Omega-3 fatty acids and bipolar disorder: a review

Prostaglandins, Leukotrienes and Essential Fatty Acids
Volume 60, Issues 5-6, May-June 1999, Pages 329-337

Omega-3 fatty acids and bipolar disorder: a review

A. L. Stolla, d, Corresponding Author Contact Information, C. A. Lockea, d, L. B. Marangellb, d and W. E. Severusc, d

a Psychopharmacology Research Laboratory, McLean Hospital, Belmont, MA 02478, USA

b Department of Psychiatry, Harvard Medical School, Boston, MA, USA

c Department of Psychiatry, Baylor College of Medicine, Houston, TX, USA

d Department of Psychiatry, Free University of Berlin, Berlin, Germany

Available online 15 February 2003.


The important role of the omega-3 fatty acids in the pathophysiology and treatment of bipolar disorder is now supported by a substantial body of indirect and direct evidence. This paper will describe the clinical and pharmacological features of bipolar disorder, review the available data regarding omega-3 fatty acids in bipolar disorder and provide recommendations for future research.



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