Schizophrenia is inflammation of the Brain

Dr. Weeks’ Comment: The best blood test for risk of mental illness is an inflammatory marker: CRP.

Also it is the best test for heart disease – much more informative than the old lipid panel.


2018 Nov;269:688-691. doi: 10.1016/j.psychres.2018.08.042. Epub 2018 Aug 17.

Elevated C-reactive protein as a predictor of a random one-year clinical course in the first ten years of schizophrenia.


We investigate whether C-reactive protein (CRP) levels could predict the clinical course of patients with schizophrenia in a prospective study of 50 stable outpatients during a random 1-year period within the first 10 years of illness. Positive, negative, depressive, and cognitive symptoms were evaluated. Patients with low-grade inflammation (CRP = 3-10 mg/L; 28%) at baseline showed significant worsening of PANSS-positive and general psychopathology at 1-year follow-up compared with those with CRP ≤ 3 mg/L. Elevated CRP may be a biomarker of poor 1-year clinical course in patients with schizophrenia.

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