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79: |
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Manuka honey used to heal a recalcitrant surgical wound. |
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80: |
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Potential of honey in the treatment of wounds and burns. |
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81: |
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Honey, a prospective antibiotic: extraction, formulation, and stability. |
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82: |
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Myth: silver sulfadiazine is the best treatment for minor burns. |
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83: |
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Stimulation of TNF-alpha release in monocytes by honey. |
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84: |
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Systematic review of the use of honey as a wound dressing. |
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85: |
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A comparison of topical honey and phenytoin in the treatment of chronic leg ulcers. |
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86: |
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Elucidation of active anticancer agents in naturally occurring substances. |
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87: |
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Protective covering of surgical wounds with honey impedes tumor implantation. |
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88: |
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Detection of antimicrobials in bee products with activity against viridans streptococci. |
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89: |
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Anti-ulcerogenic effect of Momordica charantia L. fruits on various ulcer models in rats. |
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90: |
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The nutraceutical benefit, part iii: honey. |
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91: |
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Eusol management of burns. |
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92: |
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Honey and sugar as a dressing for wounds and ulcers. |
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93: |
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The role of honey in the management of wounds. |
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94: |
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Honey in wound care. |
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95: |
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Complementary and alternative medicine in wound healing. |
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96: |
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Early tangential excision and skin grafting of moderate burns is superior to honey dressing: a prospective randomised trial. |
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97: |
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Recombinant growth factors or honey? |
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98: |
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Honey and wound bacteria. |
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99: |
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Effects of topical honey on post-operative wound infections due to gram positive and gram negative bacteria following caesarean sections and hysterectomies. |
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100: |
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[Treatment of perineal and genital gangrene with honey] |
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101: |
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Effects of topical application of honey on cutaneous wound healing in rabbits. |
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102: |
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Local application of honey for treatment of neonatal postoperative wound infection. |
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103: |
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A prospective randomised clinical and histological study of superficial burn wound healing with honey and silver sulfadiazine. |
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104: |
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Manuka honey and leg ulcers. |
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105: |
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An overview of the topical management of wounds. |
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106: |
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Minor burns and hand burns: comparing treatment methods. |
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107: |
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Spirit of the beehive. |
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108: |
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[Honey–a food and a remedy] |
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109: |
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Honey dressing versus boiled potato peel in the treatment of burns: a prospective randomized study. |
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110: |
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Genital Fournier’s gangrene: experience with 38 patients. |
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111: |
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[Nonnius, ‘dietetics’ and oenology] |
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112: |
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The sterilization of honey with cobalt 60 gamma radiation: a study of honey spiked with spores of Clostridium botulinum and Bacillus subtilis. |
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113: |
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[Honey and wound healing] |
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114: |
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[Honey: a potential wound-healing agent with antibacterial activity] |
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115: |
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Honey impregnated gauze versus polyurethane film (OpSite) in the treatment of burns–a prospective randomised study. |
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116: |
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[Clinical and bacteriological outcome of wounds treated with honey. An analysis of a series of 40 cases] |
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117: |
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Topical application of honey in treatment of abdominal wound disruption. |
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118: |
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[Treatment of wounds with honey. 40 cases] |
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119: |
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Sickle cell leg ulcers in |
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120: |
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[Honey on the wound] |
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121: |
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Honey and healing of leg ulcers. |
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122: |
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Honey and healing. |
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123: |
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Topical application of honey in treatment of burns. |
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124: |
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[The use of honey in the process of scar formation. From the hive to the hospital] |
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125: |
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Honey and healing. |
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126: |
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Wound healing and current dermatologic dressings. |
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127: |
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Reply: honey and propolis as possible promoters of the healing of ulcers in leprosy. |
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128: |
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Clinical observations on the wound healing properties of honey. |
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129: |
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Acceleration of wound healing by topical application of honey. An animal model. |
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130: |
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[Allogenic transplantation of sterilised bones and halfjoints (author’s transl)] |
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131: |
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Radical operation for carcinoma of the vulva. A new approach to wound healing. |
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132: |
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[Honey, miraculous and healing food.] |
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