0

Old safe and inexpensive “centsible” remedy for Alzheimer’s

Dr. Weeks’ Comment: Lithium is a fabulous mineral cheap and ready available and is neuroprotective as well. Ask your doctor about it!

Drugs Aging. 2012 Apr 14. doi: 10.2165/11599180-000000000-00000. [Epub ahead of print]

Does Lithium Prevent Alzheimer’s Disease?

Source

Laboratory of Neuroscience (LIM-27), Department and Institute of Psychiatry, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.

Abstract

Lithium salts have a well-established role in the treatment of major affective disorders. More recently, experimental and clinical studies have provided evidence that lithium may also exert neuroprotective effects. In animal and cell culture models, lithium has been shown to increase neuronal viability through a combination of mechanisms that includes the inhibition of apoptosis, regulation of autophagy, increased mitochondrial function, and synthesis of neurotrophic factors. In humans, lithium treatment has been associated with humoral and structural evidence of neuroprotection, such as increased expression of anti-apoptotic genes, inhibition of cellular oxidative stress, synthesis of brain-derived neurotrophic factor (BDNF), cortical thickening, increased grey matter density, and hippocampal enlargement. Recent studies addressing the inhibition of glycogen synthase kinase-3 beta (GSK3B) by lithium have further suggested the modification of biological cascades that pertain to the pathophysiology of Alzheimer’s disease (AD). A recent placebo-controlled clinical trial in patients with amnestic mild cognitive impairment (MCI) showed that long-term lithium treatment may actually slow the progression of cognitive and functional deficits, and also attenuate Tau hyperphosphorylation in the MCI-AD continuum. Therefore, lithium treatment may yield disease-modifying effects in AD, both by the specific modification of its pathophysiology via inhibition of overactive GSK3B, and by the unspecific provision of neurotrophic and neuroprotective support. Although the clinical evidence available so far is promising, further experimentation and replication of the evidence in large scale clinical trials is still required to assess the benefit of lithium in the treatment or prevention of cognitive decline in the elderly.

Print Friendly
Filed in: Alzheimer's, Memory

Recent Posts

© 2014 WeeksMD. All rights reserved.
WeeksMD.com is a resource provided by Dr. Bradford Weeks, M.D.

WELCOME!

The information contained on these web pages is derived from Dr. Weeks’ years of clinical experience and his review of scientific literature. However, these ideas and information are for your education and entertainment only. They are positively not intended to be a substitute for careful medical evaluation and treatment by a competent, licensed personal health care professional. Dr. Weeks and his associates do not recommend changing any current medications or adding any new therapies without personally consulting a fully qualified physician. Dr. Weeks and his staff specifically disclaim any liability arising directly or indirectly from information contained on these Web pages.

Varying and even conflicting views are held by other segments of the medical profession. The information presented on these Web pages is intended to be educational and entertaining in nature and is not intended as a basis for diagnosis or treatment. This information is current at the time of posting on the World Wide Web, and is published and distributed as a courtesy to the public.

www.seoda.info www.grafiktasarim.info www.webtasarimseo.info www.seotasarim.info www.grafikseo.info www.googledanismani.info www.devteknoloji.net www.eticaretci.org www.e-ticaretim.org www.seodanismani.biz www.farklibakis.com www.grafblog.com www.guvenliukash.info www.sagliklizayifla.ws www.eokul.ws www.simdisatinal.com www.un-mongolia.com www.un-ngls.com www.unvienna.net