Anti-Aging 2001

Dr. Weeks’ Comment:


“Do Not Go Gentle…”

The 2001 Anti-Aging Lecture in Perth Australia

Perth, Australia

October 8th 2001


Bradford S. Weeks, M.D


“The goal, after all, is to die young, as late as possible.”




20% of the world’s population will be older than 65 within the next 25 years.


Major diseases of aging are responsible for over 85% of deaths of middle-aged and elderly individuals.

  • obesity,
  • atherosclerosis,
  • hypertension,
  • diabetes,
  • cancer,
  • autoimmune disorders,
  • metabolic immuno-depression,
  • osteoporosis hip fracture
  • Two other diseases”” depression and menopause””although not fatal, also occur regularly with age.





Arthur Balin   MD, PhD

Lifetime Energy Allocation (LEA) – only so many breaths/ejaculations allowed per life time


Dr. Eli Metchnikoff “father of Gerentology”

Auto-intoxication from the leaky gut syndrome;


Professor Vladimir Dilman (1954), aging is caused by cerebral hormonal exhaustion

Pineal & Hypothalamus & Pituitary

The problem is that homeostasis breaks down due to progressive insensitivity to negative feedback inhibition.


It is the breakdown or alteration in the functioning of these glands which causes the metabolic changes that characterize. The most prevalent of these changes include

(1) reduction in glucose tolerance,

(2) hyperinsulinemia,

(3) hyperlipidemia.






The Myriad Theories of Aging




What are the factors that influence aging?


1) Caloric restriction

  • “If Americans ate half as much they would live twice as long.”   Ben Franklin


  • Since 1940, this is the most reproducible way of extending lifespan in animal models (protozoans to rhesus monkeys, to rats, to birds, to pigs and to dogs (Weindruch)


  • Lowers incidence of cancer, heart disease, diabetes, syndrome X, neurodegenerative disorders


  • Reduced oxidative stress by lowering glucose concentrations and slowing metabolic rate thereby producing less free radicals toxins;


  • Caenorhabditis elegans and the daf-2 protein.




2) Hyperinsulinemia and poor glucose control with hypoglycemia


  • AGEs (advanced glycosylation end products) aka Amadori Products


  • Cross linking of proteins – rigidity – lack of elasticity (skin and cataracts)


  • Reve the engine and pop the clutch


3) Inventory Imbalance

  • depletion syndromes – wear and tear effect


  • poor lifestyle (nicotine, sugar, alcohol)



4) Elevated Metabolic rate

  • Burning the candle at both ends


5)   Bad Luck with Bad genes






A Unifying Theory of Aging



Aging is biochemical rusting.




Aging is a failure of myriad anti-oxidant protective biochemical mechanisms due to

  • excesses of free radicals,


  • excesses of metabolic toxins


and / or


  • deficiencies of anti-oxidants (vitamin and mineral nutrients)



Research Consensus




“In young animals the opposing forces are well matched, but with aging the balance is tilted to a pro-oxidant state, largely because of increased production of free radicals.”

Raj Sohal, Ph.D.

  1. Methodist University Dallas, TX





Species with faster metabolic rates

accumulate and leak out more damaging

free radical molecules

and live shorter lives than those

with slower metabolic rates

(example: lipofuscin accumulates)










“Never Lock the Robber in the House”



Medications that eliminate symptoms

Remember that symptoms are healing gestures.


The cell with normal metabolic waste products (garbage)

The cell with abnormal metabolic waster products (xenoestrogen)


Tri halogen derivatives: Aluminum cross linking (like halogen) has 3 arms to cross link (calcium has one) so aggregation occurs;

Chloroform also has 3 arms – trivalent – shows cross linking of chromosomes – genetic toxin;


Nonenzymative cross linking: glucose and amino group make an Amadori product which can become “advanced glycosylation end products” (AGEs)

AGEs formed with macromolucules to become proteolytically indigestible and clog up the works;



My favorite Axe





Discuss the Cliff metaphor


‘Anti-ageing’ pill on sale in France

by Zoe Morris and Toby Rose

A “miracle” pill said to reverse ageing and restore libido has gone on sale in French chemists today.

The controversial hormone DHEA, or dehdroepiandrosterone, is produced naturally by the body but levels diminish after the age of 30.

Studies in France appear to have shown that by taking the hormone as a supplement the skin, bones and libido are strengthened.


….Only last week the Evening Standard revealed that the French had come up with a similar pill to simulate the effects of red wine. The powdered wine tablets contain all the beneficial ingredients of vin rouge but no alcohol.

Made with grapes from the CTMtes du RhTMne and Roussillon wine-growing regions, they have been developed by around 20,000 producers from south-west France. The health-boosting polyphenols in red wine are reputed to help prevent illnesses ranging from Alzheimer’s dis-ease to heart attacks.





This needs to be modified depending upon the specific toxicities and deficiencies of the patient.


  1. Follow a low glycemic diet (eat less, chew your food and consider digestive aids)


  1. Drink plenty of healthy water (away from meals)


  1. Exercise regularly (enhances glucagon and reduces insulin levels) Reducing weight by about 10 to 15 pounds and exercising about 30 minutes a day – could cut the risk of type 2 diabetes by nearly 60 percent in a group of high-risk people one step short of having the full-blown disease.



  1. A good vitamin mineral supplement with chelated minerals (not magnesium oxide or calcium carbonate) including:
  • Chromium 200-800 mcg (Glucose Tolerance Factor facilitates glucose uptake in cells)
  • Vanadium 50-150 mcg (mimics insulin so reduces insulin levels)
  • Niacin   500-5000 mg three times a day with food (watch the flush!)
  • Vitamin C (sodium ascorbate) 1000mg three times a day
  • Selenium 200mcg three times a day (protects heart and enhances cellular metabolism)
  • Alpha lipoic acid   100mg three times a day (water and fat soluble anti-oxidant, enhances vitamin C and lowers glucose)
  • The d, alpha tocopherol (not “d,l- alpha…”) – vitamin E for antiplatelet aggregation and anti-oxidant benefit

4) A sleep aid such as Melatonin   1-3 mg at night

5) Essential Fatty Acid (a blend of oils including flax/borage/evening primrose oils)

6) A sense of enthusiasm, purpose and enjoyment.



1) Metformin two or three times per day (structurally similar to guanadine which has been used to treat diabetes – serves to increase peripheral insulin sensitivity – like Goats Rue (Gallega officinalis)

2) Phosphatidyl choline and phosphatidyl serine, gingko biloba, vinpocetin, huperizine, DMAE, DMPS, EDTA – garlic….

3)   Hormone replacement after age 30 only with monitoring from a laboratory

  • DHEA 10 – 50 mg a day
  • Pregnenolone 10-100 mg a day
  • Melatonin 1-6mg at night
  • Progesterone (in women)
  • Human Growth Hormone (HGH) 1 unit a day


3) Hormone replacement after change of life

  • Testosterone (dosage per laboratory results)
  • Estrogen (dosage per laboratory results)
  • Progesterone (dosage per laboratory results)





Plastic surgeon cartoon


The time of your life

The 5 affirmations


The Wave








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