Black cumin seed and cancer - more science that impresses!

Dr. Weeks’ Comment: Gosh, there is so much to learn about to how to help people survive and thrive despite a cancer challenge. If only drug reps would teach we doctors about non-patentable and “centisble” ( safe and effective and cost- effective ) options like SOUL…

Last August, after drinking one packet twice a day of SOUL and after it took away 20 years of low back pain (football injury) from only 2 days of use, I went to pubmed https://www.ncbi.nlm.nih.gov/pubmed/

and searched black cumin seed (thymoquinone is a component of this seed) and various ailments. When I saw what it does for cancer and read how beneficial it is I was astonished at how I could have practiced for 25 years and not known this information! Does your oncologist know this about SOUL? I am always impressed at how much we doctors could know about being helpful if only drug reps would teach us about non-drug options!

SCAN these titles or Cut and Paste and send them to your oncologist.

Select item 245798011.

Thymoquinone, A Bioactive Component of Black Caraway Seeds, Causes G1 Phase Cell Cycle Arrest and Apoptosis in Triple-Negative Breast Cancer Cells with Mutant p53.

Sutton KM, Greenshields AL, Hoskin DW.

Nutr Cancer. 2014 Apr;66(3):408-18. doi: 10.1080/01635581.2013.878739. Epub 2014 Feb 28.

PMID:

24579801

[PubMed – in process]

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Select item 244035142.

Combinations of platinums and selected phytochemicals as a means of overcoming resistance in ovarian cancer.

Huq F, Yu JQ, Beale P, Chan C, Arzuman L, Nessa MU, Mazumder ME.

Anticancer Res. 2014 Jan;34(1):541-5.

PMID:

24403514

[PubMed – indexed for MEDLINE]

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Select item 243994653.

Thymoquinone suppression of the human hepatocellular carcinoma cell growth involves inhibition of IL-8 expression, elevated levels of TRAIL receptors, oxidative stress and apoptosis.

Ashour AE, Abd-Allah AR, Korashy HM, Attia SM, Alzahrani AZ, Saquib Q, Bakheet SA, Abdel-Hamied HE, Jamal S, Rishi AK.

Mol Cell Biochem. 2014 Apr;389(1-2):85-98. doi: 10.1007/s11010-013-1930-1. Epub 2014 Jan 8.

PMID:

24399465

[PubMed – in process]

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Select item 243479194.

Thymoquinone in the clinical treatment of cancer: Fact or fiction?

Abukhader MM.

Pharmacogn Rev. 2013 Jul;7(14):117-120. Review.

PMID:

24347919

[PubMed – as supplied by publisher]

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Select item 242960785.

Thymoquinone causes multiple effects, including cell death, on dividing plant cells.

Hassanien SE, Ramadan AM, Azeiz AZ, Mohammed RA, Hassan SM, Shokry AM, Atef A, Kamal KB, Rabah S, Sabir JS, Abuzinadah OA, El-Domyati FM, Martin GB, Bahieldin A.

C R Biol. 2013 Nov-Dec;336(11-12):546-56. doi: 10.1016/j.crvi.2013.10.007. Epub 2013 Nov 19.

PMID:

24296078

[PubMed – in process]

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Select item 242896426.

Anticancer effects of thymoquinone, caffeic acid phenethyl ester and resveratrol on A549 non-small cell lung cancer cells exposed to benzo(a)pyrene.

Ulasli SS, Celik S, Gunay E, Ozdemir M, Hazman O, Ozyurek A, Koyuncu T, Unlu M.

Asian Pac J Cancer Prev. 2013;14(10):6159-64.

PMID:

24289642

[PubMed – in process]

Free Article

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Select item 242706007.

Thymoquinone regulates gene expression levels in the estrogen metabolic and interferon pathways in MCF7 breast cancer cells.

Motaghed M, Al-Hassan FM, Hamid SS.

Int J Mol Med. 2014 Jan;33(1):8-16. doi: 10.3892/ijmm.2013.1563. Epub 2013 Nov 21.

PMID:

24270600

[PubMed – in process]

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Select item 241133168.

Thymoquinone inhibits microtubule polymerization by tubulin binding and causes mitotic arrest following apoptosis in A549 cells.

