Dr. Weeks’ Comment: More clinical trials are needed for this intriguing remedy.
“Experimental and clinical studies showed that BVT could be an effective adjuvant treatment for PD.”
Bee venom for the treatment of Parkinson’s disease: How far is it possible?
doi: 10.1016/j.biopha.2017.04.065. Epub 2017 May 4..
- PMID: 28477460
- DOI: 10.1016/j.biopha.2017.04.065
Parkinson’s disease (PD) is the second most common neurodegenerative disease, characterized by progressive loss of dopaminergic neurons in the substantia nigra pars compacta leading to depletion of striatal dopamine and motor symptoms as bradykinesia, resting tremors, rigidity, and postural instability. Current therapeutic strategies for PD are mainly symptomatic and may cause motor complications, such as motor fluctuations and dyskinesia. Therefore, alternative medicine may offer an effective adjuvant treatment for PD. Bee venom therapy (BVT) has long been used as a traditional therapy for several conditions, such as rheumatoid arthritis, asthma, and skin diseases. Experimental and clinical studies showed that BVT could be an effective adjuvant treatment for PD.Several mechanisms were suggested for these findings including the ability of BVT to attenuate neuroinflammation, inhibit apoptosis of dopaminergic neurons, protect against glutamate-induced neurotoxicity, and restore normal dopamine levels in the nigrostriatal pathway. In this article, we reviewed and summarized the literature regarding the potential of BVT for the treatment of PD.
Future research on bee venom for Parkinson’s disease
This review shows that BV should be further investigated as a possible adjuvant treatment for PD. Despite the positive findings of the experimental and early clinical studies, there are only few published data regarding the efficacy of BV for PD. Our systematic search on PubMed retrieved 35 records. Another search on SCOPUS using the term (Bee venom AND Parkinson’s disease) yielded 323 documents.
Venoms as an adjunctive therapy for Parkinson’s disease: where are we now and where are we going?
Free PMC article
Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in the aging population. Crucially, neurodegeneration of dopaminergic neurons in PD is associated with chronic inflammation and glial activation. Besides this, bradykinesia, resting tremor, rigidity, sensory alteration, and cognitive and psychiatric impairments are also present in PD. Currently, no pharmacologically effective treatment alters the progression of the disease. Discovery and development of new treatment strategies remains a focus for ongoing investigations. For example, one approach is cell therapy to prevent dopaminergic neuronal loss or to slow PD progression. The neuroprotective role of a diverse range of natural products, including venoms from bees, scorpions, snakes and lizards, are also being tested in preclinical PD models and in humans. The main findings from recent studies that have investigated venoms as therapeutic options for PD are summarized in this special report.
Bee Venom Alleviates Motor Deficits and Modulates the Transfer of Cortical Information through the Basal Ganglia in Rat Models of Parkinson’s Disease.PLoS One. 2015 Nov 16;10(11):e0142838. doi: 10.1371/journal.pone.0142838. eCollection 2015.PMID: 26571268 Free PMC article.
Effects of bee venom and dopamine-loaded nanoparticles on reserpine-induced Parkinson’s disease rat model.Sci Rep. 2021 Oct 27;11(1):21141. doi: 10.1038/s41598-021-00764-y.PMID: 34707203 Free PMC article.
Neuroprotective and Therapeutic Strategies against Parkinson’s Disease: Recent Perspectives.Int J Mol Sci. 2016 Jun 8;17(6):904. doi: 10.3390/ijms17060904.PMID: 27338353 Free PMC article. Review.
Disease modification in Parkinson’s disease.Drugs Aging. 2011 Aug 1;28(8):605-15. doi: 10.2165/11591320-000000000-00000.PMID: 21812497 Review.
Gene therapy in Parkinson’s disease: rationale and current status.CNS Drugs. 2010 Mar;24(3):177-92. doi: 10.2165/11533740-000000000-00000.PMID: 20155994 Free PMC article. Review.
Therapeutic Potential of Bee and Scorpion Venom Phospholipase A2 (PLA2): A Narrative Review.Iran J Med Sci. 2022 Jul;47(4):300-313. doi: 10.30476/IJMS.2021.88511.1927.PMID: 35919080 Free PMC article. Review.
Comparison of Metabolites and Gut Microbes between Patients with Parkinson’s Disease and Healthy Individuals-A Pilot Clinical Observational Study (STROBE Compliant).Healthcare (Basel). 2022 Feb 4;10(2):302. doi: 10.3390/healthcare10020302.PMID: 35206916 Free PMC article.
Acupuncture-Related Therapies for Parkinson’s Disease: A Meta-Analysis and Qualitative Review.Front Aging Neurosci. 2021 Jul 1;13:676827. doi: 10.3389/fnagi.2021.676827. eCollection 2021.PMID: 34276340 Free PMC article.
Bee venom attenuates neurodegeneration and motor impairment and modulates the response to L-dopa or rasagiline in a mice model of Parkinson’s disease.Iran J Basic Med Sci. 2020 Dec;23(12):1628-1638. doi: 10.22038/ijbms.2020.46469.10731.PMID: 33489038 Free PMC article.
Venoms as an adjunctive therapy for Parkinson’s disease: where are we now and where are we going?Future Sci OA. 2020 Nov 30;7(2):FSO642. doi: 10.2144/fsoa-2020-0119.PMID: 33437512 Free PMC article. Review.