Dr. Weeks’ Comment:  “Iatrogenesis”, a word they teach all 3rd medical students as we swarm out of the classrooms and into the real world of the hospitals, is rarely mentioned, except behind the closed doors of a Grand Rounds  or at  “M&M” meetings.   (M&Ms  are the weekly events where doctors get together and scratch their heads about troubling cases while meeting to discuss reasons for morbidity and mortality (M&M).  Here doctors review details to try and learn  1)where  things went wrong,  2) why things went wrong and 3) what we can do to prevent future tragedies.  At every step of the way, nobody mentions the word “iatrogenesis” but we are all thinking it.

The first death I ever experienced while in medical school occurred in a hospital setting and was clearly caused by the attending doctor ordering the wrong medicine followed by an fatal allergic response in an already dying elderly man.  When the error was reported to the Attending  the next morning, he responded to his medical team of residents and medical students all  gathered to receive his wisdom (and I will remember his  response to my own dying day) with the following casual  assessment:  “Well, live and learn.”    –  I thought to myself: “That is easy for you to say since you are the  one who gets to live AND learn but what about the patient who was killed by your error!”   It was my first direct experience with iatrogenesis. Death caused by a well-intended but erring or careless doctor. In civil courts, you might know this act by another term: second -degree murder.

A new form of iatrogenesis is spreading across the land. Today, as  Nicholas  Kristoff  of the NYTimes points out, something approaching murder, agricultural iatrogenesis for profit,  is seeping out and into all our commercially prepared food.  The FDA, bought and sold to Industry (actually staffed by industry according to most current analysis https://weeksmd.com/?p=3387 and http://www.psrast.org/ecologmons.htm ) is not protecting us and so, as Kristoff concludes,  the witches cauldrons of agribusiness where our food is produced today on  Pharms and no longer on family farms has resulted in our  “brewing some perfect storms”.

“Trust me, I’m your farmer.”  or “Trust me, I’m your grocer.”  rings as hollow today as “Trust me, I’m your doctor” rang in the ears of a young medical student who was being trained to “live and learn”  many years ago.

“Iatrogenesis.”    Look it up.  Learn its definition. Teach it to your friends.  Ask your doctor about it!  Live it up a bit and learn, while you have your health (assuming, of course, that you are already eating organic…)

March 7, 2010
Op-Ed Columnist

The Spread of Superbugs



Until three months ago, Thomas M. Dukes was a vigorous, healthy executive at a California plastics company. Then, over the course of a few days in December as he was planning his Christmas shopping, E. coli bacteria ravaged his body and tore his life apart.

Mr. Dukes is a reminder that as long as we’re examining our health care system, we need to scrutinize more than insurance companies. We also need to curb the way modern agribusiness madly overuses antibiotics, leaving them ineffective for sick humans.

Antibacterial drugs were revolutionary when they were introduced in the United States in 1936, virtually eliminating diseases like tuberculosis here and making surgery and childbirth far safer. But now we’re seeing increasing numbers of superbugs that survive antibiotics. One of the best-known ”” MRSA, a kind of staph infection ”” kills about 18,000 Americans annually. That’s more than die of AIDS.

Mr. Dukes, 52, picked up a kind of bacteria called ESBL-producing E. coli. While it’s conceivable that he touched a contaminated surface, a likely scenario is that he ate tainted meat, said Dr. Brad Spellberg, an infectious-diseases specialist and the author of “Rising Plague,” a book about antibiotic resistance.

Vegetarians are also vulnerable to antibiotic resistance nurtured in hog barns. Microbes swap genes, so antibiotic resistance developed in pigs can jump to microbes that infect humans in hospitals, locker rooms, schools or homes.

Routine use of antibiotics to raise livestock is widely seen as a major reason for the rise of superbugs. But Congress and the Obama administration have refused to curb agriculture’s addiction to antibiotics, apparently because of the power of the agribusiness lobby.

The ESBL E. coli initially remained in Mr. Dukes’s colon, causing no particular damage. But then he suffered an inflammation that perforated his colon ”” and the bacteria escaped.

Mr. Dukes began suffering stomach pains and saw his doctor, who gave him Cipro, a strong antibiotic that had previously worked against the infection. This time, the pain grew worse. The next evening, he was in surgery to remove eight inches of his colon.

A culture attributed the infection partly to ESBL E. coli. Doctors inserted a tube to administer an intravenous antibiotic in an effort to save his life.

If ESBL E. coli is frightening, there are even more potent superbugs emerging, like Acinetobacter.

“We are seeing infections caused by Acinetobacter and special bacteria called KPC Klebsiella that are literally resistant to every antibiotic that is F.D.A. approved,” Dr. Spellberg said. “These are untreatable infections. This is the first time since 1936, the year that sulfa hit the market in the U.S., that we have had this problem.”

The Infectious Diseases Society of America, an organization of doctors and scientists, has been bellowing alarms. It fears that we could slip back to a world in which we’re defenseless against bacterial diseases.

There’s broad agreement that doctors themselves overprescribe antibiotics ”” but also that a big part of the problem is factory farms. They feed low doses of antibiotics to hogs, cattle and poultry to make them grow faster.

A study by the Union of Concerned Scientists found that in the United States, 70 percent of antibiotics are used to feed healthy livestock, with 14 percent more used to treat sick livestock. Only about 16 percent are used to treat humans and their pets, the study found.

More antibiotics are fed to livestock in North Carolina alone than are given to humans in the entire United States, according to the peer-reviewed Medical Clinics of North America. It concluded that antibiotics in livestock feed were “a major component” in the rise of antibiotic resistance.

Legislation introduced by Louise Slaughter, a New Yorker who is the only microbiologist in the House of Representatives, would curb the routine use of antibiotics in farming. The bill has 104 co-sponsors, but agribusiness interests have blocked it in committee ”” and the Obama administration and the Senate have dodged the issue.

After weeks of receiving intravenous antibiotics, Mr. Dukes is now recovering at home in Lomita, Calif. He must use a colostomy bag, but he hopes to be patched up and ready to return to work next month. Still, he knows that the ESBL E. coli remains in his gut.

“As long as it’s contained in my colon, I’m a happy camper,” he said. “But if it gets out again, I’m in trouble.”

Dr. Martin J. Blaser, chairman of the department of medicine at New York University Langone Medical Center, and a former president of the Infectious Diseases Society of America, agrees that agricultural use of antibiotics produces cheaper meat. But he says the price may be an enormous toll in human health.

“You could have very lethal pandemics,” he said. “We’re brewing some perfect storms.”




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