Acharya BR, Chatterjee A, Ganguli A, Bhattacharya S, Chakrabarti G.

Biochimie. 2014 Feb;97:78-91. doi: 10.1016/j.biochi.2013.09.025. Epub 2013 Oct 7.

PMID:

24113316

[PubMed – in process]

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Select item 240983779.

Thymoquinone inhibits tumor growth and induces apoptosis in a breast cancer xenograft mouse model: the role of p38 MAPK and ROS.

Woo CC, Hsu A, Kumar AP, Sethi G, Tan KH.

PLoS One. 2013 Oct 2;8(10):e75356. doi: 10.1371/journal.pone.0075356. eCollection 2013.

PMID:

24098377

[PubMed – in process]

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Select item 2404488210.

Molecular targeting of Akt by thymoquinone promotes G(1) arrest through translation inhibition of cyclin D1 and induces apoptosis in breast cancer cells.

Rajput S, Kumar BN, Dey KK, Pal I, Parekh A, Mandal M.

Life Sci. 2013 Nov 13;93(21):783-90. doi: 10.1016/j.lfs.2013.09.009. Epub 2013 Sep 15.

PMID:

24044882

[PubMed – indexed for MEDLINE]

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Select item 2403981411.

Thymoquinone inhibits autophagy and induces cathepsin-mediated, caspase-independent cell death in glioblastoma cells.

Racoma IO, Meisen WH, Wang QE, Kaur B, Wani AA.

PLoS One. 2013 Sep 9;8(9):e72882. doi: 10.1371/journal.pone.0072882. eCollection 2013.

PMID:

24039814

[PubMed – in process]

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Select item 2403651212.

Thymoquinone induces mitochondria-mediated apoptosis in acute lymphoblastic leukaemia in vitro.

Salim LZ, Mohan S, Othman R, Abdelwahab SI, Kamalidehghan B, Sheikh BY, Ibrahim MY.

Molecules. 2013 Sep 12;18(9):11219-40. doi: 10.3390/molecules180911219.

PMID:

24036512

[PubMed – indexed for MEDLINE]

Free Article

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Select item 2402052113.

Tracking NF-ÎºB activity in tumor cells during ovarian cancer progression in a syngeneic mouse model.

Wilson AJ, Barham W, Saskowski J, Tikhomirov O, Chen L, Lee HJ, Yull F, Khabele D.

J Ovarian Res. 2013 Sep 10;6(1):63. doi: 10.1186/1757-2215-6-63.

PMID:

24020521

[PubMed]

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Select item 2401284014.

Thymoquinone inhibits cell proliferation through regulation of G1/S phase cell cycle transition in N-nitrosodiethylamine-induced experimental rat hepatocellular carcinoma.

Raghunandhakumar S, Paramasivam A, Senthilraja S, Naveenkumar C, Asokkumar S, Binuclara J, Jagan S, Anandakumar P, Devaki T.

Toxicol Lett. 2013 Oct 23;223(1):60-72. doi: 10.1016/j.toxlet.2013.08.018. Epub 2013 Sep 3.

PMID:

24012840

[PubMed – indexed for MEDLINE]

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Select item 2400159415.

Thymoquinone: fifty years of success in the battle against cancer models.

Schneider-Stock R, Fakhoury IH, Zaki AM, El-Baba CO, Gali-Muhtasib HU.

Drug Discov Today. 2014 Jan;19(1):18-30. doi: 10.1016/j.drudis.2013.08.021. Epub 2013 Aug 31.

PMID:

24001594

[PubMed – in process]

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Select item 2394330616.

Pronounced transcriptional regulation of apoptotic and TNF-NF-kappa-B signaling genes during the course of thymoquinone mediated apoptosis in HeLa cells.

Sakalar C, Yuruk M, Kaya T, Aytekin M, Kuk S, Canatan H.

Mol Cell Biochem. 2013 Nov;383(1-2):243-51. doi: 10.1007/s11010-013-1772-x. Epub 2013 Aug 14.

PMID:

23943306

[PubMed – in process]

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Select item 2390012117.

Cellular responses with thymoquinone treatment in human breast cancer cell line MCF-7.

Motaghed M, Al-Hassan FM, Hamid SS.

Pharmacognosy Res. 2013 Jul;5(3):200-6. doi: 10.4103/0974-8490.112428.

