Dr. Weeks’ Comment: When we use niacinamide (vitamin B3) we activate “endogenous ligands of benzodiazepine receptors of nicotinamide and inosin” so, it stands to reason that using niacinamide can help people require less dosages of prescription drugs like patented Valium and Clonazepam.
“Experiments on mice and rats were made to study the nootropic and anxiolytic properties of endogenous ligands of benzodiazepine receptors of nicotinamide and inosin
Biull Eksp Biol Med 1984 Feb;97(2):174-7.
[Nootropic and anxiolytic properties of endogenous ligands of benzodiazepine receptors and their structural analogs]
[Article in Russian]R A Akhundov, T A Voronina
- PMID: 6141825
Abstract
Experiments on mice and rats were made to study the nootropic and anxiolytic properties of endogenous ligands of benzodiazepine receptors of nicotinamide and inosin and of their new structural analogs–NMF and AZN. They were shown to have overt antihypoxic and anxiolytic effects. NMF and AZN given in 10-fold lower doses than endogenous benzodiazepine ligands appeared more active than these compounds and almost similar to diazepam as regards the activity. The data obtained point to the possibility of a purposeful search for new efficacious psychotropic and nootropic substances in the series of compounds structurally related to endogenous ligand of benzodiazepine receptors.
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- [Spectra of pharmacological activity of the endogenous ligands of the benzodiazepine receptors and their structural analogs].Akhundov RA, Voronina TA.Farmakol Toksikol. 1984 Jul-Aug;47(4):25-8.