Dr. Weeks’ Comment: High dose melatonin (60-180mg/ day) is very beneficial because this agent is a powerful water and fat soluble anti-oxidant and also a powerful anti-viral. Here is an impressive study. “Melatonin, nitric oxide and ascorbic acid can reduce COVID-19 virulence by inhibiting NLRP3 inflammasomes to stop the perpetuation of cytokine storms.“
“It is now clear as crystal why authorities and medical experts, scientists around the world are deeply concerned over the spread of COVID-19. SARS-CoV-2 is a coronavirus that uses the same deadly mechanisms as SARS-CoV to activate NLRP3 inflammasomes to initiate cytokine storms that can result in fatal acute respiratory distress syndrome and acute lung injury (ARDS/ALI).
SARS-CoV-2 may also be 1,000 times more infectious and virulent than SAR-CoV due to the furin cleavage site , which basically allows this coronavirus to be activated anywhere in host tissues and organs. Activation of SARS-CoV-2 allows it bind effectively to ACE2, causing more damage and destruction in the vital cardiovascular system and other critical pathways involving angiotensin-converting enzyme 2.
One important aspect that has not been elucidated is the importance of ACE2 in the progression of ARDS. Melatonin, nitric oxide and ascorbic acid (vitamin C) are all inextricably intertwined and deeply involved with ACE2. Melatonin, nitric oxide and ascorbic acid can reduce COVID-19 virulence by inhibiting NLRP3 inflammasomes to stop the perpetuation of cytokine storms. Their critical roles in biochemical reactions and biological pathways that involve ACE2 must be fully explored as part of our fight against COVID-19.”