PMID:

23900121

[PubMed]

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Select item 2381453018.

Prevention and Treatment of Colorectal Cancer by Natural Agents From Mother Nature.

Aggarwal B, Prasad S, Sung B, Krishnan S, Guha S.

Curr Colorectal Cancer Rep. 2013 Mar 1;9(1):37-56.

PMID:

23814530

[PubMed]

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Select item 2374436019.

Redox cycling of endogenous copper by thymoquinone leads to ROS-mediated DNA breakage and consequent cell death: putative anticancer mechanism of antioxidants.

Zubair H, Khan HY, Sohail A, Azim S, Ullah MF, Ahmad A, Sarkar FH, Hadi SM.

Cell Death Dis. 2013 Jun 6;4:e660. doi: 10.1038/cddis.2013.172.

PMID:

23744360

[PubMed – indexed for MEDLINE]

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Select item 2371114920.

Thymoquinone induces apoptosis in oral cancer cells through p38Î² inhibition.

Abdelfadil E, Cheng YH, Bau DT, Ting WJ, Chen LM, Hsu HH, Lin YM, Chen RJ, Tsai FJ, Tsai CH, Huang CY.

Am J Chin Med. 2013;41(3):683-96. doi: 10.1142/S0192415X1350047X.

PMID:

23711149

[PubMed – indexed for MEDLINE]

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Select item 2366831021.

Thymoquinone attenuates tumor growth in ApcMin mice by interference with Wnt-signaling.

Lang M, Borgmann M, Oberhuber G, Evstatiev R, Jimenez K, Dammann KW, Jambrich M, Khare V, Campregher C, Ristl R, Gasche C.

Mol Cancer. 2013 May 13;12(1):41. doi: 10.1186/1476-4598-12-41.

PMID:

23668310

[PubMed – indexed for MEDLINE]

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Select item 2361383622.

Targeted apoptotic effects of thymoquinone and tamoxifen on XIAP mediated Akt regulation in breastcancer.

Rajput S, Kumar BN, Sarkar S, Das S, Azab B, Santhekadur PK, Das SK, Emdad L, Sarkar D, Fisher PB, Mandal M.

PLoS One. 2013 Apr 17;8(4):e61342. doi: 10.1371/journal.pone.0061342. Print 2013.

PMID:

23613836

[PubMed – indexed for MEDLINE]

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Select item 2358363023.

Thymoquinone suppresses metastasis of melanoma cells by inhibition of NLRP3 inflammasome.

Ahmad I, Muneer KM, Tamimi IA, Chang ME, Ata MO, Yusuf N.

Toxicol Appl Pharmacol. 2013 Jul 1;270(1):70-6. doi: 10.1016/j.taap.2013.03.027. Epub 2013 Apr 10.

PMID:

23583630

[PubMed – indexed for MEDLINE]

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Select item 2356224224.

Synthesis, characterization and anti-tumor activity of novel thymoquinone analogs against pancreaticcancer.

Yusufi M, Banerjee S, Mohammad M, Khatal S, Venkateswara Swamy K, Khan EM, Aboukameel A, Sarkar FH, Padhye S.

Bioorg Med Chem Lett. 2013 May 15;23(10):3101-4. doi: 10.1016/j.bmcl.2013.03.003. Epub 2013 Mar 14.

PMID:

23562242

[PubMed – indexed for MEDLINE]

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Select item 2355599025.

Phosphorylated IÎºBÎ± predicts poor prognosis in activated B-cell lymphoma and its inhibition withthymoquinone induces apoptosis via ROS release.

Hussain AR, Uddin S, Ahmed M, Al-Dayel F, Bavi PP, Al-Kuraya KS.

PLoS One. 2013;8(3):e60540. doi: 10.1371/journal.pone.0060540. Epub 2013 Mar 28.

PMID:

23555990

[PubMed – indexed for MEDLINE]

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Select item 2350630226.

Maternal supplementation of diabetic mice with thymoquinone protects their offspring from abnormal obesity and diabetes by modulating their lipid profile and free radical production and restoring lymphocyte proliferation via PI3K/AKT signaling.

Badr G, Mahmoud MH, Farhat K, Waly H, Al-Abdin OZ, Rabah DM.

