Lunasin and Lung Cancer

Dr. Weeks’ Comment: Lunasin is yet another example of seed based nutrition offering powerful medicinal effects via anti-inflammatory mechanisms. In this instance, anti-cancer.  Lunasin from soy or wheat or other seeds is powerful in myriad ways: anti-inflammation, stimulating P21 and P27  as well as promoting apoptosis and cancer cell destruction.

“…Lunasin has been shown to suppress signaling through the FAK/ERK/NF-κB pathway in colon cancer cells [31] and Akt/NF-κB signaling in macrophages during activation of lipopolysaccharide-induced inflammation…”


The soybean-derived peptide lunasin inhibits non-small cell lung cancer cell proliferation by suppressing phosphorylation of the retinoblastoma protein


 Elizabeth J. McConnell1, Bharat Devapatla2, Kavitha Yaddanapudi2,3 and Keith R. Davis1,2,4


Lunasin, a soybean bioactive peptide, has both chemopreventive and chemotherapeutic activities. The aim of this study was to determine the chemotherapeutic potential of lunasin against human lung cancer. Treatment of non-small cell lung cancer (NSCLC) cells with highly purified soybean-derived lunasin caused limited, cell-line specific anti-proliferative effects on anchorage-dependent growth whereas two normal bronchial epithelial cell lines were unaffected. Lunasin’s antiproliferative effects were potentiated upon utilization of anchorage-independent conditions. Furthermore, NSCLC cell lines that were unaffected by lunasin in anchorage-dependent assays exhibited a dose-dependent inhibition in colony formation or colony size. Mouse xenograft studies revealed that 30 mg lunasin/kg body weight per day decreased NSCLC H1299 tumor volume by 63.0% at day 32. Mechanistic studies using cultured NSCLC H661 cells showed that lunasin inhibited cell cycle progression at the G1/S phase interface without inducing apoptosis. Immunoblot analyses of key cell-cycle proteins demonstrated that lunasin altered the expression of the G1 specific cyclin-dependent kinase complex components, increased levels of p27Kip1, reduced levels of phosphorylated Akt, and ultimately inhibited the sequential phosphorylation of the retinoblastoma protein (RB). These results establish for the first time that lunasin can inhibit NSCLC proliferation by suppressing cell-cycle dependent phosphorylation of RB.



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