Progesterone for asthma

Dr. Weeks’ Comment:  Natural bio-identical progesterone is beneficial – but the patented, pharmaceutical knock off called medroxyprogesterone is not. PremPro, which featured medroxyprogesterone proved very dangerous leading to successful lawsuits against its producer Wyeth although the FDA still allows it on the  market. Natural bio-identical progesterone stimulate nerve growth, demyelination and other regenerative and highly beneficial actions in addition to the common use of helping correct the hormonal imbalances (estrogen dominance) which leads to such preventable suffering (infertility, miscarriage, PMS, fibroids and endometriosis and essential tremors). Dr. Michael Platt has clarified that one blessing of natural bio-identical progesterone is to block adrenalin. His brilliant book  Adrenalin Dominance is well worth reading and it reveals progesterone’s anti-asthma mechanism first alluded to in the 1994 British paper below.


“…The premenstrual period of the cycle is characterized by rapidly falling concentrations of ovarian hormones and supplying progesterone at this time has been shown to improve asthma control and reduce the need for systemic steroid therapy in such patients…”

“…Previous intravenous studies using animal tissues have demonstrated that both the corticosteroid and the sex steroids (17-oestradiol and progesterone) product inhibition of catecholamine o methyl transferase (COMT) and a reduction of the extra neuronal uptake of catecholamines…”


Influence of sex-steroid hormones on the regulation of lymphocyte beta 2-adrenoceptors during the menstrual cycle.


1. Up to 40% of female asthmatic subjects suffer a premenstrual deterioration in their condition which may be ameliorated by progesterone supplementation, although the mechanism responsible for this phenomenon is not understood. In vitro studies have shown that female sex-steroid hormones potentiate the bronchorelaxant effect of isoprenaline, whilst in vivo it has been shown that females exhibit greater sensitivity of systemic beta 2-adrenoceptor responses. 2. The aim of the present study was to determine whether cyclical alterations in beta 2-adrenoceptor expression, occurring under the influence of ovarian sex-steroid hormones, may offer an explanation for these findings.


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