Lipids Health Dis. 2013 Mar 18;12:37. doi: 10.1186/1476-511X-12-37.

PMID:

23506302

[PubMed – indexed for MEDLINE]

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Select item 2327702527.

Thymoquinone induces apoptosis in malignant T-cells via generation of ROS.

Dergarabetian EM, Ghattass KI, El-Sitt SB, Al-Mismar RM, El-Baba CO, Itani WS, Melhem NM, El-Hajj HA, Bazarbachi AA, Schneider-Stock R, Gali-Muhtasib HU.

Front Biosci (Elite Ed). 2013 Jan 1;5:706-19.

PMID:

23277025

[PubMed – indexed for MEDLINE]

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Select item 2323298228.

Antitumor and anti-angiogenesis effects of thymoquinone on osteosarcoma through the NF-ÎºB pathway.

Peng L, Liu A, Shen Y, Xu HZ, Yang SZ, Ying XZ, Liao W, Liu HX, Lin ZQ, Chen QY, Cheng SW, Shen WD.

Oncol Rep. 2013 Feb;29(2):571-8. doi: 10.3892/or.2012.2165. Epub 2012 Dec 4.

PMID:

23232982

[PubMed – indexed for MEDLINE]

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Select item 2322788429.

Polo-like kinase 1 as target for cancer therapy.

WeiÃŸ L, Efferth T.

Exp Hematol Oncol. 2012 Dec 10;1(1):38. doi: 10.1186/2162-3619-1-38.

PMID:

23227884

[PubMed]

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Select item 2313183430.

Effect of thymoquinone on 1,2-dimethyl-hydrazine-induced oxidative stress during initiation and promotion of colon carcinogenesis.

Jrah-Harzallah H, Ben-Hadj-Khalifa S, Almawi WY, Maaloul A, Houas Z, Mahjoub T.

Eur J Cancer. 2013 Mar;49(5):1127-35. doi: 10.1016/j.ejca.2012.10.007. Epub 2012 Nov 3.

PMID:

23131834

[PubMed – indexed for MEDLINE]

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Select item 2308955431.

Thymoquinone efficiently inhibits the survival of EBV-infected B cells and alters EBV gene expression.

Zihlif MA, Mahmoud IS, Ghanim MT, Zreikat MS, Alrabadi N, Imraish A, Odeh F, Abbas MA, Ismail SI.

Integr Cancer Ther. 2013 May;12(3):257-63. doi: 10.1177/1534735412458827. Epub 2012 Oct 21.

PMID:

23089554

[PubMed – indexed for MEDLINE]

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Select item 2307751632.

Antineoplastic and apoptotic potential of traditional medicines thymoquinone and diosgenin in squamous cell carcinoma.

Das S, Dey KK, Dey G, Pal I, Majumder A, MaitiChoudhury S, kundu SC, Mandal M.

PLoS One. 2012;7(10):e46641. doi: 10.1371/journal.pone.0046641. Epub 2012 Oct 15.

PMID:

23077516

[PubMed – indexed for MEDLINE]

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Select item 2304362633.

Thymoquinone in liposomes: a study of loading efficiency and biological activity towards breastcancer.

Odeh F, Ismail SI, Abu-Dahab R, Mahmoud IS, Al Bawab A.

Drug Deliv. 2012 Nov;19(8):371-7. doi: 10.3109/10717544.2012.727500. Epub 2012 Oct 8.

PMID:

23043626

[PubMed – indexed for MEDLINE]

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Select item 2296007334.

NADPH quinone oxidoreductase 1 mediates breast cancer cell resistance to thymoquinone-induced apoptosis.

Sutton KM, Doucette CD, Hoskin DW.

Biochem Biophys Res Commun. 2012 Sep 28;426(3):421-6. doi: 10.1016/j.bbrc.2012.08.111. Epub 2012 Aug 30.

PMID:

22960073

[PubMed – indexed for MEDLINE]

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Select item 2293141735.

Quinones derived from plant secondary metabolites as anti-cancer agents.

Lu JJ, Bao JL, Wu GS, Xu WS, Huang MQ, Chen XP, Wang YT.

Anticancer Agents Med Chem. 2013 Mar;13(3):456-63. Review.

