Correcting Diabetes

Dr. Weeks’ Comment: Anyone who has paid even passing attention to holistic medicine over the past 2 decades understands that type 2 diabetes is not a disease, it is an eating disorder and as such, can be corrected not with drugs but with more intelligent selection of food.  Food combining diet, apitherapy diet, Paleo diet,  Atkins diet, raw foods diet  – all these correct diabetes.  But as most doctors know, people want to be given a pill:

 William Osler, M.D. clarified this:

“The desire to take medicine is perhaps the greatest feature which distinguishes man from animals.”    

and also:  

” The first duties of the physician is to educate the masses not to take medicine.”


More cutting are the words of Jarod Kintz: 

“A traditional doctor gets paid to push pills, vaccinate, radiate, and basically exterminate people. No different than a contract killer””except the hit man is more honest, as he doesn’t claim to be helping humanity. Holistic medicine is the only way to go. ”¨” 
”• Jarod KintzSeriously delirious, but not at all serious


New Multiple Action Intestinal Hormone Corrects Diabetes

Oct. 30, 2013 ”” Scientists from the Helmholtz Zentrum München (HMGU) and the Technische Universität München (TUM), together with scientists in the USA, have developed a new therapeutic approach for treatment of type 2 diabetes. A novel single molecule hormone, which acts equally on the receptors of the insulin-stimulating hormones GLP-1 and GIP, was observed to reduce weight and improve blood sugar. The results have now been published in the medical journal ‘Science Translational Medicine’, and include data from successful clinical studies in partnership with the pharmaceutical company Roche.

GLP-1 (glucagon-like peptide 1) and GIP (gastric inhibitory peptide) are hormones that are formed by the digestive tract and that control food intake and numerous metabolic processes. When glucose (sugar) is ingested, these hormones primarily lead to increased insulin release and subsequent reduction in blood sugar, but they also affect appetite regulation and fat burning.

Some of the actions, which are combined in one molecule for the first time, are already in use for the treatment of type 2 diabetes. GLP-1 analogues, as well as DPP4 (dipeptidyl peptidase 4) inhibitors, which are thought to enhance GLP-1 action, are used to reduce blood sugar. A HMGU and TUM team led by Dr. Brian Finan and Prof. Dr. Matthias Tschöp at the Helmholtz Diabetes Center, working with Richard DiMarchi from Indiana University and colleagues from the University of Cincinnati, have now succeeded in developing a molecular structure that combines the effects of the two hormones. These novel molecules simultaneously stimulate two receptors (GLP-1 and GIP) and consequently maximize metabolic effects compared to each of the individual molecules, or currently available medicines that are based on individual intestinal hormones.

The newly discovered GLP-1/GIP co-agonists lead to improved blood sugar levels and to a significant weight loss and lower blood fat. Importantly, the researchers observed that the new substance also improved metabolism in humans, in addition to beneficial effects they discovered in several animal models. At the same time, there are indications that possible adverse effects, the most frequent of which are gastrointestinal complaints, are less common and less pronounced with this approach than with the individual hormones.

“Our results give us additional confidence that our combinatorial approach of modulating brain regulatory centers via natural gut hormone signals has superior potential for a transformative diabetes treatment,” explains Prof. Tschöp. He adds a note of caution however: “Still, this approach has to go through several more years of intense research, clinical testing, and safety evaluations, before these substances may become available for patients.” Dr. Finan, the first author of the study, points out that there may be unprecedented potential: “We are quite excited about this new multi-functional agent approach and believe it could become an integral part of a next generation of personalized therapies for type 2 diabetes, as the ratio of the GLP-1 and GIP signal strengths could be adjusted depending on the individual needs of patients.”

The studies which were just published in Science Translational Medicine are perfectly aligned with the research objective of at the Helmholtz Zentrum München, partner of the German Center for Diabetes Research (DZD), which is to establish new approaches to the diagnosis, therapy and prevention of civilization’s major widespread diseases and to further develop these approaches as quickly as possible in the context of translational research in order to provide specific benefits for society.


Journal Reference:

  1. B. Finan, T. Ma, N. Ottaway, T. D. Muller, K. M. Habegger, K. M. Heppner, H. Kirchner, J. Holland, J. Hembree, C. Raver, S. H. Lockie, D. L. Smiley, V. Gelfanov, B. Yang, S. Hofmann, D. Bruemmer, D. J. Drucker, P. T. Pfluger, D. Perez-Tilve, J. Gidda, L. Vignati, L. Zhang, J. B. Hauptman, M. Lau, M. Brecheisen, S. Uhles, W. Riboulet, E. Hainaut, E. Sebokova, K. Conde-Knape, A. Konkar, R. D. DiMarchi, M. H. Tschop. Unimolecular Dual Incretins Maximize Metabolic Benefits in Rodents, Monkeys, and Humans. Science Translational Medicine, 2013; 5 (209): 209ra151 DOI: 10.1126/scitranslmed.3007218

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