Dr. Weeks’ Comment: Hydrogen is fundamental and essential for life and vitality. Here we reveal its ability to lengthen telomeres and enhance anti-aging . But did you know it protect neurological function, such as preventing hearing loss as well as helping in post stroke situations. Here below is some new research to consider as you and I optimize our health and vitality.
HEARING LOSS
Hydrogen: a novel strategy for preventing and treating hearing loss
Abstract
Sensorineural hearing loss, often caused by irreversible damage to cochlear hair cells, is primarily mediated by oxidative stress triggered by aging, noise exposure, or ototoxic agents. Conventional treatments such as hearing aids or cochlear implants have limitations in accessibility and efficacy. Hydrogen (H2), a selective antioxidant with anti-inflammatory and anti-apoptotic properties, has demonstrated protective effects on various organ systems. This review evaluates the therapeutic potential of H2 in preventing and treating sensorineural hearing loss and aims to inform future research directions. In preclinical models of sensorineural hearing loss, H2 administration via inhalation, injection, or drinking water reduces reactive oxygen species accumulation, protects cochlear hair cells, and improves functional hearing markers (auditory brainstem response and distortion product otoacoustic emission). Clinical trials have shown that H2 inhalation improves hearing thresholds in patients with radiotherapy-induced hearing loss and idiopathic sudden sensorineural hearing loss. No serious side effects have been observed. H2‘s high diffusion capacity and selective reactive oxygen species-scavenging properties support its role as a promising therapeutic for sensorineural hearing loss. While animal data are robust and initial clinical outcomes encouraging, further large-scale studies are warranted to validate efficacy, optimize delivery methods, and establish clinical protocols.
COPD
Abstract
Objectives
Molecular hydrogen (H2) exhibits selective antioxidant, anti-inflammatory, and anti-senescence properties that may provide therapeutic benefits for chronic obstructive pulmonary disease (COPD), particularly in aging populations where oxidative stress and chronic inflammation are prominent. Given the increasing burden of aging-related COPD and the emerging biological effects of molecular hydrogen, we hypothesized that H2 therapy may exert beneficial effects by modulating oxidative stress, inflammation, and aging pathways.
Conclusions
H2 therapy shows consistent antioxidative, anti-inflammatory, and anti-senescence effects across preclinical and clinical settings, suggesting potential as an adjunctive treatment for COPD in aging populations. Further large-scale, long-term trials are warranted to confirm efficacy, optimize dosage, and clarify mechanistic pathways.
STROKE
Hydrogen gas inhalation alleviated cerebral ischemia/reperfusion injury by regulating mitophagy in SH-SY5Y cells and mice via PTEN-induced kinase 1/Parkin pathway