PMID:

22931417

[PubMed – indexed for MEDLINE]

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Select item 2278874136.

Thymoquinone as an anticancer agent: evidence from inhibition of cancer cells viability and invasion in vitro and tumor growth in vivo.

Attoub S, Sperandio O, Raza H, Arafat K, Al-Salam S, Al Sultan MA, Al Safi M, Takahashi T, Adem A.

Fundam Clin Pharmacol. 2013 Oct;27(5):557-69. doi: 10.1111/j.1472-8206.2012.01056.x. Epub 2012 Jul 13.

PMID:

22788741

[PubMed – indexed for MEDLINE]

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Select item 2273263337.

Anti-cancer effects of thymoquinone in mouse neuroblastoma (Neuro-2a) cells through caspase-3 activation with down-regulation of XIAP.

Paramasivam A, Sambantham S, Shabnam J, Raghunandhakumar S, Anandan B, Rajiv R, Vijayashree Priyadharsini J, Jayaraman G.

Toxicol Lett. 2012 Sep 3;213(2):151-9. doi: 10.1016/j.toxlet.2012.06.011. Epub 2012 Jun 23.

PMID:

22732633

[PubMed – indexed for MEDLINE]

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Select item 2257074338.

Thymoquinone, the Nigella sativa bioactive compound, prevents circulatory oxidative stress caused by 1,2-dimethylhydrazine in erythrocyte during colon postinitiation carcinogenesis.

Harzallah HJ, Grayaa R, Kharoubi W, Maaloul A, Hammami M, Mahjoub T.

Oxid Med Cell Longev. 2012;2012:854065. doi: 10.1155/2012/854065. Epub 2012 Apr 18.

PMID:

22570743

[PubMed – indexed for MEDLINE]

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Select item 2255147639.

Synthesis of double mesoporous core-shell silica spheres with tunable core porosity and their drug release and cancer cell apoptosis properties.

El-Toni AM, Khan A, Ibrahim MA, Labis JP, badr G, Al-Hoshan M, Yin S, Sato T.

J Colloid Interface Sci. 2012 Jul 15;378(1):83-92. doi: 10.1016/j.jcis.2012.04.006. Epub 2012 Apr 17.

PMID:

22551476

[PubMed – indexed for MEDLINE]

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Select item 2249089940.

[Role of NF-ÎºB in the anti-tumor effect of thymoquinone on bladder cancer].

Mu HQ, Yang S, Wang YJ, Chen YH.

Zhonghua Yi Xue Za Zhi. 2012 Feb 14;92(6):392-6. Chinese.

PMID:

22490899

[PubMed – indexed for MEDLINE]

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Select item 2247764541.

Mitigation of obesity-promoted diseases by Nigella sativa and thymoquinone.

Vanamala J, Kester AC, Heuberger AL, Reddivari L.

Plant Foods Hum Nutr. 2012 Jun;67(2):111-9. doi: 10.1007/s11130-012-0279-z. Review.

PMID:

22477645

[PubMed – indexed for MEDLINE]

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Select item 2246743042.

Characterization of thymoquinone binding to human Î±â‚-acid glycoprotein.

Lupidi G, Camaioni E, KhalifÃ© H, Avenali L, Damiani E, Tanfani F, ScirÃ¨ A.

J Pharm Sci. 2012 Jul;101(7):2564-73. doi: 10.1002/jps.23138. Epub 2012 Mar 29.

PMID:

22467430

[PubMed – indexed for MEDLINE]

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Select item 2234065143.

[Inhibitory effects of thymoquinone on human pancreatic carcinoma orthotopically implanted in nude mice].

Wang YM.

Zhonghua Yi Xue Za Zhi. 2011 Nov 29;91(44):3111-4. Chinese.

PMID:

22340651

[PubMed – indexed for MEDLINE]

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Select item 2222904744.

Impact of protein binding on the analytical detectability and anticancer activity of thymoquinone.

El-Najjar N, Ketola RA, NissilÃ¤ T, Mauriala T, Antopolsky M, JÃ¤nis J, Gali-Muhtasib H, Urtti A, Vuorela H.

J Chem Biol. 2011 Jul;4(3):97-107. doi: 10.1007/s12154-010-0052-4. Epub 2011 Jan 8.

