SPMs are what you need to know about now.

Dr Weeks’ Comment:  If you are sick, most doctors today will give you antibiotics if it’s bacterial or antivirals if they suspect a viral infection, but no longer are doctors trained to give you bacteriophage therapy, or the newest remedy for enhancing immunity and resolving inflammation: specialized Pro-resolving, lipid mediators (SPMs). SPMs are the remedy of the future. We at TWCCH offer our patients cutting edge, scientifically validated treatments –  “tomorrow’s medicine today” – so read on and optimize your resilience against infection.


Role of specialized pro-resolving lipid mediators and their receptors in virus infection: a promising therapeutic strategy for SARS-CoV-2 cytokine storm

Chang Hoon Lee 1

Arch Pharm Res. 2021 Jan;44(1):84-98.

doi: 10.1007/s12272-020-01299-y. Epub 2021 Jan 4.

Read SOURCE article HERE.



Unexpected viral infections outbreaks, significantly affect human health, leading to increased mortality and life disruption. Among them is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which emerged as a deadly pandemic, calling for intense research efforts on its pathogenicity mechanism and development of therapeutic strategies. In the SARS-CoV-2 cytokine storm, systemic inflammation has been associated with severe illness and mortality. Recent studies have demonstrated special pro-resolving lipids mediators (SPMs) lipoxins, resolvins, maresins, and protectins as potential therapeutic options for abnormal viral-triggered inflammation. Pro-resolving lipids mediators have shown great promise for the treatment of Herpes simplex virus, respiratory syncytial virus, human immunodeficiency virus, and hepatitis C virus. Based on this, studies are being conducted on their therapeutic effects in SARS-CoV-2 infection. In this review, we discussed SPMs and reviewed evidence from recent studies on SPMs as therapeutic options for viral infections, including SARS-CoV2. Based on our analysis of the previous study, we argue that SPMs are a potential treatment for SARS-CoV-2 infection and other viral infections. We expect further research on how SPMs modulate viral-triggered inflammation through G-protein-coupled receptors (GPCRs), and chemical stability and druggability of SPMs.


Dr. Weeks’ Comment: Reminder, inflammation is a double-edged sword. It can help and it can hurt. Short term, acute inflammation enhances healing while chronic low grade inflammation harms. This of the difference between acute righteous indignation, and chronic resentment. Don’t hold grudges but speak out and get concerns off your chest then move on.


Specialized pro-resolving lipid mediators (SPMs)

Inflammation is an extremely important, self-limiting immune response; however, uncontrolled or unresolved inflammation has been established as a pathophysiological mechanism for various diseases including viral infections, and a cause for prolonged homeostasis imbalance. Resolution of inflammation occurs in an overlapping stage dominated by the spatial and temporal biosynthesis of pro-resolved mediators (Headland and Norling 2015), SPMs, from essential polyunsaturated fatty acids (PUFAs) during inflammation. The SPMs initiate the process of resolution which include restriction or cessation of neutrophil infiltration, counter-regulation of chemokines and cytokines, induction of the neutrophils apoptosis and subsequent efferocytosis (the process by which apoptotic cells are removed by phagocytic cells) by macrophages (Reville et al. 2006), the conversion of macrophages from classically activated (M1) to alternatively activated cells (M2), return of non-apoptotic cells to the vascular system or lymphatic vessels, and the start of the healing process (Fig. 1) (Headland and Norling 2015). These events facilitate proper return homeostasis balance (Serhan and Savill 2005). For a comprehensive review, including structural explanations of SPMs, see reviews (Park et al. 2020; Chiang and Serhan 2017; Lee 2012).

Dr. Weeks’ Comment: Here is what you need to know. These highly beneficial agents derive from the oft-maligned omega 6 fatty acids. The problem is that most omega six oils in our diet come from soy, corn, and rapeseed (canola oil). These omega 6 vegetable oils are toxic having been doused with glyphosate and becoming rancid. These oils are put into our food as preservatives. I think of them as no healthier than embalming fluid… also a preservative!


Lipoxin A4 (LXA4; 5S, 6R, 15S-trihydroxy-7E, 9E, 11Z, 13E-eicosatetraenoic acid) and lipoxin B4 (LXB4; 5S, 14R, 15S-trihydroxy-6E, 8Z, 10E, 12E-eicosatetraenoic acid) were the first lipid SPMs to be discovered (Chiang and Serhan 2017). They are produced from the conversion of omega-6 (ω-6) arachidonic acid (AA) by lipoxygenase (LOX) through unicellular and transcellular biosynthesis pathways.


Dr Weeks’ Comment: Again, we see the importance of omega 6 oils in our diet. But you need high quality, non-adulterated omega 6 oils. Organic non-GMO cold-pressed seed oils are optimal. Dr. Weeks’ patients take them in this REMEDY.

The anti-inflammatory action of mesenchymal stem cells is well known, and it is believed that these mesenchymal stem cells exhibit anti-inflammatory action through PGE2 and LXA4. These lipids mediators alleviate the SARS-CoV-2 cytokine storm, while arachidonic acid, dihomo-gamma-linolenic acid, and gamma-linolenic acid inactivate enveloped viruses (Das 2020).


Dr. Weeks’ Comment: Reminder, inflammation is a double edged sword. It can help and it can hurt. Short term, acute inflammation enhances healing while chronic low grade inflammation harms. This of the difference between acute righteous indignation, and chronic resentment. Don’t hold grudges but speak out and get concerns off your chest then move on.

“Both inflammation and resolution of inflammation are vital processes of the immune system. Therefore, a balance between the need for a sufficient immune response to clear the infection and the rapid decline of immune response to prevent host damage presents a novel opportunity for therapeutic exploitation of the SPMs.”

TAKE HOME MESSAGE: Eat organic, cold-pressed, high quality oils – coconut, olive oil, seed oils etc and eat your wild caught fish but avoid fish oil or crill oil as these constitute excessive omega 3 . Also: avoid toxic farm raise fish like Atlantic salmon and tilpia .





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