Black Cumin Seed with chemo and radiation

Dr. Weeks’ Comment: I have recommended black cumin seed for patients dealing with cancer and have educated oncologists that this seed ENHANCES the conventional standard of care treatment.

Here are some peer-reviewed scientific data suggesting it makes the therapy more effective while lessening the side-effect profile. What a great Win Win for the patient! They get the standard of care but with enhanced killing of cancer while suffering less side-effects.


In vivo radioprotective effects of Nigella sativa L oil and reduced glutathione against irradiation-induced oxidative injury and number of peripheral blood lymphocytes in rats

“The combination of thymoquinone and conventional chemotherapeutic drugs could produce greater therapeutic effect as well as reduce the toxicity of the latter. In this review, we summarize the anti-oxidant/anti-inflammatory and anticancer effects of thymoquinone with a focus on its molecular targets, and its possible role in the treatment of inflammatory diseases and cancer.”





Photochem Photobio. 2006 Nov-Dec;82(6):1691-6.

In vivo radioprotective effects of Nigella sativa L oil and reduced glutathione against irradiation-induced oxidative injury and number of peripheral blood lymphocytes in rats

Mustafa Cemek 1Hüseyin EnginarTuran KaracaPerihan Unak

Radiotherapy is one of the most common therapies for treating human cancers. Several studies have indicated that irradiation induces reactive oxygen species (ROS), which play an important role in radiation damage of the cell. It has been shown that Nigella sativa L. (NS) and reduced glutathione (GSH) have both an antiperoxidative effect on different tissues and a scavenger effect on ROS. The purpose of this study was to determine the antioxidant and radio-protective roles of NS and GSH against irradiation-induced oxidative injury in an experimental model… Also, our results suggest that NS and GSH administration prior to irradiation prevent the number of alpha-naphthyl acetate esterase peripheral blood T lymphocytes from declining. These results clearly show that NS and GSH treatment significantly antagonize the effects of radiation. Therefore, NS and GSH may be a beneficial agent in protection against ionizing radiation-related tissue injury.



For the fun of it, I asked Chat GPT AI and here is what we can learn.

Question for CHAT GPT:
“Is black cumin seed helpful during chemotherapy?”
CHAT GPT Answer:

Black cumin seed, also known as Nigella sativa, has been studied for its potential therapeutic benefits, including during chemotherapy. It contains an active compound called thymoquinone, which has demonstrated various pharmacological properties such as anti-inflammatory, antioxidant, and anti-cancer effects. Here are some ways black cumin seed may be helpful during chemotherapy:

1. Antioxidant Properties

  • Mechanism: Thymoquinone and other compounds in black cumin seed can reduce oxidative stress and protect cells from damage caused by free radicals.
  • Benefit: This may help mitigate the oxidative damage to healthy cells caused by chemotherapy, potentially reducing side effects.

2. Anti-inflammatory Effects

  • Mechanism: Black cumin seed has anti-inflammatory properties that can reduce inflammation in the body.
  • Benefit: This may help alleviate inflammatory responses associated with chemotherapy, such as mucositis and dermatitis.

3. Immune System Support

  • Mechanism: Compounds in black cumin seed can modulate the immune system, enhancing its ability to fight infections and cancer cells.
  • Benefit: Supporting the immune system may help patients better cope with the immunosuppressive effects of chemotherapy.

4. Anti-cancer Properties

  • Mechanism: Thymoquinone has shown potential in inhibiting cancer cell proliferation, inducing apoptosis (programmed cell death), and hindering metastasis in various cancer cell lines.
  • Benefit: These properties may enhance the overall effectiveness of chemotherapy by acting synergistically with anti-cancer drugs.

5. Gastroprotective Effects

  • Mechanism: Black cumin seed may protect the gastrointestinal tract from damage.
  • Benefit: This can be beneficial for patients experiencing nausea, vomiting, or other gastrointestinal side effects of chemotherapy.

Research and Clinical Evidence

  • Preclinical Studies: Many of the benefits mentioned are supported by preclinical studies (in vitro and in vivo). For example, studies have shown that thymoquinone can enhance the cytotoxic effects of certain chemotherapy drugs and reduce toxicity in animal models.
  • Human Studies: Limited clinical trials in humans suggest that black cumin seed may help improve quality of life and reduce some chemotherapy side effects. However, more robust clinical trials are needed to confirm these benefits and establish appropriate dosages and safety profiles.

Safety and Considerations

  • Interaction with Chemotherapy Drugs: While black cumin seed may offer supportive benefits, it is crucial to consider potential interactions with chemotherapy drugs. Patients should consult with their healthcare provider before adding any supplement to their regimen.
  • Dosage: The appropriate dosage of black cumin seed for patients undergoing chemotherapy is not well established. It is important to follow professional guidance to avoid potential side effects or interactions.


Black cumin seed, particularly its active component thymoquinone, shows promise in providing supportive benefits during chemotherapy, including antioxidant, anti-inflammatory, immune-modulating, and anti-cancer effects. However, patients should consult with their healthcare provider before using black cumin seed to ensure it is safe and appropriate for their specific treatment plan. More research is needed to fully understand its efficacy and safety in the context of chemotherapy.



Question for CHAT GPT:

“Is black cumin seed helpful during radiation therapy?”

CHAT GPT Answer:

Black cumin (Nigella sativa) has been studied for various potential health benefits, including its antioxidant, anti-inflammatory, and immune-modulating properties. When it comes to its use during radiation therapy, there is some preliminary research suggesting potential benefits:

  1. Radioprotective Effects: Black cumin has shown radioprotective effects in animal studies, suggesting it may help protect normal tissues from radiation-induced damage. This effect is thought to be due to its antioxidant properties, which can mitigate oxidative stress caused by radiation.
  2. Anti-inflammatory Properties: Radiation therapy can cause inflammation in the irradiated tissues. Black cumin has anti-inflammatory properties, which may help reduce inflammation and related symptoms during radiation treatment.
  3. Immune Modulation: Black cumin has been shown to have immune-modulating effects, potentially enhancing immune function. This could be beneficial during radiation therapy, as radiation can suppress the immune system.

However, it’s essential to note that much of the evidence is from animal studies or small-scale human trials, and more research is needed to establish clear guidelines and recommendations for its use during radiation therapy in humans.

Important Considerations:

  • Consultation with Healthcare Providers: Before using black cumin or any supplement during radiation therapy, it’s crucial to consult with your healthcare team. They can provide personalized advice based on your specific medical condition, treatment plan, and potential interactions.
  • Potential Interactions: Black cumin may interact with medications or affect treatment outcomes. It’s essential to inform your healthcare provider about any supplements or herbal products you are considering.
  • Quality and Dosage: Ensure you are using a high-quality product and follow recommended dosage guidelines. The efficacy and safety of supplements can vary widely based on their formulation and source.

In conclusion, while black cumin shows promise for supporting health during radiation therapy, more research is needed to fully understand its benefits and safety profile in this context. Always prioritize discussing any complementary treatments with your healthcare provider to ensure they are appropriate and safe for your individual circumstances

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