PMID:

22229047

[PubMed]

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Select item 2220667045.

Thymoquinone inhibits growth and augments 5-fluorouracil-induced apoptosis in gastric cancer cells both in vitro and in vivo.

Lei X, Lv X, Liu M, Yang Z, Ji M, Guo X, Dong W.

Biochem Biophys Res Commun. 2012 Jan 13;417(2):864-8. doi: 10.1016/j.bbrc.2011.12.063. Epub 2011 Dec 20.

PMID:

22206670

[PubMed – indexed for MEDLINE]

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Select item 2217738146.

Thymoquinone decreases F-actin polymerization and the proliferation of human multiple myeloma cells by suppressing STAT3 phosphorylation and Bcl2/Bcl-XL expression.

Badr G, Mohany M, Abu-Tarboush F.

Lipids Health Dis. 2011 Dec 16;10:236. doi: 10.1186/1476-511X-10-236.

PMID:

22177381

[PubMed – indexed for MEDLINE]

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Select item 2217008847.

Thymoquinone reduces migration and invasion of human glioblastoma cells associated with FAK, MMP-2 and MMP-9 down-regulation.

Kolli-Bouhafs K, Boukhari A, Abusnina A, Velot E, Gies JP, Lugnier C, RondÃ© P.

Invest New Drugs. 2012 Dec;30(6):2121-31. doi: 10.1007/s10637-011-9777-3. Epub 2011 Dec 15.

PMID:

22170088

[PubMed – indexed for MEDLINE]

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Select item 2214909348.

Cancer cell signaling pathways targeted by spice-derived nutraceuticals.

Sung B, Prasad S, Yadav VR, Aggarwal BB.

Nutr Cancer. 2012;64(2):173-97. doi: 10.1080/01635581.2012.630551. Epub 2011 Dec 9. Review.

PMID:

22149093

[PubMed – indexed for MEDLINE]

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Select item 2211020149.

Synergism from combinations of cisplatin and oxaliplatin with quercetin and thymoquinone in human ovarian tumour models.

Nessa MU, Beale P, Chan C, Yu JQ, Huq F.

Anticancer Res. 2011 Nov;31(11):3789-97.

PMID:

22110201

[PubMed – indexed for MEDLINE]

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Select item 2208398250.

Anticancer activity of Nigella sativa (black seed) – a review.

Randhawa MA, Alghamdi MS.

Am J Chin Med. 2011;39(6):1075-91. Review.

PMID:

22083982

[PubMed – indexed for MEDLINE]

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Select item 2200751451.

[Anti-metastasis effect of thymoquinone on human pancreatic cancer].

Wu ZH, Chen Z, Shen Y, Huang LL, Jiang P.

Yao Xue Xue Bao. 2011 Aug;46(8):910-4. Chinese.

PMID:

22007514

[PubMed – indexed for MEDLINE]

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Select item 2200551852.

Thymoquinone: potential cure for inflammatory disorders and cancer.

Woo CC, Kumar AP, Sethi G, Tan KH.

Biochem Pharmacol. 2012 Feb 15;83(4):443-51. doi: 10.1016/j.bcp.2011.09.029. Epub 2011 Oct 10. Review.

PMID:

22005518

[PubMed – indexed for MEDLINE]

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Select item 2195020553.

Thymoquinone, the active ingredient of Nigella sativa seeds, enhances survival and activity of antigen-specific CD8-positive T cells in vitro.

Salem ML, Alenzi FQ, Attia WY.

Br J Biomed Sci. 2011;68(3):131-7.

PMID:

21950205

[PubMed – indexed for MEDLINE]

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Select item 2191264254.

Thymoquinone inhibits the CXCL12-induced chemotaxis of multiple myeloma cells and increases their susceptibility to Fas-mediated apoptosis.

Badr G, Lefevre EA, Mohany M.

PLoS One. 2011;6(9):e23741. doi: 10.1371/journal.pone.0023741. Epub 2011 Sep 1.

PMID:

21912642

[PubMed – indexed for MEDLINE]

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Select item 2190516955.

Vascular endothelial growth factor stimulates endothelial colony forming cells proliferation and tubulogenesis by inducing oscillations in intracellular Ca2+ concentration.

