Humble Vitamin B1 for Parkinson’s

High Dose Thiamine Therapy for Parkinson’s Disease  


Dr. Weeks’ Comment:  The Corrective Health Institute (CHI) champions “centible” remedies, a term describing treatment options which, unlike most patented, prescription pharmaceutical drugs, are safe, effective and cost-effective. Wouldn’t it be thrilling if there were a centisble remedy for an illness like Parkinson’s disease which ravages more than 6 million people worldwide according to the Lancet 2018 [1]. Furthermore, what if that remedy could also help the many millions of people who suffer from similar neurodegenerative illnesses like Multiple sclerosis, ALS and post-stroke syndromes?


What If…

Well, if such a potent remedy did exist, and if it helped people within days and had no side-effects (being water soluble and easily cleared by healthy kidneys) and if it were inexpensive costing  $90 a year (capsules), well, everyone would be thrilled … except people whose livelihood depends upon people being sick: Big Pharma (makes of carbidopa and levodopa) and many people at various foundations claiming to help people who suffer with Parkinson’s who themselves would be out of work if a cure were discovered. (When asked to support research in HDTT, the world-famous Michael J. Fox foundation passed in 2019 and today on their website they unfortunately advise this: “At this time, the scientific evidence is insufficient to recommend thiamine for Parkinson’s.” [2] So they refused to fund research and now they discredit HDTT due to not enough research. Curious as to why they passed? Best to inquire how much Big Pharma donates to the foundation.)



In 2010, Dr. Antonio Costantini discovered the benefits of high dose thiamin therapy (HDTT) for patients with Parkinson’s disease as well as other neurodegenerative and auto-immune diseases.

Sadly, after helping more than 4000 people, the good doctor himself passed away in 2020, but happily, his treatment and copious clinical results are available at  and videos of patients’ progress may be viewed here:


An excellent presentation of his work is offered by Parkinson’s patient Daphne Bryan, Ph.D. whose book “Parkinson’s and the B1 Therapy” describes not only her improvements using HDTT but also some of the scientific rational validating this centisble remedy.


HDTT can be taken by intramuscular shot twice a week, or by sublingual tablet or by oral capsule. The IM shots work fastest followed by sublingual tablet and lastly oral HCTT can be beneficial depending upon the rate and degree of absorption in the intestines of the patient. Your doctor can give you shots starting at 50mg twice a week and increasing to 100mg twice a week. Best to take a 1 week break every 2-3 months. (Note; Injections could cause hematoma if one is taking anticoagulants). The preferred oral option is thiamine HCL (being water soluble) and not the common thiamine mononitrate. Starting dose is usually 500mg twice a day working up to 2000 to 4000mg a day. The third option is sublingual tablet which are helps under the tongue so that they dissolve and are absorbed in the mouth and don’t need to run the gauntlet of trying to be absorbed in the intestines. These sublingual tablets have been available from Superior Source:


Consistent with the principles of corrective health, which seeks to identify and correct imbalances, once the correct dose of thiamine is achieved, then it’s time to optimize the health of the patient by adding perhaps magnesium, zinc, selenium, and other minerals or vitamins which might be deficient.


What Proof is Available?

Curious minds are blessed to live in this age when so much information is available from a simple inquiry to a search engine. Do you remember the story of Aladdin and the magic lamp? All Aladdin had to do was rub the lamp and out swirled the Genie to grant his every wish. Today, we all have the opportunity which the Genie gave Aladdin; one swipe across your smart phone, and you can ask Siri or Google to answer your every inquiry (while remaining skeptical of course!) Along those lines, were you simply to google thiamine or more specifically high-dose thiamine and any illness, well you might be astonished! For starters, please find following a sample of peer-reviewed, scientific articles published in the span of 10 years by Dr. Antonio Costantini, the remarkable inventor of high-dose thiamine therapy. (HDTT). Note the use of HDTT for many illnesses in addition to simply Parkinson’s disease. HDTT does great things for energy and metabolism in the brain and nervous system.

1. High-dose thiamine and essential tremor, BMJ Case Reports, vol. 2018, pp. , 2018.

2. Long-term treatment with thiamine as possible medical therapy for Friedreich ataxia, Journal of Neurology, vol. 263, no. 11, pp. 2170–2178, 2016.

3. Can long-term thiamine treatment improve the clinical outcomes of myotonic dystrophy type 1?, Neural Regeneration Research, vol. 11, no. 9, pp. 1487–1491, 2016.

4. An open-label pilot study with high-dose thiamine in Parkinson’s disease, Neural Regeneration Research, vol. 11, no. 3, pp. 406–407, 2016

5. Thiamine and dystonia 16, BMJ Case Reports, vol. 2016, pp. , 2016.

6. Long-term treatment with high-dose thiamine in Parkinson disease: An open-label pilot study, Journal of Alternative and Complementary Medicine, vol. 21, no. 12, pp. 740–747, 2015.

7. High-dose thiamine, Alternative and Complementary Therapies, vol. 20, no. 3, pp. 161–162, 2014.

8. Thiamine and hashimoto’s thyroiditis: A report of three cases, Journal of Alternative and Complementary Medicine, vol. 20, no. 3, pp. 208–211, 2014.

9. High-dose thiamine improves fatigue after stroke: A report of three cases, Journal of Alternative and Complementary Medicine, vol. 20, no. 9, pp. 683–685, 2014.

10. High-dose thiamine as initial treatment for Parkinson’s disease, BMJ Case Reports, pp. , 2013.

11. Thiamine and fatigue in inflammatory bowel diseases: An open-label pilot study, Journal of Alternative and Complementary Medicine, vol. 19, no. 8, pp. 704–708, 2013.

12. High dose thiamine improves fatigue in multiple sclerosis, BMJ Case Reports, pp. , 2013.

13. High-dose thiamine improves the symptoms of Friedreich’s ataxia, BMJ Case Reports, pp. , 2013.

14. Thiamine and spinocerebellar ataxia type 2, BMJ Case Reports, pp. , 2013.


Other Articles re HDTT

MVMM for Parkinson


HDTT for Parkinson,on%20PD%20via%20nongenomic%20mechanisms.


HDTT for Parkinson



The Definitive Parkinson’s Questionnaire

MDS-Unified Parkinson’s Disease Rating Scale (MDS-UPDRS)


Which foods are high in thiamine? 

Most thiamine-rich foods are so because they have been supplements with this vitamin. Cereals and grains top the list but fish and pork and black beans and garlic (containing allithiamine) are naturally high in thiamine. However, to be clear: one can NOT accomplish HDTT with food alone.,Food,cereals%20and%20bread%20%5B8%5D.








Who do you know suffering with Parkinson’s? MS? ALS? Seizures? Auto-Immune illnesses, Long COVID?

Check out HDTT.

Of course, you are all welcome to call and schedule a consultation with me if you have further questions. Call 360-341-2303

Keep learning and Survive and Thrive!

Bradford S. Weeks, MD



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