Dr. Weeks’ Comment: We know that the ingredients in SOUL help people require less psychiatric medications in general, and we know that inflammation worsens psychosis as well as all psychiatric problems, so it is encouraging that more doctors are prescribing anti-inflammatory agents and less anti-psychotic or anti-depressant medications. Recently, so many people have called me with gratitude that SOUL, the nutrient dense drink made from ground up organic non-GMO seeds from anti-inflammatory plants, has lowered their anxiety and cut their panic that we had to go to the scientific literature to better understand how it helps anxiety in particular.
“…NS as a nutritional supplement been observed to- stabilize mood, decrease anxiety and modulate cognition positively…”
“…Based on this, it may be suggested that N. sativa oil is a useful choice for the treatment of anxiety…”
Previous studies conducted on animals linked consumption of Nigella sativa L. seeds (NS) to decreased anxiety and improved memory. The present study, which was carried out at a boarding school in Bangladesh, was designed to examine probable effect of NS on mood, anxiety and cognition in adolescent human males.
MATERIALS AND METHODS:
Forty-eight healthy adolescent human males aged between 14 to 17 years were randomly recruited as volunteers and were randomly split into two groups: A (n=24) and B (n=24). The treatment procedure for group A and B were one capsule of 500 mg placebo and 500 mg NS respectively once daily for four weeks. All the volunteers were assessed for cognition with modified California verbal learning test-II (CVLT-II), mood with Bond-Lader scale and anxiety with State-TraitAnxiety Inventory (STAI) at the beginning and after four weeks of either NS or placebo ingestion.
Over the 4 weeks study period, the use of NS as a nutritional supplement been observed to- stabilize mood, decrease anxiety and modulate cognition positively. However, long term study is suggested before using NS extensively.
Repeated administration of Nigella sativa decreases 5-HT turnover and produces anxiolytic effects in rats.
The black cumin or Nigella sativa L. seeds have many acclaimed medicinal properties. Pharmacological studies have been conducted on the aqueous and methanol extracts of N. sativa L. seeds to evaluate their effects on the central nervous system. In the present study, N. sativa oil was used to study its effect on anxiety in rats. Open field and elevated plus maze models were selected for the evaluation of anxiolytic effect of drug. After four weeks of daily administration of drug, the rats exhibited an increase in open field activity. The drug also produced anti-anxiety effect in rats when tested in elevated plus maze. Concentrations of 5-HT, 5-HIAA in brain and concentrations of plasma and brain tryptophan determined by HPLC-EC detector. Result shows that oral administration of N. sativa oil increased brain levels of 5-HT but the levels of brain 5-HIAA decreased significantly. Brain and plasma levels of tryptophan also increased significantly following oral repeated administration of N. sitiva oil. Based on this, it may be suggested that N. sativa oil is a useful choice for the treatment of anxiety.