Dragoni S, Laforenza U, Bonetti E, Lodola F, Bottino C, Berra-Romani R, Carlo Bongio G, Cinelli MP, Guerra G, Pedrazzoli P, Rosti V, Tanzi F, Moccia F.

Stem Cells. 2011 Nov;29(11):1898-907. doi: 10.1002/stem.734.

PMID:

21905169

[PubMed – indexed for MEDLINE]

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Select item 2188191656.

Anti-neoplastic agent thymoquinone induces degradation of Î± and Î² tubulin proteins in humancancer cells without affecting their level in normal human fibroblasts.

Alhosin M, Ibrahim A, Boukhari A, Sharif T, Gies JP, Auger C, Schini-Kerth VB.

Invest New Drugs. 2012 Oct;30(5):1813-9. doi: 10.1007/s10637-011-9734-1. Epub 2011 Sep 1.

PMID:

21881916

[PubMed – indexed for MEDLINE]

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Select item 2187643757.

Antitumor promoting potential of selected phytochemicals derived from spices: a review.

Rajput S, Mandal M.

Eur J Cancer Prev. 2012 Mar;21(2):205-15. doi: 10.1097/CEJ.0b013e32834a7f0c. Review.

PMID:

21876437

[PubMed – indexed for MEDLINE]

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Select item 2183905958.

Polo-box domain inhibitor poloxin activates the spindle assembly checkpoint and inhibits tumor growth in vivo.

Yuan J, Sanhaji M, KrÃ¤mer A, Reindl W, Hofmann M, Kreis NN, Zimmer B, Berg T, Strebhardt K.

Am J Pathol. 2011 Oct;179(4):2091-9. doi: 10.1016/j.ajpath.2011.06.031. Epub 2011 Aug 10.

PMID:

21839059

[PubMed – indexed for MEDLINE]

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Select item 2167969859.

Anticancer activity of thymoquinone in breast cancer cells: possible involvement of PPAR-Î³ pathway.

Woo CC, Loo SY, Gee V, Yap CW, Sethi G, Kumar AP, Tan KH.

Biochem Pharmacol. 2011 Sep 1;82(5):464-75. doi: 10.1016/j.bcp.2011.05.030. Epub 2011 Jun 14.

PMID:

21679698

[PubMed – indexed for MEDLINE]

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Select item 2160975960.

Thymoquinone from Nigella sativa was more potent than cisplatin in eliminating of SiHa cells via apoptosis with down-regulation of Bcl-2 protein.

Ng WK, Yazan LS, Ismail M.

Toxicol In Vitro. 2011 Oct;25(7):1392-8. doi: 10.1016/j.tiv.2011.04.030. Epub 2011 May 15.

PMID:

21609759

[PubMed – indexed for MEDLINE]

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Select item 2155772761.

Radiosensitization in human breast carcinoma cells by thymoquinone: role of cell cycle and apoptosis.

Velho-Pereira R, Kumar A, Pandey BN, Jagtap AG, Mishra KP.

Cell Biol Int. 2011 Oct;35(10):1025-9. doi: 10.1042/CBI20100701.

PMID:

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Inhibitory effects of thymoquinone against 20-methylcholanthrene-induced fibrosarcoma tumorigenesis.

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Cancer Detect Prev. 2001;25(4):362-8.

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11531013

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Thymoquinone attenuates ifosfamide-induced Fanconi syndrome in rats and enhances its antitumor activity in mice.

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J Ethnopharmacol. 1999 Nov 1;67(2):135-42.

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Inhibition of benzo(a)pyrene-induced forestomach carcinogenesis in mice by thymoquinone.

Badary OA, Al-Shabanah OA, Nagi MN, Al-Rikabi AC, Elmazar MM.

Eur J Cancer Prev. 1999 Oct;8(5):435-40.

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Thymoquinone protects against doxorubicin-induced cardiotoxicity without compromising its antitumor activity.

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J Exp Clin Cancer Res. 1998 Jun;17(2):193-8.

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The in vitro anti-tumor activity of some crude and purified components of blackseed, Nigella sativa L.

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Anticancer Res. 1998 May-Jun;18(3A):1527-32.

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Thymoquinone ameliorates the nephrotoxicity induced by cisplatin in rodents and potentiates its antitumor activity.

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