Dr. Weeks’ Comment: This article abstracted below Induction of Apoptosis in Human Leukemia Cells by Grape Seed Extract is yet another example of how cancer can be addressed with non-toxic highly therapeutic natural options. Tell me: why does your oncologist not tell you about this “centisble” (safe, effective and cost- effective) remedy? Does he or she know about SOUL and that grape seed extract is in SOUL along with the powerful aids in the fight against cancer: black cumin seed and black raspberry seed?
Induction of Apoptosis in Human Leukemia Cells by Grape Seed Extract Occurs via Activation of JNK
To characterize the functional role of JNK and other apoptotic pathways in grape seed extract (GSE)-induced apoptosis in human leukemia cells by using pharmacologic and genetic approaches.
“….In summary, the present study has provided evidence that grape seed extract (GSE) induces human leukemia cell death with the activation of caspases-3, -8, and -9 as well as PARP cleavage, and that GSE-induced apoptosis is proceeded by the activation of JNK and thus up-regulation of Cip1/p21. The data presented here suggest that Cip1/p21 and JNK signaling pathway may represent attractive targets to GSE-induced apoptosis in human leukemia cells. The results of this study could have implications for the incorporation of agents such as GSE into the chemopreventive or therapeutic intervention against leukemia and possibly other hematologic malignancies…”